Nemelanomski karcinomi kože u Srbiji (1999–2015) – potreba za nacionalnom strategijom za prevenciju i kontrolu
Sažetak
Uvod/Cilj. Nemelanomski karcinomi kože (engl. non-melanoma skin cancers – NMSC) su jedni od najbrže rastućih karcinoma širom sveta. Iako imaju relativno nisku stopu smrtnosti, zbog cene koja je potrebna za njihovo lečenje, predstavljaju veliku brigu u javnom zdravlju mnogih država. Ova studija imala je dva osnovna cilja: prvi, da analizira trend standardizovane incidencije NMCS u Srbiji i drugi, da se na osnovu anliziranog trenda proceni potreba za izradu nacionalne strategije za prevenciju i kontrolu ovog karcinoma. Metode. Iz Registra za rak Srbije izdvojeni su svi slučajeve NMCS registrovani u centralnoj Srbiji od 1. januara 1999 do 3. decembra 2015. godine. Trend kretanja i godišnji procenat promene incidencije (engl. annual percentage change –APC) izračunat je regresionom analizom pomoću tačke spajanja. Rezultati. NMCS su se značajno povećavali kod oba pola sa APC od +2,32% (p < 0,001). Značajno povećanje trenda incidencije je bilo veće kod žena (APC, +2.63%; p < 0,0001) nego kod muškaraca (APC, +2.01%; p < 0,001). Zaključak. Rezultati pokazuju kontinuirano povećanje stope incidencije NMCS u Srbiji. Bez nacionalne preventivne strategije vrlo je malo verovatno da će sadašnje sporadične preventivne aktivnosti smanjiti ovaj rastući trend.
Reference
Fahradyan A, Howell AC, Wolfswinkel EM, Tsuha M, Sheth P, Wong AK. Updates on the Management of Non-Melanoma Skin Cancer (NMSC). Healthcare (Basel) 2017; 5(4): pii: E82.
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality pat-terns in Europe: estimates for 40 countries in 2012. Eur J Cancer 2013; 49(6): 1374‒403.
Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol 2012; 166(5): 1069‒80.
Adelson P, Sharplin GR, Roder DM, Eckert M. Keratinocyte cancers in South Australia: incidence, geographical variabil-ity and service trends. Aust N Z J Public Health 2018; 42(4): 329‒33.
Ahluwalia J, Hadjicharalambous E, Mehregan D. Basal cell carci-noma in skin of color. J Drugs Dermatol 2012; 11(4): 484‒6.
Rogers HW, Weinstock MA, Feldman SR, Coldiron BM. Inci-dence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the US population, 2012. JAMA Derma-tol 2015; 151(10): 1081‒6.
Yu SL, Lee SK. Ultraviolet radiation: DNA damage, repair, and human disorders. Molec Cell Toxicol 2017; 13(1): 21‒8.
Amaro-Ortiz A, Yan B, D'Orazio JA. Ultraviolet radiation, ag-ing and the skin: prevention of damage by topical cAMP manipulation. Molecules 2014; 19(5): 6202‒19.
Bauer A, Diepgen TL, Schmitt J. Is occupational solar ultravio-let irradiation a relevant risk factor for basal cell carcinoma? A systematic review and meta-analysis of the epidemiologi-cal literature. Br J Dermatol 2011; 165(3): 612‒25.
Schmitt J, Seidler A, Diepgen TL, Bauer A. Occupational ultra-violet light exposure increases the risk for the development of cutaneous squamous cell carcinoma: a systematic review and meta-analysis. Br J Dermatol 2011; 164(2): 291‒307.
Wehner MR, Shive ML, Chren M-M, Han J, Qureshi AA, Linos E. Indoor tanning and non-melanoma skin cancer: system-atic review and meta-analysis. BMJ 2012; 345: e5909.
Qin J, Holman DM, Jones SE, Berkowitz Z, Guy GP Jr. State In-door Tanning Laws and Prevalence of Indoor Tanning Among US High School Students, 2009-2015. Am J Public Health 2018; 108(7): 951‒6.
Fitzpatrick TB. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 1988; 124(6): 869-71.
