Korelacija fokalne neuroendokrine diferencijacije u karcinomu prostate sa parametrima od prediktivnog značaja

Milica Lj Mijovic; Aleksandar  Ćorac; Sonja  Smiljić; Sladjana  Savić; Predrag  Mandić; Leonida  Vitković; Snežana  Leštarević; Snežana  Janićijević Hudomal

doi:10.2298/VSP170930019M

Milica Lj Mijovic University of Priština/Kosovska Mitrovica, Faculty of Medicine, Institute of Pathology, Kosovska Mitrovica, Serbia
Aleksandar Ćorac University of Priština/Kosovska Mitrovica, Faculty of Medicine, Department of Preventive Medicine, Kosovska Mitrovica, Serbia
Sonja Smiljić University of Priština/Kosovska Mitrovica, Faculty of Medicine, Institute of Physiology, Kosovska Mitrovica, Serbia
Sladjana Savić University of Priština/Kosovska Mitrovica, Faculty of Medicine, Institute of Histology, Kosovska Mitrovica, Serbia
Predrag Mandić University of Priština/Kosovska Mitrovica, Faculty of Medicine, Institute of Anatomy, Kosovska Mitrovica, Serbia
Leonida Vitković University of Priština/Kosovska Mitrovica, Faculty of Medicine, Institute of Histology, Kosovska Mitrovica, Serbia
Snežana Leštarević University of Priština/Kosovska Mitrovica, Faculty of Medicine, Institute of Histology, Kosovska Mitrovica, Serbia
Snežana Janićijević Hudomal University of Priština/Kosovska Mitrovica, Faculty of Medicine, Institute of Pharmacology, Kosovska Mitrovica, Serbia

DOI: https://doi.org/10.2298/VSP170930019M

Ključne reči: prostatic neoplasms, neuroendocrinology, prostate-specific antigen, risk factors, neoplasm staging, prognosis

Sažetak

Abstract

Background/Aim. Neuroendocrine (NE) cells are one of the epithelial populations in the prostate. It is well-known that the focal neuroendocrine differentiation (FNED) in prostate cancer (PC) is an aggressive subtype that most commonly evolves from preexisting PC which does not respond to hormone therapy (androgen independed PC). The incidence and clinical importance of FNED in PC is not clearly understood because of conflicting results in the studies, and evaluation of FNED is not routinely performed in clinical practice. The aim of the present study is to determine the importance of FNED presence in the examined prostate changes with special reference to the relationship of FNED degree in PC with some parameters of predictive value [Gleason score, preoperative serum total prostata specific antigen (PSA) value, tumor volume and tumor stage]. Methods. The study included the biopsy material from 100 untreated consecutive prostate pathological changes: 70 PC, 20 prostatic intraepithelial neoplasia (PIN) and 10 benign prostatic hyperplasia (BPH). The patients with PIN and BPH were the control groups. A block containing part of the main bulk of pathological change was chosen as representative based on hematoxylin-eosin appearance, and a section of this block was immunohistochemically stained for the tissue PSA (to mark prostatic secretory cells) and chromogranin A, serotonin and synaptophysin (to mark NE cells). Results. We found a very pronounced degree of FNED differentiation in 16 (22.9%) PC. Ten (62.5%) of them had Gleason score ≥ 7, the average serum PSA level was 32.62 ± 30.80 ng/mL, average tumor volume was 43.18 ± 31.45 mL and 6 (37.5%) of this PC were detected in D clinical stage with distant hematogenous metastases. The FNED is negatively correlated with the serum PSA level, Gleason score and clinical stage positively correlated with the tumor volume, but without statistically significant differences. Conclusion. The FNED has no significant role in the prognosis of PC.

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Correlation of focal neuroendocrine differentiation in prostate cancer with the parameters of predictive value

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