Diagnostic applications of the "pattern" electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in Parkinson's disease

Jelena Stamenović; Biljana Živadinović; Vanja Djurić; Srdjan Ljubisavljević

doi:10.2298/VSP200126104S

Jelena Stamenović University of Niš, Faculty of Medicine, Niš, Serbia; University Clinical Center of Niš, Clinic for Neurology, Niš, Serbia
Biljana Živadinović University of Niš, Faculty of Medicine, Niš, Serbia; University Clinical Center of Niš, Clinic for Neurology, Niš, Serbia
Vanja Djurić Polyclinic “Neuromedic“, Niš, Serbia
Srdjan Ljubisavljević University of Niš, Faculty of Medicine, Niš, Serbia; University Clinical Center of Niš, Clinic for Neurology, Niš, Serbia

DOI: https://doi.org/10.2298/VSP200126104S

Ključne reči: dijagnoza;, elektroretinografija;, evocirani potencijali, vizuelni;, parkinsonova bolest.

Sažetak

ABSTRACT

Background and Aim: In spite of continuous research efforts, specific laboratory, neuropsychological or neurophysiological tests for the diagnosis of Parkinson’s disease have not been established. The aims of the paper are to determine the impact of visual pathway disorders on “pattern” electroretinogram and visual evoked potentials in certain stages of Parkinson's disease.

Materials and Methods: The study was carried out in a group of 60 persons of both sexes, who were suffering from idiopathic Parkinson's disease at the I-IV stage of the desease according to the Hoehn and Yahr scale, and 30 healthy persons in the control group. The battery of non-invasive neurophysiological tests was used to estimate the functional status of the visual pathway: "pattern" electroretinography (PERG) and visual evoked potentials (VEP).

Results: In the early phase of PB there is a linear increase in the latency of the wave N50 of the "pattern" electroretinogram and the wave P100 of the visual evoked potentials with significant extension of the latency of the N50 and P100 waves in subsequent stages of Parkinson's disease. Diagnostic application of the "pattern" electroretinography and visual evoked potentials enables the confirmation of a disorder in the visual pathway function in Parkinson's disease.

Conclusion: These neurophysiological techniques may record early changes in the function of retinal structures and the optic nerve in PD, which might be significant both from the diagnostic and therapeutic aspects.

Keywords: Parkinson's disease, visual evoked potentials, electroretinogram

ABSTRAKT

Uvod i cilj: Uprkos neprekidnim istraživačkim naporima, specifični laboratorijski, neuropsihološki ili neurofiziološki testovi za dijagnozu Parkinsonove bolesti nisu utvrđeni. Ciljevi rada su utvrditi uticaj poremećaja vidnog puta na „pattern“ elektroretinogram i vizuelne evocirane potencijale u određenim fazama Parkinsonove bolesti.

Materijal i metode: Ispitivanje je sprovedeno u grupi od 60 osoba oba pola, obolelih od idiopatske Parkinsonove bolesti (PB), u I – IV fazi bolesti prema skali Hoehn-ove I Yahr-a, i 30 zdravih osoba u kontrolnoj grupi. Baterija neinvazivnih neurofizioloških testova upotrebljena je za procenu funkcionalnog statusa vizuelnog puta: „pattern“ elektroretinogram (PERG) i vizuelni evocirani potencijali (VEP).

Rezultati: U ranoj fazi PB dolazi do lineranog povećanja latence talasa N50 PERG-a I talasa P100 VEP-a, sa značajnim produženjem latency talasa N50 I P100 u odmaklim fazama PB. Dijagnostička primena PERG-a I VEP-a omogućava potvrđivanje poremećaja funkcije vizuelnog puta kod PB.

Zaključak: Ove neurofiziološke metode mogu registrovati rane promene u funkciji retinalnih struktura I optičkog nerva u PB, koje mogu biti značajne I sa dijagnostičkog I sa terapijskog aspekta.

Ključne reči: Parkinsonova bolest, vizuelni evocirani potencijali,

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