Efikasnost transrektalne ultrasonografije (TRUS) u preoperativnoj proceni stadijuma rektalnog karcinoma
Sažetak
Apstrakt
Uvod/Cilj: Ishod lečenja rektalnog karcinoma zavisi od stadijuma u kome je otkriven. Postoji više klasifikacionih sistema koji se primenjuju u cilju određivanja proširenosti karcinoma. Cilj ovog istraživanja bio je upoređivanje efikasnosti transrektalne ultrasonografije (TRUS) u preoperativnoj lokalnoj proceni stadijuma rektalnog karcinoma uz pomoć različitih endosonografskih sondi (180° vs. 360°), kao i uticaj iskustva endoksopiste na izvođenje TRUS. Metode. Istraživanje je sprovedeno na 127 bolesnika tokom perioda od šest godina. Pregledan je 71 bolesnik uz pomoć 180° endosonografske sonde (grupa A) i 56 bolesnika uz pomoć 360° rotirajuće sonde (grupa B). Svi nalazi su komparirani sa patohistološkim izveštajima. Rezultati. TRUS je pokazao ukupnu dijagnostičku senzitivnost od 91,3% za tumor (T) kategoriju (k = 0.866, SE (k) = 0.038, p < 0.0001), i 71,7% za nodus (N) kategoriju (κ = 0.374, SE (k) = 0.082, p < 0.0001). U grupi A, TRUS je pokazao senzitivnost od 88,7% za T kategoriju (κ = 0.805, SE (k) = 0.063, p < 0.0001), i 70,4% za N kategoriju (κ = 0.376, SE (k) = 0.101, p < 0.0001). U grupi B, TRUS je pokazao senzitivnost od 94.6% za T kategoriju (κ = 0.920, SE (k) = 0.044, p < 0.0001), i 73,2% za N kategoriju (κ = 0.379, SE (k) = 0.131, p = 0.004). Iskustvo endoskopiste u izvođenju TRUS nije imalo značajniji uticaj na preoperativnu procenu stadijuma rektalnog karcinoma. Zaključak. Efikasnost i tačnost TRUS u preoperativnoj lokalnoj proceni stadijuma rektalnog karcinoma je visoka. Naši rezultati ukazuju da ne postoji značajna razlika u dijagnostici rektalnog karcinoma uz pomoć različitih endosonografskih sondi (180° vs. 360°). Takođe, pokazano je da iskustvo endoskopiste u izvođenju TRUS ne utiče značano na procenu stadijuma rektalnog karcinoma.
Reference
REFERENCES
Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Es-timates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007; 18(3): 581–92.
Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61(4): 212–36.
Hildebrandt U, Feifel G. Preoperative staging of rectal cancer by intrarectal ultrasound. Dis Colon Rectum 1985; 28(1): 42–6.
Valentini V, Beets-Tan R, Borras JM, Krivokapić Z, Leer JW, Påhlman L, et al. Evidence and research in rectal cancer. Ra-diother Oncol 2008; 87(3): 449–74.
McKeown E, Nelson DW, Johnson EK, Maykel JA, Stojadinovic A, Nissan A, et al. Current approaches and challenges for mo-nitoring treatment response in colon and rectal cancer. J Can-cer 2014; 5(1): 31–43.
Wild JJ, Reid JM. Diagnostic use of ultrasound. Brit Phys Med 1956; 11: 248–57.
Harewood GC. Assessment of publication bias in the reporting of EUS performance in staging rectal cancer. Am J Gastro-enterol 2005; 100(4): 808–16.
Herzog U, von Flüe M, Tondelli P, Schuppisser JP. How accurate is endorectal ultrasound in the preoperative staging of rectal cancer? Dis Colon Rectum 1993; 36(2): 127–34.
Xu D, Ju HX, Qian CW, Jiang F. The value of TRUS in the staging of rectal carcinoma before and after radiotherapy and comparison with the staging postoperative pathology. Clin Ra-diol 2014; 69(5): 481–4.
Siddiqui AA, Fayiga Y, Huerta S. The role of endoscopic ultra-sound in the evaluation of rectal cancer. Int Semin Surg Oncol 2006; 3: 36.
Colaiácovo R, Assef MS, Ganc RL, Carbonari AP, Silva FA, Bin FC, et al. Rectal cancer staging: Correlation between the eva-luation with radial echoendoscope and rigid linear probe. En-dosc Ultrasound 2014; 3(3): 161–6.
Hildebrandt U, Feifel G, Schwarz HP, Scherr O. Endorectal ultra-sound: instrumentation and clinical aspects. Int J Colorectal Dis 1986; 1(4): 203–7.
Muthusamy VR, Chang KJ. Optimal methods for staging rectal cancer. Clin Cancer Res 2007; 13(22 Pt 2): 6877s-84s.
Schaffzin DM, Wong WD. Endorectal ultrasound in the preo-perative evaluation of rectal cancer. Clin Colorectal Cancer 2004; 4(2): 124–32.
Bipat S, Glas AS, Slors FJ, Zwinderman AH, Bossuyt PM, Stoker J. Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging--a meta-analysis. Radiology 2004; 232(3): 773–83.
Solomon MJ, McLeod RS. Endoluminal transrectal ultraso¬no-graphy: accuracy, reliability, and validity. Dis Colon Rectum 1993; 36: 200–5.
Garcia-Aguilar J, Pollack J, Lee SH, Hernandez de Anda E, Mellgren A, Wong WD, et al. Accuracy of endorectal ultrasonography in preoperative staging of rectal tumors. Dis Colon Rectum 2002; 45(1): 10–5.
Stepansky A, Halevy A, Ziv Y. Preoperative staging using trans-rectal ultrasound in high and low rectal cancer. Isr Med Assoc J 2010; 12(5): 270–2.
Kim MJ. Transrectal ultrasonography of anorectal diseases: advantages and disadvantages. Ultrasonography 2015; 34(1): 19–31.
Orrom WJ, Wong WD, Rothenberger DA, Jensen LL, Goldberg SM. Endorectal ultrasound in the preoperative staging of rectal tumors. A learning experience. Dis Colon Rectum 1990; 33(8): 654–9.
Lahaye MJ, Engelen SM, Nelemans PJ, Beets GL, van de Velde CJ, van Engelshoven JM, et al. Imaging for predicting the risk factors--the circumferential resection margin and nodal disease--of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR 2005; 26(4): 259–68.
Dworák O. Number and size of lymph nodes and node metas-tases in rectal carcinomas. Surg Endosc 1989; 3(2): 96–9.
Rifkin MD, Ehrlich SM, Marks G. Staging of rectal carcinoma: prospective comparison of endorectal US and CT. Radiology 1989; 170(2): 319–22.
Guinet C, Buy JN, Ghossain MA, Sézeur A, Mallet A, Bigot JM, et al. Comparison of magnetic resonance imaging and computed tomography in the preoperative staging of rectal cancer. Arch Surg 1990; 125(3): 385–8.
Al-Sukhni E, Milot L, Fruitman M, Beyene J, Victor JC, Schmocker S, et al. Diagnostic accuracy of MRI for assessment of T cate-gory, lymph node metastases, and circumferential resection margin involvement in patients with rectal cancer: a systematic review and meta-analysis. Ann Surg Oncol 2012; 19(7): 2212–23.