Retrobulbar hemodynamic parameters in men and women with open angle glaucoma

  • Ivan Marjanović Institute of Ophthalmology, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Marija Marjanović Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia
  • Ranko Gvozdenović Ophtalmology Clinic “Perfect Vision”, Subotica, Serbia
  • Dušica Risović Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Eye Clinic, University Medical Center Zvezdara, Belgrade, Serbia
Keywords: glaucoma, open-angle, men, women, intraocular pressure, ischemia, eye, diagnosis,

Abstract


Background/Aim. Several factors may have influence on systemic circulation. Additionally, peripheral circulation also demonstrates sex differences, in young women presenting significantly lower finger blood flow in comparison to men of the same age, a finding that disappears in women after menopause. The aim of this study was to compare the retrobulbar hemodynamic parameters measured by means of color Doppler imaging in women and men with open-angle glaucoma and elevated intraocular pressure. Methods. A total of 52 eyes from 52 open-angle glaucoma (OAG) patients, with elevated intraocular pressure (IOP), were included in this cross-sectional study. Peak-systolic velocity (PSV), end-diastolic velocity (EDV), and Pourcelot resistivity index (RI) were assessed in the ophtalmic artery (OA), central retinal artery (CRA), and posterior cilliary arteries (PCA). IOP was measured both with Goldmann Applanation tonometer (GAT) and with the dynamic contour tonometer (DCT), three times respectively. Ocular pulse amplitude (OPA) appeared during the DCT measurement. Results. The retrobulbar hemodynamic parameters did not show any difference between men and post-menopausal women. Conclusion. The results of our study did not find any difference between sexes in patients with open-angle glaucoma and elevated intraocular pressure.

 

Author Biography

Ivan Marjanović, Institute of Ophthalmology, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Doktor Medicine

References

Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, et al. The Ocular Hypertension Treatment Study: baseline fac–rs that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 2002; 120(6): 714−20; discussion 829−30.

Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller PJ, et al. The Ocular Hypertension Treatment Study: a randomized trial determines that –pical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 2002; 120(6): 701−13.

Heijl A, Leske CM, Bengtsson B, Hyman L, Bengtsson B, et al. Re-duction of Intraocular Pressure and Glaucoma Progression: Results from the Early Manifest Glaucoma Trial. Arch Oph-thalmol 2002; 120(10): 1268−79.

Carter CJ, Brooks DE, Doyle LD, Drance SM. Investigations in– a Vascular Etiology for Low-tension Glaucoma. Ophthalmology 1990; 97(1): 49−55.

Hayreh SS. Progress in the understanding of the vascular etiol-ogy of glaucoma. Curr Opin Ophthalmol 1994; 5(2): 26−35.

Flammer J, Orgül S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Stefánsson E. The impact of ocular blood flow in glauco-ma. Prog Retin Eye Res 2002; 21(4): 359−93.

Harris A, Kagemann L, Ehrlich R, Rospigliosi C, Moore D, Siesky B. Measuring and interpreting ocular blood flow and metabolism in glaucoma. Can J Ophthalmol 2008; 43(3): 328−36.

Werne A, Harris A, Moore D, BenZion I, Siesky B. The Circadian Variations in Systemic Blood Pressure, Ocular Perfusion Pres-sure, and Ocular Blood Flow: Risk Fac–rs for Glaucoma. Surv Ophthalmol 2008; 53(6): 559−67.

Weinreb RN, Harris A. Ocular Blood Flow in Glaucoma: The 6th Consensus Report of the World Glaucoma Association. Section II: Clinical Measurement of Ocular Blood Flow. Ams-terdam: Kugler Publications; 2009. p. 59

Galassi F, Sodi A, Ucci F, Renieri G, Pieri B, Baccini M. Ocular hemodynamics and glaucoma prognosis. Arch Ophthalmol 2003; 121(12): 1711−5.

Satilmis M, Orgül S, Doubler B, Flammer J. Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure. Am J Ophthalmol 2003; 135(5): 664−9.

Martínez A, Sánchez M. Predictive value of colour Doppler im-aging in a prospective study of visual field progression in pri-mary open-angle glaucoma. Acta Ophthalmol Scand 2005; 83(6): 716−22.

Bartelink ML, de Wit A, Wollersheim H, Theeuwes A, Thien T. Skin vascular reactivity in healthy subjects: influence of hormonal status. J Appl Physiol (1985) 1993; 74(2): 727−32.

Bollinger A, Schlumpf M. Finger blood flow in healthy subjects of different age and sex and in patients with primary Raynaud's disease. Acta Chir Scand 1976; 465(Suppl): 42−7.

Weinreb RN, Harris A. Ocular Blood Flow in Glaucoma: The 6th consensus report of the World Glaucoma Association. Section II: Clinical Measurement of Ocular Blood Flow. Ams-terdam: Kugler Publications; 2009. p. 21−2.

Lieb WE. Color Doppler ultrasonography of the eye and orbit. Curr Opin Ophthalmol 1993; 4(3): 68−75.

Butt Z, O'Brien C, McKillop G, Aspinall P, Allan P. Color Doppler imaging in untreated high- and normal-pressure open-angle glaucoma. Invest Ophthalmol Vis Sci 1997; 38(3): 690−6.

Hodapp E, Parrish R, Anderson D. Clinical Decisions in Glau-coma. St Louis, Missouri: Mosby-Year Book, Inc; 1993.

Pourcelot L. Indications de l'ultrasonographie Doppler dans l'etude des vaisseaux peripheriques. Rev Prat 1975; 25: 4671−80.

Sheskin DJ. Handbook of parametric and nonparametric statis-tical procedures. 5th ed. Boca Ra–n: Chapman & Hall /CRC; 2011.

Harris A, Harris M, Biller J, Garzozi H, Zarfty D, Ciulla TA, et al. Aging affects the retrobulbar circulation differently in women and men. Arch Ophthalmol 2000; 118(8): 1076−80.

Harris-Yitzhak M, Harris A, Ben-Refael Z, Zarfati D, Garzozi HJ, Martin BJ. Estrogen-replacement therapy: effects on retrobul-bar hemodynamics. Am J Ophthalmol 2000; 129(5): 623−8.

Centofanti M, Bonini S, Manni G, Guinetti-Neuschüler C, Bucci MG, Harris A. Do sex and hormonal status influence choroidal cir-culation. Br J Ophthalmol 2000; 84(7): 786−7.

Kavroulaki D, Gugleta K, Kochkorov A, Katamay R, Flammer J, Orgul S. Influence of gender and menopausal status on peripheral and choroidal circulation. Acta Ophthalmol 2010; 88(8): 850−3.

Published
2015/04/24
Section
Original Paper