Tumori pluća: rana i odložena akumulacija 99mTc-metoksi-2-izobutilizonitrila

Katarina Nikoletić; Jasna Mihailović; Dolores Srbovan; Violeta Kolarov; Radmila Žeravica

doi:10.2298/2361

Katarina Nikoletić Department of Nuclear Medicine, Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Jasna Mihailović Department of Nuclear Medicine, Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Dolores Srbovan Department of Nuclear Medicine, Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Violeta Kolarov Department of General Pulmology, Institute of Pulmonary Diseases, Sremska Kamenica, Serbia
Radmila Žeravica Department of Nuclear Medicine, Clinical Center of Vojvodina, Novi Sad, Serbia

DOI: https://doi.org/10.2298/2361

Ključne reči: radiopharmaceuticals||, ||radiofarmaci, tomography, emission-computed||, ||tomografija, kompjuterizovana, emisiona, lung neoplasms||, ||pluća, neoplazme, diagnosis, differential||, ||dijagnoza, diferencijalna, pathology||, ||patologija, sensitivity and specificity||, ||osetljivost i specifičnost,

Sažetak

Uvod/Cilj. Novi radiofarmaceutici su nespecifični i većina njih se akumuliše u benignim tumorima, ali i u zapaljenskim lezijama, apscesima ili granulomatoznim lezijama. Na senzitivnost snimaka tumora utiču razni faktori kao što su izbor radiofarmaceutika, patohistološki tip tumora, veličina, lokalizacija ili način lečenja. Cilj ove studije bio je da se proceni nakupljanje ^99mTc-metoksi-2-izobutilizonitrila (^99mTc-MIBI) unutar tumora pluća određivanjem rane/odložene akumulacije, odnosno eliminacije ^99mTc-MIBI, kao i da se utvrde mogući faktori koji bi mogli uticati na akumulaciju ovog radiofarmaceutika. Metode. Dvofazna ^99mTc-metoksi-2-izobutilizonitril jednofotonska emisiona kompjuterizovana tomografija (rana i kasna) urađena je kod 60 bolesnika sa tumorom pluća (grupa 1 – 30 benignih i grupa 2 – 30 malignih tumora). Izračunavali smo odnos nakupljanja na ranim (early ratio – ER) i odloženim snimcima (delayed ratio – DR), kao i indeks retencije (retention index – RI). Regresiona analiza korišćena je u cilju utvrđivanja pojedinačnog uticaja etiologije, veličine, lokalizacije i patohistološkog tipa tumora na vrednosti akumulacije/eliminacije radiofarmaka. Rezultati. Vrednosti ER i DR bile su statistički značajno različite u obe ispitivane grupe (p < 0,01), sa manjim izmerenim vrednostima kod benignih u poređenju sa malignim tumorima (ER 1,36 ± 0,094 i DR 1,25 ± 0,089 vs ER = 1,93 ± 0,106 i DR = 1,7 ± 0,095, respektivno). Utvrđeno je da veličina tumora pluća značajno utiče na promene vrednosti ER i DR (p < 0,01), sa intenzivnijom akumulacijom unutar tumora dimenzija preko 3 cm. Zaključak. Rana i odložena akumulacija ^99mTc-metoksi-2-izobutilizonitrila u tumorima pluća je koristan parametar za njihovu diferencijaciju, dok vrednost indeksa retencije nema uticaja na diferenciranje benignih i malignih tumora pluća. Veličina tumora pluća statistički značajno utiče na vrednosti ER i DR. Ostali ispitivani faktori, kao što su lokalizacija ili patohistološki tip unutar grupe 1 ili grupe 2, ne utiču na vrednosti ER i DR.

Biografija autora

Katarina Nikoletić, Department of Nuclear Medicine, Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia

Institute of Oncology of Vojvodina

Nuclear Medicine Department

Goldmanov put

21204 Sremska Kamenica

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