Povezanost između visoko osetljivog C-reaktivnog proteina i krvnog pritiska nezavisna od životnog doba kod sredovečnih osoba
Sažetak
Uvod/Cilj. Sve više dokaza ukazuje na to da je visoko osetljivi C-reaktivni protein (high-sensitivity C-reactive protein ˗ hs-CRP) pouzdan biomarker kod bolesnika sa hipertenzijom. Dok je veza između hipertenzije i životnog doba dobro utvrđena, veza između hs-CRP i životnog doba još uvek nije dovoljno jasna. Cilj rada bio je da se utvrdi povezanost između hs-CRP i životnog doba, indeksa telesne mase (ITM) i krvnog pritiska kod osoba srednjih godina. Metode. Ova studija preseka sprovedena je u Šangaju, u Kini i uključila je podatke o 1 677 zdravih muških ispitanika, od 18 do 50 godina, i 1 127 zdravih ženskih ispitanika, od 19 do 49 godina, koji su prikupljeni tokom redovnih zdravstvenih pregleda. Beleženi su hs-CRP, ITM, sistolni krvni pritisak (SKP), i dijastolni krvni pritisak (DKP). Rezultati. Ispitanici su prvo bili podeljeni prema životnom dobu u četiri grupe, kvartilno, u kojima je utvrđen porast BMI, SKP i DKP, ali ne i hs-CRP. Zatim su ispitanici podeljeni kvartilno u četiri grupe, prema hs-CRP u kojima je utvrđen porast vrednosti BMI, SKP i DKP, ali ne i starosti. Na kraju, korišćenjem Pearson-ove korelacije, nađena je pozitivna korelacija između hs-CRP, ITM, SKP i DKP, ali ne i korelacija između životnog doba i hs-CRP. Zaključak. Životno doba je verovatno pridruženi faktor, jer je u korelaciji sa SKP, DKP i ITM, ali nije u direktnoj korelaciji sa hs-CRP.
Reference
Hansson GK, Robertson AK, Söderberg-Nauclér C. Inflammation and atherosclerosis. Annu Rev Pathol 2006; 1: 297–329.
Windgassen EB, Funtowicz L, Lunsford TN, Harris LA, Mulvagh SL. C-reactive protein and high-sensitivity C-reactive protein: an update for clinicians. Postgrad Med 2011; 123(1): 114–9.
Song IU, Cho HJ, Kim JS, Park IS, Lee KS. Serum hs-CRP levels are increased in de Novo Parkinson's disease independently from age of onset. Eur Neurol 2014; 72(5–6): 285–9.
Petrović M, Dragović T, Petrović S, Obrenčević K, Rančić N, Djuraši-nović T, et al. Effect of Vitamin D on proteinuria, lipid status, glycoregulation and C-reactive protein in patients with type-2 diabetes mellitus. Vojnosanit Pregl 2020; 77(6): 582–9.
Marjanović V, Budić I, Slavković A, Radlović V, Simić D. C-reactive protein and procalcitonin as a predictive factor on ap-pearance of postoperative complications after open appendec-tomy in children. Srp Arh Celok Lek 2017; 145(5–6): 265–70.
Knežević-Rangelov S, Janković SM. Accuracy of serum procalci-tonin, C-reactive protein, and soluble CD14 subtype levels in diagnosis of sepsis in children. Vojnosanit Pregl 2021; 78(3): 343–6.
Ghobadi H, Fouladi N, Beukaghazadeh K, Ansarin K. Association of High Sensitive CRP Level and COPD Assessment Test Scores with Clinically Important Predictive Outcomes in Sta-ble COPD Patients. Tanaffos 2015; 14(1): 34–41.
Boshku AA, Panova DI, Ivanovska BZ. Association of vascular and inflammatory markers with metabolic disorders in women with polycystic ovary syndrome. Vojnosanit Pregl 2019; 76(7): 703–9.
Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2010; 56(25): e50–103.
Demirbaş A, Kurtipek GS, Tunçez A, Akyürek F, Demirbaş GU. The role of cystatin-C and fetuin-A in the determination of early atherosclerotic risk in psoriasis patients. Dermatol Ther 2020; 33(6): e13898.
Milan-Mattos JC, Anibal FF, Perseguini NM, Minatel V, Rehder-Santos P, Castro CA, et al. Effects of natural aging and gender on pro-inflammatory markers. Braz J Med Biol Res 2019; 52(9): e8392.
Kim DJ, Choi SH, Kim SH, Chung SS, Ahn CW, Cha BS, et al. High sensitive C-reactive protein and carotid intima media thickness in Korean population. Korean Diabetes J 2003; 27(1): 49–62. (Korean)
Rondó PH, Pereira JA, Lemos JO. High sensitivity C-reactive protein concentrations, birthweight and cardiovascular risk markers in Brazilian children. Eur J Clin Nutr 2013; 67(6): 664–9.