Shih STF, Carter R, Heward S, Sinclair C. Skin cancer has a large impact on our public hospitals but prevention pro-grams continue to demonstrate strong economic creden-tials. Aust N Z J Public Health 2017; 41(4): 371‒6.
Mofidi A, Tompa E, Spencer J, Kalcevich C, Peters CE, Kim J, et al. The economic burden of occupational non-melanoma skin cancer due to solar radiation. J Occup Environ Hyg 2018; 15(6): 481‒91.
Housman TS, Feldman SR, Williford PM, Fleischer AB Jr, Gold-man ND, Acostamadiedo JM, et al. Skin cancer is among the most costly of all cancers to treat for the Medicare popula-tion. J Am Acad Dermatol 2003; 48(3): 425‒9.
Perera E. Public health strategies for preventing non mela-noma skin cancers . Global Dermatol 2014; 1(2): 36‒8.
Videnović G, Miljuš D, Ilić D, Krasić D, Živković S. Nonmela-noma Skin Cancer in the Population of the City of Bel-grade in the Period 1999-2011. Srp Arh Celok Lek 2015; 143(5‒6): 290‒5.
Braun RP, Ulrich K, Hunger R, Gaide O, Arnold A, Merat R, et al. Evaluation of the National Swiss Skin Cancer Screening Campaign 2013: Do We Do the Right Thing. Dermatolo-gy 2017; 233(5): 404‒9.
Stratigos AJ, Forsea AM, van der Leest RJ, De Vries E, Nagore E, Bulliard JL, et al. Euromelanoma: a dermatology-led Euro-pean campaign against nonmelanoma skin cancer and cu-taneous melanoma. Past, present and future. Br J Dermatol 2012; 167(Suppl 2): 99‒104.
Del Marmol V. The Euromelanoma campaign. Actas Der-mosifiliogr 2016; 107(5): 365. (English, Spanish)
Antonijevic A, Rancic N, Ilic M, Kocic B, Stevanovic J, Milic M. Trends in incidence of non-melanoma and melanoma skin cancers in central Serbia. Srp Arh Celok Lek. 2018; 146(7‒8): 391‒5.
World Health Organization. International Statistical Classifica-tion of Diseases. 10th revision (ICD-10). Geneva: World Health Organization; 2008.
Jensen OM, Parkin DM, Maclennan R, Muir CS, Skeet RG. Can-cer Registration: Principles and Methods. Lyon: Interna-tional Agency for Research on Cancer; 1991.
Sinclair R. Nonmelanoma skin cancer in Australia. Br J Dermatol 2013; 168: 1‒2.
Martín-García E, Arias-Santiago S, Serrano-Ortega S, Buendía-Eisman A. Changes in the Incidence of Skin and Lip Can-cer Between 1978 and 2007. Actas Dermosifiliogr 2017; 108(4): 335‒45. (Spanish)
Eisemann N, Waldmann A, Geller AC, Weinstock MA, Volkmer B, Greinert R. Non-melanoma skin cancer incidence and impact of skin cancer screening on incidence. J Invest Dermatol 2014; 134(1): 43‒50.
Deady S, Sharp L, Comber H. Increasing skin cancer inci-dence in young, affluent, urban populations: a challenge for prevention. Br J Dermatol 2014; 171(2): 324‒31.
Ceylan C, Oztürk G, Alper S. Non-melanoma skin cancers be-tween the years of 1990 and 1999 in Izmir, Turkey: demo-graphic and clinicopathological characteristics. J Dermatol 2003; 30(2): 123‒31.
Harrison SL, Garzón-Chavez DR, Nikles CJ. Sun protection policies of Australian primary schools in a region of high sun exposure. Health Educ Res 2016; 31(3): 416‒28.
Jones SB, Beckmann K, Rayner J. Australian primary schools’ sun protection policy and practice: evaluating the impact of the National SunSmart Schools Program. Health Promot J Austr 2008;19: 86‒90.
Miljković S, Baljozović D, Krajnović D, Tasić L, Sbutega-Milosević G. The impact of education on adolescents' sun behavior: experiences from Serbia. Srp Arh Celok Lek 2014; 142(5‒6): 330‒6.
Kim RH, Armstrong AW. Nonmelanoma skin cancer. Der-matol Clin 2012; 30 1): 125‒39, ix.
