Značaj citogenetički rizičnih kategorija i prerađenog Međunarodnog prognoznog sistema za procenu ukupnog preživljavanja u primarnoj mijelofibrozi: iskustvo jednog centra

  • Djordje Taušan Klinika za pulmologiju
  • Zoran Kostić Military Medical Academy, Clinic for General Surgery ; University of Defence, Faculty of Medicine of Military Medical Academy
  • Damjan Slavković Military Medical Academy, Clinic for General Surgery
  • Branimir Nešković Military Medical Academy, Clinic for General Surgery
  • Dubravko Bokonjić University of Defence, Faculty of Medicine of Military Medical Academy
  • Sandra Šipetić-Grujičić University of Belgrade, Faculty of Medicine, Institute of Epidemiology
  • Nenad Ratković University of Defence, Faculty of Medicine of Military Medical Academy; Military Medical Academy, Clinic for Emergency Internal Medicine
  • Vesna Šuljagić Military Medical Academy, Department of Nosocomial Infections Control, University of Defence, Faculty of Medicine of Military Medical Academy
DOI: https://doi.org/10.2298/VSP180521125T
Ključne reči: infekcija, intrahospitalna;, pneumonija;, hirurgija digestivnog sistema, procedure;, faktori rizika;, incidenca;, mortalitet

Sažetak


Uvod/Cilj. Primarna mijelofibroza (PMF) je hronična, ma­ligna hematološka bolest koja se karakteriše leukoeritro­blastnom krvnom slikom, anizopoikilocitozom eritrocita u obliku suze, različitim stepenom fibroze kostne srži i hepa­tosplenomegalijom usled ekstramedularne hematopoeze. Od genetičkih specifičnosti bolesti, ističu se hromozomske abe­racije u patološkim, mijeloidnim ćelijama krvi. Cilj rada bio je da se ispita prognostički značaj kliničkih, hemato­loš­kih i citogenetičkih parametara u PMF. Metode. Retrospek­tivnom studijom su bila obuhvaćena 144 bolesnika sa PMF. Analiza kariotipa vršena je konvencionalnom citogene­tičkom meto­dom. Rezultati. Hromozomska analiza je bila uspešna kod 126 (88%) bolesnika, a neuspešna kod ostalih bolesnika (12%). Aberantan kariotip je bio registrovan kod 36/126 (29%) ispitanika na prezentaciji. Najčešće aberacije bile su: +9, 13q- i 20q- (28%). Druge abnormalnosti bile su: aberacije hromo­zoma 18 i 16, delecije (9q-, 12p-,7q-, 5q-, 6q-, 8q-), trizomije (+1q, +8, +10, +21), monozomije (-7, -11), inverzija 3q i gubitak Y hromozoma. Otkrili smo i četri nove balansirane translokacije u PMF: t(17;22)(q11;q13), t(15;17)(q22;q25), t(9;12)(q22;q24) i t(2;4)(q21;p16), jednu konstitucionu trans­lokaciju ˗ rob(13;14)(q10;q10) i neke nove anomalije kariotipa ˗ delecija oba, homologa hromo­zo­ma, hiperdiploidiju i koegzi­stenciju nepovezanih patoloških klonova. Zaključak. Prema citogenetički prerađenom Me­đunarodnom prognoznom sis­temu hromozomske aberacije su statistički značajno (p = 0.004) uticale na ukupno preživ­ljavanje bolesnika sa PMF. Kod naših bolesnika nađene su hromozomske aberacije uobičajne za PMF, ali su registro­vane i nove balansirane translokacije, kao i druge, retke kariotipske anomalije.

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Objavljeno
2021/05/06
Broj časopisa
Vol. 77 Br. 5 (2020): Vojnosanit Pregl
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Originalni članak