Azot oksid kao prediktivni faktor inflamacije gingive kod ortodontskih bolesnika

  • Predrag Janošević University of Niš, Faculty of Medicine, Department of Orthodontics, Dental Clinic Niš, Niš, Serbia
  • Ivana Stojanović University of Niš, Faculty of Medicine, Department of Biochemistry, Niš, Serbia
  • Mirjana Janošević University of Niš, Faculty of Medicine, Department of Orthodontics, Niš, Serbia
  • Gordana Filipović University of Niš, Faculty of Medicine, Department of Orthodontics, Niš, Serbia
  • Maja Stošić University of Niš, Faculty of Medicine, Department of Orthodontics, Niš, Serbia
Ključne reči: ortodoncija, korektivna;, zapaljenje;, gingivalna sulkusna tečnost;, pljuvačka.

Sažetak


Uvod/Cilj. Ortodontska terapije fiksnim aparatima je široko rasprostranjena u terapiji malokluzija. Jedna od negativnih strana ove terapije je pojava zapaljenja gin­give tretiranih bolesnika. Cilj rada bio je procena stanja zdravlja gingive u prvih šest meseci ortodontske terapije na osnovu vrednosti kliničkih parametara krvarenja gin­give, plak indeksa, kao i koncentracije azot monoksida u pljuvačci i sulkusnoj tečnosti. Drugi cilj bio je utvrđi­vanje stepena korelacije koncentracija azot monoksida u pljuvačci i sulkusnoj tečnosti u toku prvih šest meseci terapije. Metode. Studijom je bilo obuhvaćeno 30 boles­nika Klinike za stomatologiju lečenih fiksnim orto­dont­skim aparatima (11 muškog, 19 ženskog pola), starosti 15–22 godine. Određivani su parametri, a pljuvačka i sulkusna tečnost su sakupljani pre početka, kao i tri i šest meseci posle početka terapije. Rezultati. Utvrđen je statistički značajan porast vrednosti kliničkih parame­ta­ra i koncentracije azot monoksida u toku prvih šest me­seci ortodontske terapije. Nađeni su nizak nivo sta­tis­tičke značajnosti korelacije merenih kliničkih parame­ta­ra i koncentracije azot monoksida u pljuvačci i sulkus­noj tečnosti, kao i statistički značajna korelacija koncen­tracija azot monoksida u pljuvačci i sulkusnoj tečnosti u toku prvih šest meseci terapije. Zaključak. I gingivalna sulkusna tečnost i pljuvačka su pouzdani medijumi za praćenje stanja zdravlja gingive kod ortodontskih paci­je­nata. Potrebno je sprovesti još studija koje bi rasvetlile mo­gućnost korišćenja azot monoksida kao faktora za pra­ćenje stanja zdravlja gingive kod ortodontskih bolesnika.

Reference

REFERENCES

Ireland AJ, Mcdonald F. The orthodontic patient: treatment and biomechanics. London: Oxford University Press; 2003. p. 129‒30.

Thornberg MJ, Riolo CS, Bayirli B, Riolo ML, Van Tubergen EA, Kulbersh R. Periodontal pathogen levels in adolescents before, during, and after fixed orthodontic appliance therapy. Am J Orthod Dentofacial Orthop 2009; 135(1): 95‒8.

Alexander SA. Effects of orthodontic attachments on the gin-gival health of permanent second molars. Am J Orthod Den-tofacial Orthop 1991; 100(4): 337‒40.

Matić S, Ivanović M, Nikolić P. Evaluation of a prevention pro-gramme efficiency for patients with fixed orthodontic appli-ances. Vojnosanit Pregl 2011; 68(3): 214‒9.

Corbacho de Melo MM, Cardoso MG, Faber J, Sobral A. Risk fac-tors for periodontal changes in adult patients with banded second molars during orthodontic treatment. Angle Orthod 2012; 82(2): 224‒8.

Rego RO, Oliveira CA, Santos-Pinto A, Jordan SF, Zambon JJ, Ci-relli JA, et al. Clinical and microbiological studies of children and adolescents receiving orthodontic treatment. Am J Dent 2010; 23(6): 317‒23.

Page RC. The role of inflammatory mediators in the pathogen-esis of periodontal disease. J Periodontal Res 1991; 26(3 Pt 2): 230‒42.

Dumitrescu AL. Etiology and pathogenesis of periodontal dis-ease. Heidelberg: Springer. 2010.

Zia A, Khan S, Bey A, Gupta ND, Mukhtar-Un-Nisar S. Oral biomarkers in the diagnosis and progression of periodontal diseases. Biol Med 2011; 3(2): 45‒52.

Cimasoni G. Crevicular fluid updated. Monographs in oral sci-ence. Basel: S Karger Pub; 1983.

