Veliki hemangiopericitom ramenog pojasa
Sažetak
Uvod. Hemangiopericitom je redak tumor porekla pericita, kontraktilnih vretenastih ćelija koje okružuju kapilare i postkapilarne venule. Tumor se javlja podjednako u muškoj i ženskoj populaciji. Prikaz bolesnika. Prikazana je 63-godišnja bolesnica sa džinovskom bolnom promenom na desnom ramenu, primećenu godinu dana pre prijema. Žalila se na ograničen opseg pokreta kao i osećaj trnjenja u zahvaćenoj ruci. Promena je bila nepravilno ovalnog oblika, tamnocrvene boje, sa znakovima nekroze, maksimalnog prečnika 14 cm. Rutinske laboratorijske analize pokazale su rezultate u granicama referentnih vrednosti. Rendgenski snimak pluća i ultrasonografski pregled abdomena nisu pokazali znakove sekundarnih depozita tumora, kao ni osteomišićne lezije u zahvaćenom regionu. Ultrazvučni pregled vrata i desne aksilarne regije nije pokazao znakove regionalnih metastaza. Izvršena je hirurška ekscizija celog tumora sa pripadajućim potkožnim tkivom i delom fascije ispod. Rezultati histopatološke analize potvrdili su dijagnozu hemangiopericitoma. Uzorak nije pokazao znakove ili elemente neoplastičnog tkiva na ivicama resekcionih linija, a 3 godine nakon operacije nisu bilo znakova relapsa tumora, regionalnih ili sistemskih metastaza. Zaključak. S obzirom na činjenicu da ne postoje zvanični klinički vodiči i protokoli za lečenje hemangiopericitoma, kao i da je pojava kožnih i potkožnih hemangiopericitoma izuzetno retka, potrebno je opsežnije istraživanje na ovu temu i više prikaza slučajeva da bi se steklo bolje razumevanje problema.
Reference
Stout AP, Murray MR. Hemangiopericytoma: A vascular tumor featuring Zimmermann’s pericytes. Ann Surg 1942; 116(1): 26‒33.
Cangiarella J, Simsir A, Tabbara SO. Breast cytohistology. Cambridge: Cambridge University Press; 2013.
Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol 2005; 7(4): 452‒64.
Fountoulakis EN, Papadaki E, Panagiotaki I, Giannikaki E, Lagoudianakis G, Bizakis J. Primary haemangiopericytoma of the parapharyngeal space: an unusual tumour and review of the literature. Acta Otorhinolaryngol Ital 2011; 31(3): 194‒8.
Bicakcioglu P, Aydin E, Celik A, Demirag F, Karaoglanoglu N. Primary classical hemangiopericytomas of thorax. Ann Thoracic Surg 2012; 94(1): 255‒9.
Zielinska-Kazmierska B, Grodecka J, Teodorczyk-Werfel D, Milcarz R. The midfacial glomangiopericytoma – Case report. J Oral Biol Craniofac Res 2015; 5(2): 124‒6.
Goldberger RE, Schein CJ. Hemangiopericytoma of the omentum. Report of a case with unique presentation and review of the literature. Am Surg 1968; 34(4): 291‒5.
Murray MR, Stout AP. Glomus Tumor: Investigation of its distribution and behavior, and the Identity of its "Epithelioid" Cell. Am J Pathol 1942; 18(2): 183‒203.
Fuste FJ. Primary hemangiopericytoma of the orbit. J Tenn Med Assoc 1968; 61(10): 1003‒5.
Feldman F, Seaman WB. Primary thoracic hemangiopericytoma. Radiology 1964; 82: 998‒1009.
Wushou A, Miao XC, Shao ZM. Treatment outcome and prognostic factors of head and neck hemangiopericytoma: Meta-analysis. Head Neck 2015; 37(11): 1685‒90.
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007; 114(2): 97‒109.
Tauro LF, George C, Kamath A, Sundaran S, Gatty R. Hemangiopericytoma of the hand. Indian J Surg Oncol 2013; 4(1): 76‒9.
Kendre P , Kataria P, Patel A, Gaurav L, Dalsaniya S. Hemangiopericytoma of supraglottis: A rare case report and review of literature. J Cancer Res Ther 2019; 15(3): 729‒32.
Kowalski PJ, Paulino AF. Proliferation index as a prognostic marker in hemangiopericytoma of the head and neck. Head Neck 2001; 23(6): 492‒6.
Enzinger FM, Smith BH. Hemangiopericytoma. An analysis of 106 cases. Hum Pathol 1976; 7(1): 61‒82.
Benn JJ, Firth RG, Sönksen PH. Metabolic effects of an insulin-like factor causing hypoglycaemia in a patient with a hemangiopericytoma. Clin Endocrinol (Oxf) 1990; 32(6): 769‒80.
Li J, Huang Y, Yang F, Zhang Q, Chen D, Wang Q. Sinonasal hemangiopericytoma caused hypophosphatemic osteomalacia: A case report. Medicine (Baltimore) 2018; 97(52): e13849.
Mayou SC, Benn JJ, Sönksen PH, Black MM. Paraneoplastic rhinophyma and the Leser-Trélat sign. Clin Exp Dermatol 1989; 14(3): 253‒5.
Weiss SW. Benign hemangiopericytoma. In: Weiss SW, Sobin LH and pathologists in 9 countries, editors. Histological Typing of Soft Tissue Tumours (WHO. World Health Organization. International Histological Classification of Tumours (Paperback). Chapter: Perivascular tumors. 2nd ed. New York, Berlin, Heidelberg: Springer-Verlag; 1994.
Joo MS, Rho YJ, Song SW, Koh YC, Roh HG, Lim SD. Metastatic Intracranial Hemangiopericytoma to the Spinal Column: A Case Report. Brain Tumor Res Treat 2016; 4(2): 128‒32.
Goldblum JR, Weiss SW, Folpe AL. Solitary Fibrous Tumor (Hemangiopericytoma). In: Goldblum JR, Weiss SW, Folpe AL, editors. Enzinger and Weiss’s Soft Tissue Tumors. 7th ed. Chapter: Soft Tissue Tumors of Intermediate Malignancy of Uncertain Type. London: Elsevier; 2019. p. 32.
Proietti A, Sartori C, Torregrossa L, Vitti P, Aghababyan A, Fregoli L, et al. A case of metastatic haemangiopericytoma to the throid gland: Case Report and literature review. Oncol Lett 2012; 3(6): 1255‒8.
Slupski M, Piotrowiak I, Wlodarczyk Z. Local recurrence and distant metastases 18 years after resection of the greater omentum hemangiopericytoma. World J Surg Oncol 2007; 5: 63.
Shaigany K, Fang CH, Patel TD, Park RC, Baredes S, Eloy JA. A population-based analysis of head and neck hemangiopericytoma. Laryngoscope 2016; 126(3): 643‒50.