Imunohistohemijska ekspresija androgenih receptora kod karcinoma prostate i benigne hiperplazije prostate

  • Sandra Trivunić Dajko University of Novi Sad, Faculty of Medicine, Department of Pathology
  • Jovo Bogdanović University of Novi Sad, Faculty of Medicine, Department of surgery
  • Aleksandra Fejsa Levakov University of Novi Sad Department of Histology and Embriology; Clinical Centre of Vojvodina, Centre for Pathology and Histology
  • Mirjana Živojinov University of Novi Sad, Faculty of Medicine, Department of Pathology
  • Matilda Djolai University of Novi Sad, Faculty of Medicine, Department of Histology and Embriology, Novi Sad, Serbia; Clinical Centre of Vojvodina, Centre for Pathology and Histology
DOI: https://doi.org/10.2298/VSP170629083T
Ključne reči: prostata, neoplazme;, receptori, androidni;, prostata, hiperplazija;, imunohistohemija

Sažetak


Uvod/Cilj. Karcinom prostate (PCa), kao i njegov isho­dišni organ se nalaze pod uticajem hormona, što je iskorišćeno u terapijske svrhe. Androgeni preko androgenih receptora (AR) utiču na ćelijski rast i funkciju, proliferaciju, diferen­ci­jaciju, apoptozu, lipidni metabolizam i sekretornu aktivnost prostate, ali i na razvoj i progresiju PCa. Antiandrogena terapija se sprovodi kod bolesnika sa metastaskim PCa, upravo sa ciljem da blokira dejstvo androgena. Imuno­histo­hemijskom analizom AR u tkivu prostate sa karcinomom, možemo da pretpostavimo kako će tumor reagovati na datu antiandrogenu terapiju, bilo da se radi o androgen pozi­tiv­nim ili androgen negativnim, rezistentnim tumorima. Sazna­nja o zastupljenosti AR u tkivu tumora mogla bi poslužiti kao prognostički indikator u patohistološkoj analizi. Cilj rada je bio evaluacija ekspresije AR kod bolesnika sa benignom hiperplazijom (BHP) i kod bolesnika sa PCa, pre sprovedene terapije. Metode. Imunohistohemijska analiza je sprovedena uz upotrebu anti-human AR monoclonal antibody AR441 (DAKO), uz semikvantitativnu procenu prisustva i inteziteta AR kod 195 bolesnika, 165 sa BHP i 30 sa PCa. Materijal je dobijen iglenom biopsijom ili transuretralnom resekcijom prostate (TURP). Rezultati. Sve sekretorne ćelije kod bolesnika sa BHP su bile intezivno androgen pozitivne, dok su kod bolesnika sa PCa, mahom bile umereno do izrazito pozitivne, ali sa fokusima negativnosti. Uočena je negativna korelacija AR sa Gleason skorom i International Society of Urologic Pathology (ISUP) gradus grupom PCa, koja nije bila statistički značajna. Zaključak. Rezultati studije su pokazali da je PCa, pre sprovedene terapije, andro­gen zavisan sa visokim stepenom ekspresije AR.

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Objavljeno
2021/05/21
Broj časopisa
Vol. 77 Br. 4 (2020): Vojnosanit Pregl
Rubrika
Kratko saopštenje