Kvalitet života nakon maksilektomije i protetske rehabilitacije: pilot studija
Sažetak
Uvod/Cilj. Iako je radikalno hirurško lečenje metod izbora u lečenju tumora gornje vilice i maksilarnih sinusa, ono može dovesti do oralnih disfunkcija, socijalne izolacije, kao i emocionalnog i psihološkog stresa, što značajno utiče na kvalitet života (KŽ) bolesnika. Cilj rada bio je da se ispita KŽ povezan sa zdravljem bolesnika kod kojih je posle maksilektomije primenjena opturator proteza (OP), u odnosu na njihove demografske i kliničke karakteristike. Metode. Istraživanjem su obuhvaćena 32 bolesnika, prosečne starosti 63,6 godina. Merenje KŽ bolesnika posle maksilektomije i protetske rehabilitacije vršeno je korišćenjem European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) upitnika i posebnim modulom upitnika za tumore glave i vrata – EORTC QLQ – Head and Neck Cancer Module (QLQ-H&N43). Rezultati. Poremećaji funkcionisanja i simptomi bili su značajno izraženiji kod žena, mlađih bolesnika i samaca (p < 0,05). Nakon rehabilitacije definitivnom opturator protezom (OP), bolesnici su imali manje problema i simptoma u odnosu na bolesnike sa hirurškom ili interim OP (p < 0,05). Bolesnici sa parcijalnim OP imali su bolju percepciju funkcije u odnosu na bolesnike sa totalnim protezama (p < 0,05). Zračeni bolesnici imali su izraženiji umor, gubitak apetita, bol u ustima, suva usta i lepljivu pljuvačku, probleme sa čulima i kožom, u poređenju sa nezračenim bolesnicima (p < 0,05). Zaključak. Rezultati ovog istraživanja ukazuju na to da pol, starost, bračni status, karakteristike OP i radioterapija imaju značajan uticaj na KŽ bolesnika nakon maksilektomije.
Reference
1. World Health Organization. Global Cancer Observatory. Paris, France: International Agency for Research on Cancer. Available from: https://gco.iarc.fr/ [accessed 2021 October 6].
2. Institute of Public Health of Serbia Dr. Milan Jovanovic- Batut. Center for prevention and control of noncommunicable diseases. Cancer incidence and mortality in central Serbia 2015. Belgrade: Cancer Registry of Central Serbia 2015.
3. Valdez JA, Brennan MT. Impact of Oral Cancer on Quality of Life. Dent Clin North Am 2018; 62(1): 143‒54.
4. Dholam KP, Dugad JA, Sadashiva KM. Impact of oral rehabilitation on patients with head and neck cancer: A study using the Liverpool Oral Rehabilitation Questionnaire and the Oral Health Impact Profile-14. J Prosthet Dent 2017; 117(4): 559‒62.
5. Keyf F. Obturator prostheses for hemimaxillectomy patients. J Oral Rehabil 2001; 28(9): 821‒9.
6. Seignemartin CP, Miranda ME, Luz JG, Teixeira RG. Understandability of Speech Predicts Quality of Life Among Maxillectomy Patients Restored With Obturator Prosthesis. J Oral Maxillofac Surg 2015; 73(10): 2040‒8.
7. Dalkiz M, Dalkiz AS. The Effect of Immediate Obturator Reconstruction after Radical Maxillary Resections on Speech and Other Functions. Dent J (Basel) 2018; 6(3): 22.
8. Depprich R, Naujoks C, Lind D, Ommerborn M, Meyer U, Kübler NR, et al. Evaluation of the quality of life of patients with maxillofacial defects after prosthodontic therapy with obturator prostheses. Int J Oral Maxillofac Surg 2011; 40(1): 71–9.
9. Ali MM, Khalifa N, Alhajj MN. Quality of life and problems associated with obturators of patients with maxillectomies. Head Face Med 2018; 14(1): 2.
10. Chigurupati R, Aloor N, Salas R, Schmidt BL. Quality of life after maxillectomy and prosthetic obturator rehabilitation. J Oral Maxillofac Surg 2013; 71(8): 1471‒8.
11. Chen C, Ren WH, Huang RZ, Gao L, Hu ZP, Zhang LM, et al. Quality of Life in Patients After Maxillectomy and Placement of Prosthetic Obturator. Int J Prosthodont 2016; 29(4): 363‒8.
12. Artopoulou II, Karademas EC, Papadogeorgakis N, Papathanasiou I, Polyzois G. Effects of sociodemographic, treatment variables, and medical characteristics on quality of life of patients with maxillectomy restored with obturator prostheses. J Prosthet Dent 2017; 118(6): 783‒9. e4.
13. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute 1993; 85(5): 365–76.
14. Bjordal K, de Graeff A, Fayers PM, Hammerlid E, van Pottelsberghe C, Curran D, et al. A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients. EORTC quality of life group. Eur J Cancer 2000; 36(14): 1796–807.
15. Trivic S, Trivic A, Singer S, Milovanovic J, Stankovic P, Mikic A, et al. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck Module, updated version: Preliminary psychometric data from Serbian laryngectomized patients. Head Neck 2016; 38(1): 916‒24.
16. Singer S, Amdal CD, Hammerlid E, Tomaszewska IM, Castro Silva J, Mehanna H, et al. EORTC Quality of Life and the EORTC Head and Neck Cancer Groups. International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV. Head Neck 2019; 41(6): 1725‒37.
17. Fayers PM, Aaronson NK, Bjordal K, Groenvold M, Curran D, Bottomley A. EORTC QLQ-C30 Scoring Manual (3rd Edition). Brussels: European Organisation for Research and Treatment of Cancer; 2001.
18. Di Maio M, Gallo C, Leighl NB, Piccirillo MC, Daniele G, Nuzzo F, et al. Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials. J Clin Oncol 2015; 33(8): 910‒5.
19. Wu YS, Lin PY, Chien CY, Fang FM, Chiu NM, Hung CF, et al. Anxiety and depression in patients with head and neck cancer: 6-month follow-up study. Neuropsychiatr Dis Treat 2016; 12: 1029‒36.
20. Maciejewski O, Smeets R, Gerhards F, Kolk A, Kloss F, Stein JM, et al. Gender specific quality of life in patients with oral squamous cell carcinomas. Head Face Med 2010; 6: 21.
21. Milovanović J, Andrejić D, Jotić A, Đukić V, Tošković O, Savić-Vujović K, et al. The impact of socioeconomic factors on quality of life and functional impairment in patients treated for oropharyngeal carcinoma. Vojnosanit Pregl 2019; 76(6): 598‒606.
22. López-Jornet P, Camacho-Alonso F, López-Tortosa J, Palazon Tovar T, Rodríguez-Gonzales MA. Assessing quality of life in patients with head and neck cancer in Spain by means of EORTC QLQ-C30 and QLQ-H&N35. J Craniomaxillofac Surg 2012; 40(7): 614‒20.
23. Kumar P, Alvi HA, Rao J, Singh BP, Jurel SK, Kumar L, et al. Assessment of the quality of life in maxillectomy patients: A longitudinal study. J Adv Prosthodont 2013; 5(1): 29‒35.
24. Laraway DC, Lakshmiah R, Lowe D, Roe B, Rogers SN. Quality of life in older people with oral cancer. Br J Oral Maxillofac Surg 2012; 50(8): 715‒20.
25. Dholam K, Chouksey G, Dugad J. Impact of Oral Rehabilitation on Patients with Head and Neck Cancer: Study of 100 Patients with Liverpool Oral Rehabilitation Questionnaire and the Oral Health Impact Profile. Indian J Otolaryngol Head Neck Surg 2020; 72(3): 308‒12.
26. Vero N, Mishra N, Singh BP, Singh K, Jurel SK, Kumar V. Assessment of swallowing and masticatory performance in obturator wearers: a clinical study. J Adv Prosthodont 2015; 7(1): 8‒14.
27. Dholam KP, Bachher G, Gurav SV. Changes in the quality of life and acoustic speech parameters of patients in various stages of prosthetic rehabilitation with an obturator after maxillectomy. J Prosthet Dent 2020; 123(2): 355‒63.
28. Shuman AG, Duffy SA, Ronis DL, Garetz SL, McLean SA, Fowler KE, et al. Predictors of poor sleep quality among head and neck cancer patients. Laryngoscope 2010; 120(6): 1166‒72.
29. Şirin G, Şirin S. Functional constipation as a neglected condition in laryngectomized patients. Turk J Gastroenterol 2020; 31(2): 120‒7.
30. do Nascimento Santos Lima E, Ferreira IB, Lajolo PP, Paiva CE, de Paiva Maia YC. Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study. Health Qual Life Outcomes 2020; 18(1): 307.
31. Tesic M, Cankovic M, Jevtic M, Stevanovic D. Validation of the oral health impact profile - 14 in patients with head and neck cancer. Med Oral Patol Oral Cir Bucal 2020; 25(6): e739‒44.