Armitage GC. Analysis of gingival crevice fluid and risk of progression of periodontitis. Periodontology 2000 2004; 34: 109‒19.

Grenier G, Gagnon G, Grenier D. Detection of herpetic viruses in gingival crevicular fluid of patients suffering from perio-dontal diseases: Prevalence and effect of treatment. Oral Mi-crobiol Immunol 2009; 24(6): 506‒9.

Khosravi R, Tran SD, Lambert M, Loughlin JO, Kâ K, Feine JS, et al. Adiposity and gingival crevicular fluid tumour necrosis fac-tor-alpha levels in children. J Clin Periodontol 2009; 36(4): 301‒7.

Lamster IB, Novak MJ. Host mediators in gingival crevicular fluid: Implications for the pathogenesis of periodontal disease. Crit Rev Oral Biol Med 1992; 3(1‒2): 31‒60.

Matejka M, Partyka L, Ulm C, Solar P, Sinzinger H. Nitric oxide synthesis is increased in periodontal disease. J Periodontal Res 1998; 33(8): 517‒8.

Menaka KB, Ramesh A, Thomas B. A multifaceted molecule, ni-tric oxide: Its possible role in periodontitis. J Oral Health Res 2011; 2(4): 112‒7.

Skaleric U, Gaspirc B, McCartney-Francis N, Masera A, Wahl SM. Proinflammatory and antimicrobial nitric oxide in gingi-val fluid of diabetic patients with periodontal disease. Infect Immun 2006; 74(12): 7010‒3.

Wolf HE, Hassell TM. Indices. In: Wolf HE, Hassell TM, edi-tors. Color atlas of dental hygiene. Periodontology. Stuttgart, New York: Thieme; 2006. p. 67‒76.

Navarro-Gonzálvez JA, García-Benayas C, Arenas J. Semiauto-mated measurement of nitrate in biological fluids. Clin Chem 1998; 44(3): 679‒81.

Gong X, Chen W, Gong Y, Zhou L. Clinical analysis of PLI, GI and SBI in patients with fixed orthodontic appliances. Shang-hai Kou Qiang Yi Xue 2006; 15(4): 367‒9.

Shirazi M, Nilforoushan D, Alghasi H, Dehpour A. The role of nitric oxide in orthodontic tooth movement in rats. Angle Or-thod 2002; 72(3): 211‒5.

Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Mo-lecular biology of the cell. 4th ed. New York: Garland Sci-ence; 2002. p. 838-39 1304–7.

Nathan C. Nitric oxide as a secretory product of mammalian cells. Faseb J 1992; 6(12): 3051‒64.

Vandevska-Radunovic V, Kvinnsland S, Kvinnsland IH. Effect of experimental tooth movement on nerve fibres immunoreac-tive to calcitonin gene-related peptide, protein gene product 9.5, and blood vessel density and distribution in rats. Eur J Orthod 1997; 19(5): 517‒29.

D'Attillio M, di Maio F, D'Arcangela C, Filippi MR, Felaco M, Lohinai Z, et al. Gingival endothelial and inducible nitric oxide synthase levels during orthodontic treatment: A cross-sectional study. Angle Orthod 2004; 74(6): 851‒8.

Mancini L, Becherini L, Benvenuti S, Brandi ML. Bioeffects of a nitric oxide donor in a human preosteoclastic cell line. Int J Clin Pharmacol Res 1997; 17(2‒3): 93‒6.

Mentaverri R, Kamel S, Wattel A, Prouillet C, Sevenet N, Petit JP, et al. Regulation of bone resorption and osteoclast survival by nitric oxide: Possible involvement of NMDA-receptor. J Cell Biochem 2003; 88(6): 1145‒56.

Brudvik P, Rygh P. Non-clast cells start orthodontic root re-sorption in the periphery of hyalinized zones. Eur J Orthod 1993; 15(6): 467‒80.

Gaspirc B, Masera A, Skaleric U. Immunolocalization of induc-ible nitric oxide synthase in localized juvenile periodontitis pa-tients. Connect Tissue Res 2002; 43(2‒3): 413‒8.

Topcu AO, Akalin FA, Sahbazoglu KB, Yamalik N, Kilinc K, Ka-rabulut E, et al. Nitrite and nitrate levels of gingival crevicular fluid and saliva in subjects with gingivitis and chronic perio-dontitis. J Oral Maxillofac Res 2014; 5(2): e5.

Poorsattar Bejeh-Mir A, Parsian H, Akbari Khoram M, Ghasemi N, Bijani A, Khosravi-Samani M. Diagnostic Role of Salivary and GCF Nitrite, Nitrate and Nitric Oxide to Distinguish Healthy Periodontium from Gingivitis and Periodontitis. Int J Mol Cell Med 2014; 3(3): 138‒45.

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2020/12/08
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