Prvi slučaj izolovane metastaze primarnog karcinoma prelaznih ćelija jajnika u slezinu
Sažetak
Uvod. Primarni karcinom prelaznih ćelija (KPĆ) jajnika karakteriše prisustvo papilarnih projekcija malignih ćelija prelaznog epitela ili njihovih agregata u fibroznoj stromi. Ovaj tip tumora obuhvata oko 1% svih karcinoma površinskog epitela jajnika. Prikazali smo prvi slučaj solitarne metastaze primarnog ovarijalnog KPĆ u slezinu. Prikaz bolesnika. Bolesnica stara 60 godina primljena je u decembru 2018. godine, zbog asimptomatskog tumora slezine. Dve godine ranije joj je zbog primarnog KPĆ jajnika urađena totalna abdominalna histerektomija, bilateralna adneksektomija i infrakolična omentektomija. Kontrolna ultrasonografija abdomena, kompjuterizovana tomografija i magnetna rezonanca, sprovedene dve godine nakon operacije, pokazale su tumor slezine. Urađena je otvorena splenektomija, a intraoperativni nalaz je pokazao tumor hilusa slezine, bez drugih patoloških lezija u abdomenu. Patohistološka analiza je pokazala metastazu KPĆ, što je potvrđeno naknadnom definitivnom patohistološkom analizom. U toku jednogodišnjeg praćenja nije bilo relapsa bolesti. Zaključak. Prema literaturnim podacima ovo je prvi prikazani slučaj solitarne metastaze primarnog KPĆ jajnika u slezinu, koji može predstavljati primer dijagnostičke i terapijske uloge splenektomije kod izolovanih metastaza karcinoma jajnika u slezinu.
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1. Badin J, Abello A, Gupta M, Das AK. Urothelial Carcinoma of the Bladder With a Rare Solitary Metastasis to the Ovary. Urology 2020; 135: 24‒7.
2. Cuatrecasas M, Catasus L, Palacios J, Prat J. Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas. Am J Surg Pathol 2009; 33(4): 556‒67.
3. Weinberger V, Minář L, Felsinger M, Ovesná P, Bednaříková M, Číhalová M, et al. Brenner tumor of the ovary – ultrasound features and clinical management of a rare ovarian tumor mimicking ovarian cancer. Ginekol Pol 2018; 89(7): 357‒63.
4. Giordano G, D'Adda T, Gnetti L, Merisio C, Raboni S. Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. Int J Gynecol Pathol 2007; 26(3): 298‒304.
5. Austin RM, Norris HJ. Malignant Brenner tumor and transitional cell carcinoma of the ovary: a comparison. Int J Gynecol Pathol 1987; 6(1): 29‒39.
6. Chandanwale SS, Kamble T, Mishra N, Kumar H, Jadhav R. A pure primary transitional cell carcinoma of the ovary: A rare case report with literature review. Int J Appl Basic Med Res 2016; 6(2): 140‒2.
7. Kommoss F, Kommoss S, Schmidt D, Trunk MJ, Pfisterer J, du Bois A, et al. Survival benefit for patients with advanced-stage transitional cell carcinomas vs. other subtypes of ovarian carcinoma after chemotherapy with platinum and paclitaxel. Gynecol Oncol 2005; 97(1): 195‒9.
8. Eichhorn JH, Young RH. Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis. Am J Surg Pathol 2004; 28(4): 453‒63.
9. Logani S, Oliva E, Amin MB, Folpe AL, Cohen C, Young RH. Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers: histogenetic and diagnostic implications. Am J Surg Pathol 2003; 27(11): 1434‒41.
10. Ichigo S, Takagi H, Matsunami K, Murase T, Ikeda T, Imai A. Transitional cell carcinoma of the ovary (Review). Oncol Lett 2012; 3(1): 3-6. (English)
11. Silva EG, Robey-Cafferty SS, Smith TL, Gershenson DM. Ovarian carcinomas with transitional cell carcinoma pattern. Am J Clin Pathol 1990; 93(4):457-65.
12. Keepanasseril A, Suri V, Gupta N, Ghoshal S. Transitional cell carcinoma of the ovary: unusual presentation as metastatic cervical lymph node. J Obstet Gynaecol Res 2008; 34(4 Pt 2): 696‒8.
13. Ghani AA, Hashmi ZA, Chase DM, Patel SB, Jones DF. Intraparenchymal metastases to the spleen from ovarian cancer: a case report. J Med Case Rep 2010; 4: 30.
