Neobičan slučaj Marchiafava-Bignami bolesti koja se manifestovala kao aksijalna hipotonija

  • Svetlana D. Miletić Drakulić University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
  • Jasna Jevdjić University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
  • Dejan Aleksić University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
  • Gordana Tončev University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
DOI: https://doi.org/10.2298/VSP160523099M
Ključne reči: alkoholizam;, corpus callosum;, dijagnoza;, marchiafava-bignami bolest;, tomografija, kompjuterizovana, rendgenska.

Sažetak


Uvod: Marchiafava-Bignami bolest je veoma retka i najčešće je udružena sa hroničnom konzumacijom alkohola koja dovodi do progresive demijelinizacije i nekroze korpusa kalozuma. Prikaz bolesnika. Prikazana je žena stara 35 godina sa istorijom konzumiranja alkohola i pothranjenosti. Neurološkim pregledom nađena je aksijalna hipotonija, dizartričan govor i gubitak motorne koordinacije. Primenom multislajsne kompjuterizovane tomografije mozga otkrivena je hipodenzna lezija korpus kalozuma. Na osnovu anamneze, kliničkog nalaza i neuroradiološke eksploracije postavljena je dijagnoza akutne forme Marchiava-Bignami bolesti. Definitivna dijagnoza je potvrđena autopsijom. Zaključak. Marchiafava-Bignami bolesti je urgentno medicinsko stanje i njeno rano prepoznavanje i rano agresivno lečenje su ključni za povoljan ishod. Prema našem znanju, ovo je prvi slučaj Marchiava-Bignami oboljenja koje se kod bolesnika prezentovalo kao aksijalna hipotonija.

Biografije autora

Svetlana D. Miletić Drakulić, University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia

Profesor

Neurologija

Jasna Jevdjić, University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia

Anesteziologija

Profesor

Dejan Aleksić, University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia

doktor medicine

specijalizant neurologije

Gordana Tončev, University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia

Neurologija

Profesor

Reference

Carrilho PE, Santos MB, Piasecki L, Jorge AC. Marchiafava-Bignami disease: A rare entity with a poor outcome. Rev Bras Ter Intensiva 2013; 25(1): 68–72. (English, Portuguese)

Hillbom M, Saloheimo P, Fujioka S, Wszolek ZK, Juvela S, Leone MA. Diagnosis and management of Marchiafava-Bignami dis-ease: a review of CT/MRI confirmed cases. J Neurol Neuro-surg Psychiatr 2014; 85(2): 168–73.

Garcia-Santibanez R. Marchiafava-Bignami disease presenting as acute dysarthria and ataxia. Alcohol Alcohol 2015; 50(2): 256–7.

Kumar KS, Challam RJ, Singh WJ. Marchiafava - Bignami Dis-ease: A Case Report. JCDR 2014; 8(8): RD01–RD02.

Murthy KP. Magnetic resonance imaging in Marchiafava-Bignami syndrome: a cornerstone in diagnosis and prognosis. Case Rep Radiol. 2014; 2014: 609708.

Wagh SJ, Dabhi AS, Thorat PB, Vasava JF, Modia JP, Shah MJ. Marchiafava-Bignami disease: a rare presentation of chronic alcoholism. J Indian Acad Clin Med 2012; 13(4): 59–61.

Tung CS, Wu SL, Tsou JC, Hsu SP, Kuo HC, Tsui HW. Marchi-afava-Bignami disease with widespread lesions and complete recovery. AJNR Am J Neuroradiol 2010; 31(8): 1506–7.

Koeppen AH, Barron KD. Marchiafava-Bignami disease. Neu-rology 1978; 28(3): 290–4.

Dujmovic I, Nikolic I, Gavric-Kezic M, Dackovic J, Mesaros S, Drulovic J. Teaching NeuroImages: reversible widespread brain MRI lesions in Marchiafava-Bignami disease. Neurology 2015; 84(11): e81–2.

Objavljeno
2021/05/20
Broj časopisa
Vol. 76 Br. 6 (2019): Vojnosanit pregl
Rubrika
Prikaz bolesnika