Coulon J, Willems D, Dorchy H. Increase in C-reactive protein plasma levels during diabetes in infants and young adults. Presse Med 2005; 34(2 Pt 1): 89–93. (French)
Firouzjahi A, Monadi M, Karimpoor F, Heidari B, Dankoob Y, Hajian-Tilaki K, et al. Serum C-reactive protein level and distribution in chronic obstructive pulmonary disease versus healthy controls: a case-control study from Iran. Inflammation 2013; 36(5): 1122–8.
Hermida J, Lopez FL, Montes R, Matsushita K, Astor BC, Alonso A. Usefulness of high-sensitivity C-reactive protein to predict mortality in patients with atrial fibrillation (from the Athero-sclerosis Risk In Communities [ARIC] Study). Am J Cardiol 2012; 109(1): 95–9.
Barnes EV, Narain S, Naranjo A, Shuster J, Segal MS, Sobel ES, et al. High sensitivity C-reactive protein in systemic lupus ery-thematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk. Lupus 2005; 14(8): 576–82.
Liu H, Zhang Y, Gao Y, Zhang Z. Elevated levels of Hs-CRP and IL-6 after delivery are associated with depression during the 6 months post partum. Psychiatry Res 2016; 243: 43–8.
Feldman M, Sbong S. Is CRP, like ESR, Age and Gender de-pendent? Rheumatology (Sunnyvale) 2014; 4(2): 134. doi: 10.4172/2161-1149.1000134
Allam MH, Said AF, El Samie Omran AA, Abd El-Reheim DM, Kasem AH. High sensitivity C-reactive protein: its correlation with sputum cell counts in bronchial asthma. Respir Med 2009; 103(12): 1878–84.
Lee J, Yoon K, Ryu S, Chang Y, Kim HR. High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men. PLoS One 2017; 12(2): e0172666. Erratum in: PLoS One 2018; 13(10): e0206834.
Lapice E, Maione S, Patti L, Cipriano P, Rivellese AA, Riccardi G, et al. Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people. Diabetes Care 2009; 32(9): 1734–6.
Im JA, Kim SH, Lee JW, Shim JY, Lee HR, Lee DC. Association between hypoadiponectinemia and cardiovascular risk factors in nonobese healthy adults. Metabolism 2006; 55(11): 1546–50.
De BK, Smith LG, Owen WE, Roberts WL. Performance characteristics of an automated high-sensitivity C-reactive protein assay on the Dimension RXL analyzer. Clin Chim Acta 2002; 323(1–2): 151–5.
Hornung RW, Reed LD. Estimation of Average Concentration in the Presence of Nondetectable Values. Appl Occup Envi-ron Hyg 1990; 5(1): 46–51.
Jayedi A, Rahimi K, Bautista LE, Nazarzadeh M, Zargar MS, Shab-Bidar S. Inflammation markers and risk of developing hypertension: a meta-analysis of cohort studies. Heart 2019; 105(9): 686–92.
Clearfield MB. C-reactive protein: a new risk assessment tool for cardiovascular disease. J Am Osteopath Assoc 2005; 105(9): 409–16.
Wang Z, Wang X, Chen Z, Zhang L, Zhu M. Distribution of High-Sensitivity C-Reactive Protein and Its Relationship with Other Cardiovascular Risk Factors in the Middle-Aged Chinese Population. Int J Environ Res Public Health 2016; 13(9): 872.
Wang Z, Chen Z, Zhang L, Wang X, Hao G, Zhang Z, et al. Status of Hypertension in China: Results From the China Hypertension Survey, 2012-2015. Circulation 2018; 137(22): 2344–56.
Zhou B, Wu Y, Yang J, Li Y, Zhang H, Zhao L. Overweight is an independent risk factor for cardiovascular disease in Chinese populations. Obes Rev 2002; 3(3): 147–56.
Thomas GN, Ho SY, Lam KS, Janus ED, Hedley AJ, Lam TH, et al. Impact of obesity and body fat distribution on cardiovascular risk factors in Hong Kong Chinese. Obes Res 2004; 12(11): 1805–13.
Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM, Ridker PM. C-reactive protein and the risk of developing hypertension. JAMA 2003; 290(22): 2945–51.
Decker ML, Gotta V, Wellmann S, Ritz N. Cytokine profiling in healthy children shows association of age with cytokine concentrations. Sci Rep 2017; 7(1): Article No. 17842.
Lin Y, Kim J, Metter EJ, Nguyen H, Truong T, Lustig A, et al. Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine recep-tors. Immun Ageing 2016; 13: 24.
Bernstein ED, Murasko DM. Effect of age on cytokine produc-tion in humans. Age (Omaha) 1998; 21(4): 137–51.