Value of real-time tissue elastography diffusion quantitative analysis combined with tumor markers for differential diagnosis of benign and malignant breast nodules

Ling Zhu; Lina  Mei; Xuekui  Pan

doi:10.2298/VSP230130077Z

Ling Zhu Huzhou Maternal and Child Health Hospital, *Department of Ultrasound, Zhejiang Province, China
Lina Mei Huzhou Maternal and Child Health Hospital, †Department of Internal Medicine, Huzhou, Zhejiang Province, China
Xuekui Pan Huzhou Maternal and Child Health Hospital, *Department of Ultrasound, Huzhou, Zhejiang Province, China

DOI: https://doi.org/10.2298/VSP230130077Z

Ključne reči: dojka, neoplazme;, tumorski markeri;, dijagnoza, diferencijalna;, elasticitet, tehnike snimanja;, osetljivost i specifičnost.

Sažetak

Uvod/Cilj. Za razlikovanje benignih i malignih nodusa (čvorića) dojke (ND) često se kombinuju serumski tumorski markeri (TM) i analize snimaka nodusnih promena, mada ograničenja još uvek postoje. Cilj rada bio je da se utvrdi korisnost elastografije mekih tkiva u realnom vremenu (EMTRV) sa kvantitativnom analizom u kombinaciji sa serumskim TM za diferencijalnu dijagnozu benignih i malignih ND. Metode. Ukupno 149 žena sa ND bilo je uključeno u ovu studiju. Bolesnice su podeljene na grupu sa benignim ND (n = 87) i grupu sa malignim ND (n = 62). Sve bolesnice su bile ispitane primenom EMTRV sa kvantitativnom analizom. Iz venske krvi, određivani su nivoi TM: karcinoembrionskog antigena-CAE, karcinomskog antigena (cancer antigen – CA) 153 i CA 199. Za diferencijalnu dijagnozu benignih i malignih ND, analizirane su vrednosti parametara EMTRV sa kvantitativnom analizom, TM i njihove kombinacije, korišćenjem receiver operating characteristic-ROC krive. Rezultati. Među navedenim pokazateljima, najveću diferencijalnu vrednost imala je area ratio of the blue region (AREA%) sa površinom ispod krive (area under the curve – AUC) od 0,916 [95% confidence interval (CI): 0,812–0,967], dok su senzitivnost i specifičnost iznosile 88,90% i 86,79%, redom (p < 0,05). U poređenju sa EMTRV sa kvantitativnom analizom ili samo sa TM, njihova kombinacija je pokazala najvišu vrednost za razlikovanje benignih i malignih ND, sa AUC 0,957 (95% CI: 0,834–0,982), dok su senzitivnost i specifičnost iznosile 95,50% i 94,33%, redom. Zaključak. EMTRV sa kvantitativnom analizom u kombinaciji sa TM ima veliku vrednost za razlikovanje benignih i malignih ND.

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Vrednost elastografije mekih tkiva u realnom vremenu sa kvantitativnom analizom u kombinaciji sa tumorskim markerima za diferencijalnu dijagnozu benignih i malignih nodusa dojke

Sažetak

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