Correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation

Bojana M Dačić Krnjaja; Jelena Potić; Danijela Raonić; Milenko Stojković

doi:10.2298/VSP171109185D

Bojana M Dačić Krnjaja Univerzitet u Beogradu, Medicinski fakultetKlinika za očne bolesti, Kliniči centar Srbije
Jelena Potić Clinic for Eye Diseases, Clinical Center of Serbia, Belgrade, Serbia
Danijela Raonić Clinical Centre of Montenegro, ‡Clinic for Eye Disease, Podgorica, Montenegro
Milenko Stojković University of Belgrade, Faculty of Medicine, Belgrade, SerbiaClinic for Eye Diseases, Clinical Center of Serbia, Belgrade, Serbia

DOI: https://doi.org/10.2298/VSP171109185D

Ključne reči: oko, suvo, sindromi, konjunktiva, citologija, osetljivost i specifičnost, dijagnostički testovi, rutinski, dijagnoza, diferencijalna

Sažetak

Apstrakt

Uvod/Cilj. Nova unapređena definicija bolesti suvog oka ističe hiperosmolarnost i upalu sa inicijalnom nestabilnošću suznog omotača kao najčešće etiološke faktore. Cilj rada bio je da se ispita korelacija između nekih često korišćenih kliničkih testova za suvo oko i citološkog nalaza epitela konjuktive dobijenog skrejpingom pri utvrđivanju inflamacije suvog oka. Metode. Od ispitanih 100 bolesnika, dijagnozu suvog oka smo postavili kod 80. Učinjeno je merenje sekrecije suza bez anestezije u 5 minuta Schirmer trakom (Schirmer I), vreme prekida suznog filma obojenog fluoresceinom (Fluorescein Tear Break Up Time – FTBUT), bojenje površine oka vitalnom bojom Rose Bengal (RB). Ispitano je prisustvo nabora konjunktive paralelnih ivica donjeg kapka (Lid-Parallel Conjunctival Folds – LIPCOF), izmerena visina meniskusa suza (Tear Meniscus Height – TMH) i urađen test grananja suze (Tear Ferning – TF). Rezultati. FTBUT je pokazao najvišu senzitivnost (93,6%). Najvišu specifičnost je pokazao RB test (93,2%), ali je visoka specifičnost utvrđena i kod Shirmer I, TF i FTBUT testa (89,8%, 84,5%, 78,0%). Najbolju korelaciju sa citološkim nalazom konjunktivnog skrejpinga imali su RB i FTBUT (r = 0,707, p < 0,001; r = -0.507, p < 0,001). Zaključak. FTBUT iako često korišćen u kombinaciji sa drugim testovima, samostalno je pokazao značajno visoku senzitivnost i specifičnost, kao i dobru korelaciji sa inflamacijom u sklopu bolesti suvog oka citološki detektovanoj skrejpingom konjunktive.

Reference

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