Leiter U, Keim U, Eigentler T, Katalinic A, Holleczek B, Martus P. Incidence, Mortality, and Trends of Nonmelanoma Skin Cancer in Germany. J Invest Dermatol 2017; 137(9): 1860‒7.
Lipozencić J, Celić D, Strnad M, Toncić RJ, Pasić A, Rados J. Skin cancers in Croatia, 2003-2005: epidemiological study. Coll Antropol 2010; 34(3): 865‒9.
Brougham ND, Dennett ER, Tan ST. Changing incidence of non-melanoma skin cancer in New Zealand. ANZ J Surg 2011; 81(9): 633‒6.
Demers AA, Nugent Z, Mihalcioiu C, Wiseman MC, Kliewer EV. Trends of nonmelanoma skin cancer from 1960 through 2000 in a Canadian population. J Am Acad Dermatol 2005; 53(2): 320‒8.
Heidari M, Najafi F. Trends of skin cancer incidence in 6 geographical regions of the Islamic Republic of Iran, 2000-2005. East Mediterr Health J 2013; 19(1): 59‒65.
Zeb A, Rasool A, Nasreen S. Cancer incidence in the districts of Dir (North West Frontier Province), Pakistan: a prelim-inary study. J Chin Med Assoc 2008; 71(2): 62‒5.
Hollestein LM, De Vries E, Nijsten T. Trends of cutaneous squamous cell carcinoma in the Netherlands: increased in-cidence rates, but stable relative survival and mortality 1989-2008. Eur J Cancer 2012; 48(13): 2046‒53.
Birch-Johansen F, Jensen A, Mortensen L, Olesen AB, Kjaer SK. Trends in the incidence of nonmelanoma skin cancer in Denmark 1978-2007: rapid incidence increase among young Danish women. Int J Cancer 2010; 127(9): 2190‒8.
Boi S, Cristofolini M, Micciolo R, Polla E, Dalla Palma P. Epide-miology of skin tumours: data from the cutaneous cancer registry in Trentino, Italy. J Cutan Med Surg 2003; 7(4): 300‒5.
Levi F, Te VC, Randimbison L, Erler G, La Vecchia C. Trends in skin cancer incidence in Vaud: an update, 1976-1998. Eur J Cancer Prev 2001; 10(4): 371‒3.
Lee G, Ko NY, Son SW, Bae HJ, Ha JS, Pak HY, et al. The impact of ozone depletion on skin cancer incidence in Ko-rea. Br J Dermatol 2013; 169(5): 1164‒5.
De Vries E, van de Poll-Franse LV, Louwman WJ, de Gruijl FR, Coebergh JW. Predictions of skin cancer incidence in the Netherlands up to 2015. Br J Dermatol 2005; 152(3): 481‒8.
Pawlak MT, Bui M, Amir M, Burkhardt DL, Chen AK, Del-lavalle RP. Legislation restricting access to indoor tanning throughout the world. Arch Dermatol 2012; 148(9): 1006‒12.
Bataille V, Boniol M, De Vries E, Severi G, Brandberg Y, Sasieni P, et al. A multicentre epidemiological study on sunbed use and cutaneous melanoma in Europe. Eur J Cancer 2005; 41(14): 2141‒9.
Karagas MR, Stannard VA, Mott LA, Slattery MJ, Spencer SK, Weinstock MA. Use of tanning devices and risk of basal cell and squamous cell skin cancers. J Natl Cancer Inst 2002; 94(3): 224‒6.
Keim U, van der Pols JC, Williams GM, Green AC. Exclusive development of a single type of keratinocyte skin cancer: evidence from an Australian population-based cohort study. J Invest Dermatol 2015; 135(3): 728‒33.
Hoey SE, Devereux CE, Murray L, Catney D, Gavin A, Kumar S, et al. Skin cancer trends in Northern Ireland and conse-quences for provision of dermatology services. Br J Derma-tol 2007; 156(6): 1301‒7.
Stang A, Ziegler S, Büchner U, Ziegler B, Jöckel KH, Ziegler V. Malignan melanoma and nonmelanoma skin cancers in Northrhine-Westphalia, Germany: a patient- vs. diagnosis-based incidence approach. Int J Dermatol 2007; 46(6): 564‒70.