Korelacija između nivoa serumskog kvantitativnog HBsAg i HBV DNK kod bolesnika sa hroničnim hepatitisom B

  • Maria Pete University Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia
  • Maja Ružić University Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia
  • Nadica Kovačević University Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia
  • Vedrana Petrić University Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia
  • Ivana Milošević University Clinical Center of Serbia, Clinic for Infectious and Tropical Diseases, Belgrade, Serbia
  • Tomislav Preveden University Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia
DOI: https://doi.org/10.2298/VSP220528086P
Ključne reči: biomarkeri, lečenje lekovima, hepatitis b, hepatitis b, e antigeni, hepatitis b, površinski antigeni, hepatitis b, virus

Sažetak


Uvod/Cilj. Kvantitativni površinski antigen hepatitis B (qHBsAg) virusa je poslednjih nekoliko godina sve aktuelniji u dijagnostičkim i terapijskim protokolima hronične infekcije hepatitis B virusom (HBV). Prema mnogobrojnim studijama, predložen je kao surogat marker za cirkularnu kovalentno vezanu DNK (cccDNK). Cilj rada bio je da se ispita korelacija između qHBsAg i viremije HBV DNK kod nelečenih bolesnika. Metode. Istraživanjem su obuhvaćena 112 nelečena bolesnika sa dijagnozom hronične infekcije HBV. Zabeleženi su demografski i ostali podaci svih bolesnika iz medicinskih kartona, kao i rezultati rutinskih laboratorijskih analiza uz određivanje qHBsAg i viremije HBV DNK. Rezultati. Prosečna starost bolesnika obuhvaćenih istraživanjem bila je 48,27 ± 15,14 godina, a muški pol je bio zastupljeniji (58%). Nivoi qHBsAg su bili u pozitivnoj korelaciji visokog inteziteta sa viremijom HBV DNK. Koncentracija qHBsAg, viremija HBV DNK, kao i koncentracije alanin aminotransferaze i aspartat aminotransferaze pokazale su statistički značajno više vrednosti kod HBV e antigen (HbeAg)-pozitivnih nego kod HBeAg-negativnih bolesnika. Zaključak. Ovim istraživanjem je pokazano da je qHBsAg u pozitivnoj korelaciji visokog inteziteta sa viremijom HBV DNK. Upotreba qHBsAg je bitna za određivanje faze hronične HBV infekcije, procenu uspeha i dužine trajanja terapije, kao i za bezbedniji prekid antivirusne terapije sa manjim rizikom od relapsa bolesti.

Biografija autora

Maria Pete, University Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia

Lekar opšte prakse

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Objavljeno
2023/08/01
Broj časopisa
Vol. 80 Br. 07 (2023): Vojnosanitetski pregled
Rubrika
Originalni članak