Lymphoma of the uterine cervix – a rare clinical presentation

Dušica Petrović Rodić; Tatjana Kastratović; Danijela  Jovanović; Vladan Marković; Jasmina Stojanović; Dalibor Jovanović

doi:10.2298/VSP210707080P

Dušica Petrović Rodić University of Kragujevac, Faculty of Medical Sciences, Department of Pathology, Kragujevac, Serbia
Tatjana Kastratović University Medical Center Kragujevac, Department of Gynecology and Obstetrics, Kragujevac, Serbia
Danijela Jovanović University of Kragujevac, Faculty of Medical Sciences, Department of Internal Medicine, Kragujevac, Serbia
Vladan Marković University of Kragujevac, Faculty of Medical Sciences, Department of Radiology, Kragujevac, Serbia
Jasmina Stojanović University of Kragujevac, Faculty of Medical Sciences, Department of Otorhinolaryngology, Kragujevac, Serbia
Dalibor Jovanović University of Kragujevac, Faculty of Medical Sciences, Department of Pathology, Kragujevac, Serbia

DOI: https://doi.org/10.2298/VSP210707080P

Ključne reči: biopsija, limfom, nehodžkinov, papillomaviridae, serotipizacija, grlić materice, displazija

Sažetak

Uvod. Limfomi su maligne bolesti limfocitne loze. Postoje dva osnovna tipa limfoma: Hodgkin-ov limfom (HL), čija je osnovna karakteristika prisustvo Reed-Sternberg-ovih ćelija, i non-Hodgkin-ov limfom (NHL), koji predstavlja heterogenu grupu bolesti, a u zavisnosti od brzine rasta i toka bolesti mogu biti indolentni (spororastući tok) i agresivni (brzorastući tok). Folikularni limfom (FL) najčešći je indolentni oblik NHL, dok je difuzni krupnoćelijski B‑limfom (diffuse large b-cell lymphoma, DLBCL) najčešći agresivni oblik. Prikaz bolesnika. U radu je prikazana bolesnica stara 35 godina sa NHL, DLBCL, lokalizovanim u grliću materice, kojoj je nakon biopsije grlića materice, patohistološki dijagnostikovana displazija lakog stepena (CIN1/L-SIL) pokrovnog epitela grlića materice, a zatim dokazana infekcija humanim papiloma virusom (HPV), podtipovima 16 i 31. Dijagnoza DLBCL je patohistološki potvrđena na koničnom isečku vaginalne porcije uterusa, nakon čega je bolesnica lečena sa osam ciklusa hemioterapije po protokolu RCHOP. Zaključak. Koegzistencija CIN1/L-SIL i NHL je slučajna. Usled toga, može se prevideti prateći cervikalni limfom, koji je uobičajeno lokalizovan subepitelno, ukoliko se biopsije ne uzimaju na adekvatan način i ukoliko se ne uradi HPV serotipizacija uzorka biopsije.

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Limfom grlića materice – retka klinička prezentacija

Sažetak

Reference