Udruženost vaskularnih i inflamatornih markera metaboličkih poremećaja kod žena sa sindromom policističnih jajnika

  • Aleksandra Atanasova Boshku University Clinic of Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia
  • Daniela Ivanova Panova University Clinic of Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia
  • Beti Zafirova Ivanovska University Clinic of Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia
DOI: https://doi.org/10.2298/VSP170504158B
Ključne reči: jajnik, policistični, sindrom, kardiovaskularne bolesti, faktori rizika, homocistein, c-reaktivni protein

Sažetak


Apstrakt

 

Uvod/Cilj. Prevalencija metaboličkih poremećaja, gojazno­sti i insulinske rezistencije kod žena sa sindromom policističnih jajnika (PCOS) prisutna je u ranim fazama života i postavlja ovu grupu u rizik za rani razvoj kardiova­skularnih bolesti. Hiperhomocisteinemija i povecana aktiv­nost C-re­aktivnog protein (CRP) imaju uticaj na promociju ateroskleroze. Cilj ove studije je bio da se proceni da li su vrednosti visoko senzitivnog (hs-CRP) i homocisteina (Hcy) povišene kod PCOS i da se razjasne njihove moguće veze sa go­jaz­nošću, insulinskom rezistencijom i metaboličkim pro­mena­ma. Metode. Serumski nivoi hs-CRP i plazma nivoi Hcy su bili analizirani kod 73 žene sa PCOS i 43 zdrave žene, zajedno sa kliničkim, antropometrijskim i hormon­skim parametrima. Rezultati. Srednje vrednosti indeksa te­lesne mase (BMI), obima struka, odnosa kukova i struka kao i koncentracija luteinizirajuceg hormona, testosterona, an­droste­nediona, indeksa slobodnog androgena, insulina na gladno, homeostatskog modela za procenu insulinske rezi­stencije (HOMA-IR), i Hcy su bili značajno povećane kod žena sa PCOS u poređenju sa zdravim ženama istih godina. Ustanovljena je pozitivna korelacija između hs-CRP i BMI, holesterola, insulina, triglicerida (p < 0,001) i značajna nega­tivna korelacija sa luteinirirajućim hormonom (LH), vezujućim globulinom polnih hormona (SHGB), HOMA-IR, HDL-C (p < 0,001). Koncentracija Hcy imala je značajnu negativnu korelaciju sa HDL-C (p < 0,05). Zaključak. Istraživanjem je ustanovljena povećana srednja koncentracija Hcy i hs-CRP kod žena sa PCOS. Naši rezul­tati ukazuju na opravdanost upotrebe ovih biomarkera u proceni potencijalnog rizika za kardiovaskularne bolesti i rane prognoze i implikacija lečenja.

Reference

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Objavljeno
2021/02/24
Broj časopisa
Vol. 76 Br. 7 (2019): Vojnosanit Pregled
Rubrika
Originalni članak