Slabo diferentovani cervikalni adenokarcinom sa preovlađujućom formom horiokarcinoma

  • Branka S Nikolić Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia
  • Aleksandar Ćurković Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia
  • Svetlana Dragojevic Dikic G/O Clinic Narodni front, Belgrade, Serbia University of Belgrade, Medical Faculty
  • Ana Mitrović Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia
  • Igor Kuzmanović Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia
  • Aleksandra Arandjelović Clinical Hospital Center “Zvezdara”, Belgrade, Serbia
  • Goran Stanković Faculty of Medicine, University of Belgrade, Belgrade, Serbia Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia
DOI: https://doi.org/10.2298/4588
Ključne reči: uterine cervical neoplasms||, ||grlić materice, neoplazme, adenocarcinoma||, ||adenokarcinom, choriocarcinoma||, ||horiokarcinom, comorbidity||, ||komorbiditet, histology||, ||histologija, gynecologic surgical procedures||, ||hirurgija, ginekološka, procedure,

Sažetak


Uvod. Gestacijska trofoblastna neoplazma (GTN), horiokarcinom zajedno sa primarnim cervikalnim adenokarcinomom retko se javlja i nije ga lako dijagnostikovati. Horiokarcinom je maligni oblik GTN i izlečiv je ako se ne pojave rane metastaze koje se brzo šire. Prikaz bolesnika. Kod bolesnice, stare 48 godina, sa primarnim karcinomom grlića materice i istovemeno horiokarcinomom urađena je radikalna histerektomija zbog potvrđenog karcinoma cerviksa (Dg: Carcinoma porto vaginalis uteri FIGO st I B1). Histološkim pregledom potvrđen je horiokarcinom cerviksa sa rasprostranjenom vaskularnom invazijom i apoptozom, ali je definitivna dijagnoza GTN – choriocarcinoma potvrđena nakon imunohistohemijskog pregleda. Preoperatvne vrednosti humanog horiogonadotropina (beta hCG) u serumu nisu bile poznate. Pre operacije bolesnica nije imala simptome slične onim u trudnoći. Prvi beta hCG kontrolisan je dva meseca nakon operacije i bio je negativan. U skladu sa konačnom dijagnozom, preporuka konzilijuma za maligne bolesti bila je hemioterapija prema protokolu za GTN visokog rizika uz zračnu terapiju za adenokarcinom, kao i redovne kontrole serumskog hCG. Zaključak. Pravovremena i tačna dijagnoza nemetastatskog horiokarcinoma negastacijskog porekla zajedno sa karcinomom cerviksa je izlečiva i može da ima dobar ishod

Biografije autora

Branka S Nikolić, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia

Head of dept of Gynecology

Reviewer: Central European J of Medicine

Cancer Therapy

Journal of Case Reports

International J of Gyn Cancer

Srpski arhiv

Vojnosanitetski pregled

Aleksandar Ćurković, Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia

Preoperative care Department

Subspecialist of Perinatology

Svetlana Dragojevic Dikic, G/O Clinic Narodni front, Belgrade, Serbia University of Belgrade, Medical Faculty

Head of Puerperium ward

Gynecological Endocrinology

Igor Kuzmanović, Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia
Head of the Pathology Department
Aleksandra Arandjelović, Clinical Hospital Center “Zvezdara”, Belgrade, Serbia
Cardiologist
Goran Stanković, Faculty of Medicine, University of Belgrade, Belgrade, Serbia Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia
Cardiologist

Reference

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Objavljeno
2015/11/02
Broj časopisa
Vol. 72 Br. 7 (2015)
Rubrika
Prikaz bolesnika