Odnos između parametara gojaznosti i vrednosti C-reaktivnog proteina kod predgojaznih i gojaznih žena
Sažetak
Uvod/Cilj. Prekomerna telesna masa i gojaznost postali su značajan zdravstveni problem u razvijenim zemljama, a mogu biti povezani sa prisustvom hronične inflamacije niskog intenziteta u belom masnom tkivu. Cilj rada bio je da se ispitaju nivoi markera inflamacije, C-reaktivnog proteina (CRP), i njegova povezanost sa standardnim antropometrijskim parametrima kod predgojaznih i gojaznih žena. Metode. Studijom je bilo obuhvaćeno 200 zdravih žena (18–45 god) kojima su određeni standardni i alternativni antropometrijski parametari [indeks telesne mase (BMI), procenat masti (%F), obim struka (WC), odnos obima struka i kukova (WHR), odnos obima struka i visine (WHtR), kao i indeks telesne masnoće (BAI)] koji su zatim korelisani sa koncentracijama CRP u serumu. Rezultati. Prosečna vrednost nivoa CRP u serumu u celoj grupi iznosila je 5,56 ± 2,43 mg/L i utvrđena je njegova značajna pozitivna korelacija sa svim ispitivanim antropometrijskim parametrima. Uočena je statistički značajna razlika između grupa predgojaznih i gojaznih žena u svim ispitivanim antropometrijskim parametrima, kao i u pogledu koncentracije CRP. U grupi gojaznih ispitanica utvrđena je značajna povezanost između CRP i svih antropometrijskih parametara, dok u predgojaznoj grupi nije zabeležena statistička značajnost. U grupi gojaznih, svi antropometrijski pokazatelji pokazali su značajnu korelaciju sa procentom telesne masti, a kod predgojaznih žena, korelacija je bila značajna samo za telesnu masu, BMI, WC i WHtR. Zaključak. Između predgojaznih i gojaznih ispitanica postoji značajna razlika u pogledu svih pokazatelja centralne gojaznosti, kao i u pogledu koncentacije CRP u serumu. U grupi gojaznih, pokazana je značajna korelacija između sadržaja masti, izraženog kao procenat masnoće, i svih pokazatelja visceralne distribucije masti, dok u grupi predgojaznih značajna povezanost nije urađena za WHR и BAI. Naši rezultati potvrđuju da CRP može predstavljati značajan marker metaboličkog rizika kod gojaznih žena, kao i da je BMI, iako spada u tradicionalne parametre, i dalje pouzdan pokazatelj sadržaja telesne masti.
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REFERENCES
Stepien M, Stepien A, Wlazel RN, Paradowski M, Banach M, Rysz J. Obesity indices and inflammatory markers in obese non-diabetic normo- and hypertensive patients: A comparative pi-lot study. Lipids Health Dis 2014; 13: 29−38.
Stepien M, Stepien A, Wlazel RN, Paradowski M, Rizzo M, Banach M, et al. Predictors of insulin resistance in patients with obe-sity: A pilot study. Angiology 2014; 65(1): 22−30.
Pannacciulli N, Cantatore FP, Minenna A, Bellacicco M, Giorgino R, de Pergola G. C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women. Int J Obes Relat Metab Disord 2001; 25(10): 1416−20.
Jialal I, Devaraj S, Venugopal SK. C-reactive protein: Risk marker or mediator in atherothrombosis?. Hypertension 2004; 44(1): 6−11.
Koenig W, Sund M, Fröhlich M, Fischer HG, Löwel H, Döring A, et al. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augs-burg Cohort Study. Circulation 1999; 99(2): 237−42.
Ridker PM. Clinical application of C-reactive protein for car-diovascular disease detection and prevention. Circulation 2003; 107(3): 363−9.
Zeba AN, Delisle HF, Rosier C, Renier G. Association of high-sensitive C-reactive protein with cardiomatabolic risk factors and micronutrient deficiencies in adults of Ougadougou, Burk-ina Faso. Br J Nutr 2013; 109(7): 1266−75.
Sims EA. Are there persons who are obese, but metabolically healthy?. Metabolism 2001; 50(12): 1499−504.
World Healtj Organization. Obesity: Preventing and managing the global epidemic. Geneva: World Health Organization; 2000.
Durnin JV, Womersley J. Body fat assessed from total body den-sity and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 1974; 32(1): 77−97.
Bergman RN, Stefanovski D, Buchanan TA, Sumner AE, Reynolds JC, Sebring NG, et al. A better index of body adiposity. Obesity 2011; 19(5): 1083−9.
Lee CM, Huxley RR, Wildman RP, Woodward M. Indices of ab-dominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis. J Clin Epidemiol 2008; 61(7): 646−53.
Karastergiou K, Smith SR, Greenberg AS, Fried SK. Sex differences in human adipose tissues - the biology of pear shape. Biol Sex Differ 2012; 3(1): 13.
Stojanovic D, Visnjic A, Mitrovic V, Stojanovic M. Risk factors for the occurrence of cardiovascular system diseases in students. Vojnosanit Pregl 2009; 66(6): 453−8. (Serbian)
Balistreri CR, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Me-diators Inflamm 2010; 2010: 802078.
Rexrode KM, Pradahan A, Manson JE, Buring JE, Ridker PM. Re-lationship of total and abdominal adiposity with CRP and IL-6 in women. Ann Epidemiol 2003; 13: 674−82.
Leal Vde O, Mafra D. Adipokines in obesity. Clin Chim Acta 2013; 419: 87−94.
Coelho M, Oliveira T, Fernandes R. Biochemistry of adipose tis-sue: an endocrine organ. Arch Med Sci 2013; 9(2): 191−200.
Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflamma-tion and metabolic disease. Nat Rev Immunol 2011; 11(2): 85−97.
Fuentes E, Fuentes F, Vilahur G, Badimon L, Palomo I. Mecha-nisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome. Mediators In-flamm 2013; 2013: 136584.
Rodriguez-Hernandez H, Simental-Mendia LE, Rodriguez-Ramirez G, Reyes-Romero MA. Obesity and imflammation: Epidemiology, risk factors, and markers of inflammation. Int J Endocrinol 2013; 2013: 678159.
Patel PS, Buras ED, Balasubramanyam A. The role of immune system in obesity and insulin resistance. J Obes 2013; 2013: 616193.
Han JM, Levings MK. Immune regulation in obesity-associated adipose inflammation. J Immunol 2013; 191(2): 527−32.
Bluher M. Adipose tissue dysfunction contributes to obesity re-lated metabolic diseases. Best Prac Res Clin Endocrinol Metab 2013; 27(2): 163−77.
Berg AH, Scherer PE. Adipose tissue, inflammation, and cardio-vascular disease. Circ Res 2005; 96(9): 939−49.
Visser M, Bouter LM, McQuillan GM, Were MH, Harris TB. Low-grade systemic inflammation in overweight children. Pediatrics 2001; 107(1): E13.
Forsythe LK, Livingstone MB, Barnes MS, Horigan G, Wallace JM. C-reactive protein and body composition in a representative sample of young adults. Proceed Nutr Soc 2009; 67(OCE7): E267.