Karakteristike mukoze želuca i duodenuma kod bolesnika sa primarnim bilijarnim holangitisom

  • Dragan Popović Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Belgrade, Serbia
  • Sanja Zgradić Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Belgrade, Serbia
  • Sanja Dragašević Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Belgrade, Serbia
  • Simon Zec University of Belgrade, Faculty of Medicine, Belgrade, Serbia
  • Marijan Micev University of Belgrade, Faculty of Medicine, Belgrade, Serbia
  • Tamara Naumović University of Belgrade, Faculty of Medicine, Belgrade, Serbia
  • Tomica Milosavljević Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Belgrade, Serbia
  • Tamara Milovanović Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Belgrade, Serbia
DOI: https://doi.org/10.2298/VSP161123141P
Ključne reči: jetra, bilijarna ciroza;, gastritis, atrofijski;, gluten;, celijakija;, komorbiditet;, histologija;, helicobacter pylori.

Sažetak


Uvod/Cilj. Primarni bilijarni holangitis (PBC) je imunski posredovana hronična holestatska bolest jetre sa sporom progresijom. Cilj našeg istraživanja bio je da se utvrdi korelacija između PBC, atrofičnog gastritisa (AG) i gluten-senzitivne enteropatije (GSE), da se identifikuju makro­skopske i histopatološke promene mukoze želuca i duodenuma kod PBC i analizira učestalost ovih promena u poređenju sa kontrolnom grupom. Metode. U studiju je bilo uključeno 50 bolesnika sa PBC i 46 kontrolnih bolesnika sa dispeptičnim tegobama, bez bolesti jetre. Svi ispitanici su bili podvrgnuti ezofagogastroduodenoskopiji. Makroskopski i histopatološki nalaz i uzorak mukoze želuca i duodenuma su snimljeni i analizirani. Rezultati. Nije registrovana statističk iznačajna povezanost između PBC i AG, između PBC i Helicobacter pylori infekcije. Uočena je visokostatistički značajna razlika u učestalosti Helicobacter pylori infekcije i postojanja GSE kod bolesnika u kontrolnoj grupi u odnosu na one sa PBC. Zaključak. Bolesnici sa PBC imaju manji rizik za Helicobacter pylori infekciju i AG. Testiranje za GSE kod PBC bolesnika može biti korisno, s obzirom na veću učestalost GSE među ovim bolesnicima. GSE predstavlja faktor rizika od prisustva PBC i bolesnici sa GSE imaju skoro četiri puta veću predispoziciju za PBC.

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2021/05/20
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Vol. 76 Br. 6 (2019): Vojnosanit pregl
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Originalni članak