Trabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: a three-year follow-up

  • Ranko Gvozdenović University Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia
  • Ivan Marjanović University of Belgrade, Faculty of Medicine, University Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia
  • Marija Božić University of Belgrade, Faculty of Medicine, Belgrade, Serbia
  • Vesna Marić University of Belgrade, Faculty of Medicine, Belgrade, Serbia
  • Milenko Stojković University of Belgrade, Faculty of Medicine, Belgrade, Serbia
  • Marija Marjanović University of Belgrade, Faculty of Medicine, Belgrade, Serbia
  • Elena Jordanova Clinical Hospital Center Zemun, Clinic for Internal Medicine, Department of Nephrology, Belgrade, Serbia
  • Antonio Martinez Clinical Research Department, Science Research and Sports, Ames, La Coruna, Spain
DOI: https://doi.org/10.2298/VSP200428001M
Ključne reči: glaucoma, open-angle;, mitomycin;, ophthalmologic surgical procedures;, silicone oils;, trabeculectomy.

Sažetak


Background/Aim. Different surgical interventions have been proposed, including trabeculectomy associated with antiproliferative agents because silicone oil (SO) removal cannot necessarily provide intraocular pressure (IOP) control. The aim of the study was to determine the efficacy of trabeculectomy with mitomycin C (MMC) for lowering IOP in patients with open-angle glaucoma (OAG) secondary to emulsified SO after pars plana vitrectomy. Methods. A single-center, prospective study was conducted, from December 2014 to December 2019, on 56 consecutive patients with an uncontrolled elevation of IOP after SO removal who were subjected to trabeculectomy with mitomycin MMC in that period.  The primary end-point was the IOP at the three-year follow-up visit. Complete surgical success was defined as an IOP ranging from 7 mmHg to 18 mmHg without glaucoma medication. Qualified success was defined as IOP ≤ 21 mmHg with one or two topical medications. Results. Fifty-six patients with a mean age of 53.6 [standard deviation (SD)15.5] years had a mean baseline IOP of 42.3 (39.3 to 45.3) mmHg, which reduced to 18.6 (17.9 to 19.3) mmHg three years after surgery (p < 0.0001). Seventeen (30.4%) eyes were classified as a complete success, 21 (37,5%) as a qualified success, and 18 (32.1%) as a failure. In all successfully treated patients, the number of antiglaucoma medications was significantly reduced from 2.85 (SD 0.77) to 1.63 (SD 0.62), p < 0.0001. Conclusion. Trabeculectomy with MMC may be an option for lowering IOP in patients with OAG secondary to emulsified SO after pars plana vitrectomy, which was not controlled with maximum antiglaucomatous medical treatment.

Biografija autora

Ranko Gvozdenović, University Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia

Doktor Medicine

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Objavljeno
2023/01/04
Broj časopisa
Vol. 79 Br. 12 (2022): Vojnosanitetski pregled
Rubrika
Originalni članak