Porodična istorija bolesti i rizik od nastanka glioma: rezultati studije slučaj-kontrola

  • Ana Azanjac Arsić University of Kragujevac, Faculty of Medical Sciences, Department of Neurology
  • Gordana University of Kragujevac, Faculty of Medical Sciences, Department of Neurology
  • Svetlana University of Kragujevac, Faculty of Medical Sciences, Department of Neurology
  • Katarina Vesic University of Kragujevac, Faculty of Medical Sciences, Department of Neurology
  • Dejan Aleksic University of Kragujevac, Faculty of Medical Sciences, Department of Neurology
  • Gorica Maric University of Belgrade, Faculty of Medicine, Institute of Epidemiology
  • Tatjana Pekmezovic University of Belgrade, Faculty of Medicine, Institute of Epidemiology
DOI: https://doi.org/10.2298/VSP191127001A
Ključne reči: glioma, porodična istorija bolesti;, istorija bolesti, uzimanje;, epidemiologija;, neoplazme

Sažetak


Uvod/Cilj. Maligni gliomi predstavljaju heterogenu grupu tumora koji se javljaju većinom kod starijih muškaraca. Cilj ove studije bio je da ispita vezu između porodične istorije bolesti i rizika od nastanka glioma. Metode. Studija slučaj- kontrola uključila je 100 ispitanika sa patohistološki potvr­đenim gliomom u Kliničkom centru Kragujevac, Srbija, između 2015. i 2016. godine i 200 ispitanika kontrolne grupe, uparenih po polu i uzrastu, koji nisu imali istoriju glioma i drugih malignih bolesti u ličnoj i porodičnoj anamnezi. Nakon potpisivanja informisanog pristanka, svi bolesnici su popunili epidemiološki upitnik. Za obradu statističkih podataka korišćena je multivarijantna logistička regresija. Rezultati. Maligne bolesti su bile češće u stu­dijskoj, nego u kontrolnoj grupi [odds ratio (OR) = 1,821, 95% confidence interval (CI) = 1,004–3,305; p = 0,049]. Najčešći maligni tumori u studijskoj grupi su bili karcinom materice (7%) i karcinom debelog creva (6%), dok su u kontrolnoj grupi najčešći karcinomi bili karcinom pluća (6%) i karcinom materice (7%). Šećerna bolest u porodičnoj anamnezi je bila češća kod bolesnika kontrolne grupe nego kod bolesnika sa gliomom (OR = 0,520, 95% CI = 0,271–0,995; p = 0,048). Takođe, naši rezultati su pokazali da su kardiovaskularne bolesti u porodičnoj anamnezi bile češće u kontrolnoj grupi nego u studijskoj grupi (OR = 0,557, 95% CI = 0,325–0,953; p = 0,033). Zaključak. U ovoj studiji slučaj-kontrola, pronašli smo statistički značajnu vezu između poro­dične istorije malignih bolesti i glioma. Takođe, pronašli smo statistički značajnu inverznu vezu između porodične istorije kardiovaskularnih bolesti i šećerne bolesti i glioma.

Biografija autora

Ana Azanjac Arsić, University of Kragujevac, Faculty of Medical Sciences, Department of Neurology

doktor medicine

saradnik u nastavi na Katedri za neurologiju

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Objavljeno
2021/05/21
Broj časopisa
Vol. 77 Br. 4 (2020): Vojnosanit Pregl
Rubrika
Originalni članak