Pušenje, alkohol i humani papiloma virus kao faktori rizika od razvoja oralnih i orofaringealnih tumora u Srbiji – pilot studija
Sažetak
Uvod/Cilj. Karcinomi usne duplje i orofaringealne regije su među najčešćim malignitetima u svetu. Cilj ove studije bio je da utvrdi faktore rizika od pojave oralnih i orofaringealnih tumora kod bolesnika u Srbiji. Metode. Studijom su bila obuhvaćena 63 bolesnika sa patohistološkom potvrdom malignih lezija (33 bolesnika) i benignih lezija (30 bolesnika) u usnoj duplji/orofaringealnoj regiji. Uvidom u medicinsku dokumentaciju dobijeni su podaci o demografskim karakteristikama (pol i starost) i navikama bolesnika (pušenje i konzumacija alkohola). Tehnikom in situ hibridizacije identifikovan je humani papilomavirus (HPV) u tkivima tumora oralne i orofaringealne regije, fiksiranim u formalinu i ukalupljenim u parafin. Rezultati. Maligne lezije su bile statistički značajno češće kod muškaraca koji su konzumirali alkohol i duvan. Infekcija HPV bila je češća kod bolesnika sa malignim lezijama u odnosu na bolesnike sa benignim lezijama, ali bez statistički značajne razlike. Visokoonkogeni tipovi 16/18 otkriveni su samo kod bolesnika sa malignim lezijama i to tonzila i baze jezika, dok su niskoonkogeni tipovi 6/11 identifikovani kod bolesnika sa benignim lezijama. Zaključak. Rezultati ove pilot studije ukazuju na povezanost pušenja, konzumacije alkohola i visokoonkogenih tipova HPV sa razvojem karcinoma usne duplje i orofaringealne regije kod bolesnika u Srbiji.
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