Ultrasound accelerated thrombolysis for therapy of arterial and venous thrombosis – initial experience in the Military Medical Academy in Belgrade

Jelena Vladimir Kostić; Siniša Rusović; Zoran Trifunović; Miodrag Mihajlović; Vlastimir Marinković; Milan Šćepanović; Milan Dobrić; Slobodan Obradović

doi:10.2298/VSP150328038K

Jelena Vladimir Kostić University Clinical Center of Serbia, Clinic for Cardiology, Belgrade, Serbia
Siniša Rusović Military Medical Academy, Institute of Radiology,Belgrade, Serbia
Zoran Trifunović Military Medical Academy, Clinic for Cardiac Surgery; University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia
Miodrag Mihajlović Military Medical Academy, Institute of Radiology,Belgrade, Serbia
Vlastimir Marinković Military Medical Academy, Institute of Radiology,Belgrade, Serbia
Milan Šćepanović Military Medical Academy, Institute of Radiology,Belgrade, Serbia
Milan Dobrić University Clinical Center of Serbia, Clinic for Cardiology, Belgrade, Serbia
Slobodan Obradović Military Medical Academy, Clinic for Emergency and Internal Medicine, Belgrade, Serbia; University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia

DOI: https://doi.org/10.2298/VSP150328038K

Keywords: venous thrombosis, ultrasonic therapy, thrombolytic therapy, treatment outcome,

Abstract

Author Biographies

Siniša Rusović, Military Medical Academy, Institute of Radiology,Belgrade, Serbia

Radiology

Zoran Trifunović, Military Medical Academy, Clinic for Cardiac Surgery; University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia

Cardiac surgery

Miodrag Mihajlović, Military Medical Academy, Institute of Radiology,Belgrade, Serbia

Radiology

Vlastimir Marinković, Military Medical Academy, Institute of Radiology,Belgrade, Serbia

Radiology

Milan Šćepanović, Military Medical Academy, Institute of Radiology,Belgrade, Serbia

Radiology

Milan Dobrić, University Clinical Center of Serbia, Clinic for Cardiology, Belgrade, Serbia

Cardiology

References

Hajjar KA. The endothelium in thrombosis and hemorrhage. In: Loscalzo J, Shafer AI , editors. Thrombosis and Hemorrhage. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2003. p. 206−9.

Verstaete M. Haemostasis and thrombosis. In: Julian DG, Camm JA, Hall RJ, Poolison PA, et al, editors. Diseases of the heart. London: WB Saunders Company; 1996. p. 64−76.

Davidge ST. Prostaglandin H Synthase and Vascular Function. Circ Res 2001; 89(8): 650−60.

Smyth EM, Fitzgerald GA. Human prostacyclin receptor. Vitam Horm 2002; 65: 149−65.

Marcus AJ, Broekman MJ, Drosopoulos JH, Islam N, Pinsky DJ, Sesti C, et al. Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases. J Pharmacol Exp Ther 2003; 305(1): 9−16.

Ahmad SS, London FS, Walsh PN. The assembly of the factor X-activating complex on activated human platelets. J Thromb Haemost 2003; 1(1): 48−59.

Jurk K, Kehrel BE. Platelets: physiology and biochemistry. Semin Thromb Hemost 2005; 31(4): 381−92.

Ruggeri ZM. Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation. Best Pract Res Clin Haematol 2001; 14(2): 257−79.

Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 8(11): 1227−34.

Grunwald MR, Hofmann LV. Comparison of urokinase, altep-lase, and reteplase for catheter-directed thrombolysis of deep venous thrombosis. J Vasc Interv Radiol 2004; 15(4): 347–52.

Braaten JV, Goss RA, Francis CW. Ultrasound reversibly dis-aggregates fibrin fibers. Thromb Haemost 1997; 78(3): 1063−8.

Francis CW, Blinc A, Lee S, Cox C. Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots. Ultrasound Med Biol 1995; 21(3): 419−24.

Soltani A, Singhal R, Garcia JL, Raju NR. Absence of biological damage from prolonged exposure to intravascular ultrasound: A swine model. Ultrasonics 2007; 46(1): 60−7.

Stambo GW, Gabriel Y. Endovascular treatment of a chronically occluded limb of endograft with combination TNK pharma-cological and EKOS thrombolytic catheter system. Radiog-raphy 2011; 17(1): 81−3.

Rutherford RB, Baker JD, Ernst C, Johnston KW, Porter JM, Ahn S, et al. Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg 1997; 26(3): 517−38.

Novo S. Classification, epidemiology, risk factors, and natural history of peripheral arterial disease. Diabetes Obes Metab 2002; 4(Suppl 2): S1−6.

Mewissen MW, Seabrook GR, Meissner MH, Cynamon J, Labropoulos N, Haughton SH. Catheter-directed Thrombolysis for Lower Extremity Deep Venous Thrombosis: Report of a National Multicenter Registry. Radiology 1999; 211(1): 39−49.

Hirsh J, Guzatt G, Albers GW, Harrington R, Schȕnemann HJ. An-tithrombotic and thrombolytic therapy, ACCP Guidelines. An-tithrombotic and thrombolytic therapy. Chest 2008; 133(6 Suppl): 1105−25.

Lang EV, Kulis AM, Villani M, Barnhart W, Balano R, Cohen R. Hemolysis comparison between the OmniSonics OmniWave Endovascular System and the Possis AngioJet in a porcine model. J Vasc Interv Radiol 2008; 19(8): 1215−21.

Dwarka D, Schwartz SA, Smyth SH, O’Brien MJ. Bradyarrhyth-mias during use of the AngioJet system. J Vasc Interv Radiol 2006; 17: 1693–5.

Salazar GM, Faintuch S, Gladstone S, Lang EV. Abstract No. 373: In-Vitro Clot Removal and Particulate Analysis of the OmniWave™ Endovascular System and the Bacchus Trellis-8. J Vasc Interv Radiol 2008; 19(Suppl 2): S137.

Soltani A, Volz KR, Hansmann DR. Effect of constant versus variable ultrasound operating parameters on ultrasound-enhanced thrombolysis. Cerebrovasc Dis 2008; 26(Suppl 1): 1−20.

Parikh S, Motarjeme A, McNamara T, Raabe R, Hagspiel K, Benenati JF, et al. Ultrasound-accelerated thrombolysis for the treat-ment of deep vein thrombosis: initial clinical experience. J Vasc Interv Radiol 2008; 19(4): 521−8.

Ouriel K, Veith FJ, Sasahara AA. A Comparison of Recombi-nant Urokinase with Vascular Surgery as Initial Treatment for Acute Arterial Occlusion of the Legs. New Engl J Med 1998; 338(16): 1105−111.

EKOS in vitro data on file. Available from: www.ekoscorp.com/.../Mach4e%20PR%20final%.