Portal vein thrombosis in patients with liver cirrhosis

Željka Savić; Dimitrije Damjanov; Olgica Latinović Bošnjak; Nebojša Janjić; Božidar Dejanović; Žarko Krnetić; Vladimir Vračarić

doi:10.2298/VSP240116029S

Željka Savić *University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; †University Clinical Center of Vojvodina, Clinic for Gastroenterology and Hepatology, Novi Sad, Serbia https://orcid.org/0000-0003-0720-4738
Dimitrije Damjanov *University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; †University Clinical Center of Vojvodina, Clinic for Gastroenterology and Hepatology, Novi Sad, Serbia
Olgica Latinović Bošnjak University Clinical Center of Vojvodina, Clinic for Gastroenterology and Hepatology, Novi Sad, Serbia
Nebojša Janjić *University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; †University Clinical Center of Vojvodina, Clinic for Gastroenterology and Hepatology, Novi Sad, Serbia
Božidar Dejanović *University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; †University Clinical Center of Vojvodina, Clinic for Gastroenterology and Hepatology, Novi Sad, Serbia
Žarko Krnetić University Clinical Center of Vojvodina, Clinic for Gastroenterology and Hepatology, Novi Sad, Serbia
Vladimir Vračarić University Clinical Center of Vojvodina, Clinic for Gastroenterology and Hepatology, Novi Sad, Serbia

DOI: https://doi.org/10.2298/VSP240116029S

Ključne reči: jednjak, variksi;, hipertenzija, portalna;, jetra, ciroza;, v.portae;, tromboza.

Sažetak

Uvod/Cilj. Tromboza vene porte (TVP) kod bolesnika sa cirozom jetre (CJ) ima prevalenciju od 0,6–26%. Najčešće se TVP otkriva slučajno, u sklopu evaluacije CJ, ili u sklopu akutne dekompenzacije CJ zbog portne hipertenzije. Cilj rada bio je da se ustanovi zastupljenost TVP kod bolesnika sa CJ u odnosu na težinu bolesti i pojedine elemente portne hipertenzije. Metode. Retrospektivnim istraživanjem obuhvaćeno je 326 bolesnika lečenih zbog dekompenzacije CJ. Bolesnicima su rađene standardne laboratorijske analize, ultrasonografija abdomena i/ili kompjuterizovana tomografija abdomena i ezofagogastroduodenoskopija. Rezultati. Dijametar vene porte (VP) razlikovao se kod bolesnika bez variksa jednjaka (12,2 mm) i onih koji su imali velike varikse (13,6 mm), p = 0,026. TVP je ustanovljena kod 6,1% bolesnika sa CJ. Bolesnici su klasifikovani u skladu sa Child-Pugh sistemom bodovanja, kojim se težina oboljenja jetre izražava kategorijama A, B i C. TVP je bila prisutna kod 3.0% bolesnika iz kategorije C, kod 12,0% bolesnika iz kategorije B, a nije bila prisutna ni kod jednog bolesnika iz kategorije A (p = 0,005). TVP je bila prisutna kod 4,4% bolesnika sa malim variksima i kod 16,7% bolesnika sa velikim variksima (p < 0,001). Nije bilo razlike u prisustvu TVP između grupa bolesnika sa i bez variksnog krvarenja, kao ni između grupa sa različitim stepenom ascita. Kod 29,4% bolesnika nastupio je smrtni ishod, ali nije bilo razlike između bolesnika sa i bez TVP. Zaključak. TVP je prisutna kod težih stadijuma CJ i pretežno kod bolesnika sa velikim variksima jednjaka. Nije ustanovljena veća prevalencija TVP povezana sa pojavom variksnog krvarenja ili smrtnim ishodom bolesnika sa CJ.

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Tromboza vene porte kod bolesnika sa cirozom jetre

Sažetak

Reference