14. Farias-Eisner R, Braly P, Berek JS. Solitary recurrent metastasis of epithelial ovarian cancer in the spleen. Gynecol Oncol 1993; 48(3): 338‒41.
15. Izuishi K, Sano T, Usuki H, Okano K, Masaki T, Kushida Y, et al. Isolated splenic metastasis of ovarian cancer 20 years after operation: a case report and literature review. Tumori 2010; 96(5): 784‒6.
16. Gemignani ML, Chi DS, Gurin CC, Curtin JP, Barakat RR. Splenectomy in recurrent epithelial ovarian cancer. Gynecol Oncol 1999; 72(3): 407‒10.
17. Yano H, Iwazawa T, Kinuta M, Nakano Y, Tono T, Matsui S, et al. Solitary splenic metastasis from ovarian cancer successfully treated by hand-assisted laparoscopic splenectomy: report of a case. Surg Today 2002; 32(8): 750‒2.
18. Koh YS, Kim JC, Cho CK. Splenectomy for solitary splenic metastasis of ovarian cancer. BMC Cancer 2004; 4(1): 96.
19. Tserkezoglou A, Kontou S, Hatjieleftheriou G, Nikolaidou ME, Plataniotis G, Apostolikas N, et al. Solitary parenchymal splenic recurrence of ovarian adenocarcinoma: a case report and review of the literature. Anticancer Res 2005; 25(2B): 1471‒6.
20. Otrock ZK, Seoud MA, Khalifeh MJ, Makarem JA, Shamseddine AI. Laparoscopic splenectomy for isolated parenchymal splenic metastasis of ovarian cancer. Int J Gynecol Cancer 2006; 16(5): 1933‒5.
21. Karni D, Kopelman D, Abu Hatoum O. Solitary splenic metastasis of ovarian carcinoma: a case report. J Med Case Rep 2014; 8: 154.
22. Lee DH, Yoon JK, Lee SJ, Jo KS, Yoon SH, An YS. Isolated splenic metastasis of ovarian cancer detected with 18F-FDG PET/CT. Clin Nucl Med 2014; 39(4): 349‒51.
23. Resta G, Vedana L, Marino S, Scagliarini L, Bandi M, Anania G. Isolated splenic metastasis of ovaric cancer. Case report and literature review. G Chir 2014; 35(7‒8): 181‒4.
24. Lv M, Li Y, Luo C, Liu P, Yang J. Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature. Exp Ther Med 2014; 7(4): 982‒6.
25. Sorbi F, Prosperi P, Villanucci A, Berti V, Sisti G, Fambrini M. Laparoscopic Splenectomy as Quaternary Cytoreduction for Isolated Parenchymal Splenic Recurrence of Epitelial Tubo-Ovarian Cancer: Report of a Case and Literature Review. Gynecol Obstet Invest 2015; 80(4): 265‒71.
26. Max LD, Stastny JF, Frable WJ. Solitary splenic metastasis of an adenocarcinoma of the ovaries. Gynecol Obstet Invest 1996; 42(3): 214‒6.
27. Tazi EM, Lalya I, Tazi MF, Ahellal Y, M'rabti H, Errihani H. Transitional cell carcinoma of the ovary: a rare case and review of literature. World J Surg Oncol 2010; 8: 98. (English)
28. Lee M, Jung YW, Kim SW, Kim SH, Kim YT. Metastasis to the ovaries from transitional cell carcinoma of the bladder and renal pelvis: a report of two cases. J Gynecol Oncol 2010; 21(1): 59‒61.
29. Coffman LG, Burgos-Ojeda D, Wu R, Cho K, Bai S, Buckanovich RJ. New models of hematogenous ovarian cancer metastasis demonstrate preferential spread to the ovary and a requirement for the ovary for abdominal dissemination. Transl Res 2016; 175: 92‒102. e2.
30. Yousefi M, Dehghani S, Nosrati R, Ghanei M, Salmaninejad A, Rajaie S, et al. Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles. Cell Oncol 2020; 43(4): 515‒38.
31. Giannopoulou L, Kasimir-Bauer S, Lianidou ES. Liquid biopsy in ovarian cancer: recent advances on circulating tumor cells and circulating tumor DNA. Clin Chem Lab Med 2018; 56(2): 186‒97.
32. Ramalingam P. Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer. Oncology (Williston Park) 2016; 30(2): 166‒76.