Lečenje aneurizmi splanhničnih arterija – rezultati i iskustva jednog centra

  • Ognjen Kostić University Clinical Center of Serbia, Clinic for Vascular and Endovascular Surgery, Belgrade, Serbia
  • Stefan Dučić University Clinical Center of Serbia, Clinic for Vascular and Endovascular Surgery, Belgrade, Serbia
  • David Matejević University Clinical Center of Serbia, Clinic for Vascular and Endovascular Surgery, Belgrade, Serbia
  • Andrija Roganović University Clinical Center of Serbia, Clinic for Vascular and Endovascular Surgery, Belgrade, Serbia
  • Lazar Davidović University Clinical Center of Serbia, Clinic for Vascular and Endovascular Surgery, Belgrade, Serbia; University of Belgrade, Faculty of Medicine, Belgrade, Serbia
Ključne reči: aneurizma;, arterije;, endovaskularne procedure;, srbija;, lečenje, ishod;, hirurgija, vaskularna, procedure.

Sažetak


Uvod/Cilj. Aneurizme visceralnih arterija (visceral artery aneurysms – VAAs) su retka, ali po život potencijalno opasna stanja. Sa porastom dostupnih dijagnostičkih i terapijskih mogućnosti, raste potreba za određivanjem optimalnog terapijskog pristupa–endovaskularna (EV) rekonstrukcija vs. otvorena hirurška (open surgery – OS) rekonstrukcija. Cilj rada bio je da se analiziraju ishodi lečenja obolelih od VAA u jednom centru i uporedi efikasnost EV i OS pristupa. Metode. Istraživanjem je obuhvaćeno 27 OS (OS grupa) ili EV (EV grupa) intervencija za VAA, sprovedenih u našoj ustanovi od januara 2010. do novembra 2023. godine, kod 27 bolesnika, 13 muškog i 14 ženskog pola prosečne starosti 57 ± 13 godina.  Odluke o lečenju donosio je multidisciplinarni tim, koji su činili vaskularni hirurg, anesteziolog i interventni radiolog. Rezultati. Od ukupno 27 bolesnika, 9 je zbrinuto kao hitni slučajevi, od kojih je 6 imalo rupturu aneurizme. Najčešća je bila aneurizma slezinske arterije, 50,0% svih VAAs. Trinaest bolesnika podvrgnuto je EV rekonstrukciji, hibridnom pristupu 1 bolesnik, a OS rekonstrukciji 13 bolesnika. Tehnički uspeh bio je 24/27 ili 88,9%. Embolizacijom spiralama lečeno je 11 bolesnika, dok su 2 bolesnika lečena ugradnjom pokrivenog stenta. U grupi bolesnika lečenih EV putem nije bilo smrntih ishoda. Kod 14 bolesnika urađeno je OS hirurško lečenje sa 9 VAA resekcija i arterijskih rekonstrukcija (7 Dacron graftom, 1 politetrafluoroetilen graftom i 1 autovenskim graftom), uz 2 splenektomije i 3 isključenja aneurizme. Usled jakog krvarenja, 2 bolesnika su preminula tokom operacije, a jedan posle zahvata zbog crevnih ishemijskih komplikacija. Prosečno trajanje hospitalizacije posle OS ili EV procedure iznosilo je 7,43 i 4,92 dana, redom. Zaključak. Lečenje EV pristupom je bezbedno, sa manje invazivnosti i kraćim boravkom u bolnici i pogodno je za elektivne i hitne slučajeve, kada je to tehnički izvodljivo. Primena OS pristupa ostaje pouzdana mogućnost u centrima sa velikim brojem operacija, posebno za složene slučajeve koji nisu pogodni za EV pristup ili kod bolesnika sa niskim rizikom. Odluka o lečenju treba da bude vođena karakteristikama VAA (veličina, simptomi, lokacija, morfologija), komorbiditetima bolesnika i specifičnim kliničkim kontekstom, poput prethodnih abdominalnih operacija.

Reference

Batagini NC, Constantin BD, Kirksey L, Vallentsits Estenssoro AE, Puech Leão P, De Luccia N, et al. Natural history of splanchnic artery aneurysms. Ann Vasc Surg 2021; 73: 290–5. DOI: 10.1016/j.avsg.2020.10.047.

Lynch MJ, Woodford NW. Rupture of a splenic artery aneurysm during pregnancy with maternal and foetal death: a case re-port. Med Sci Law 2008; 48(4): 342–5. DOI: 10.1258/rsmmsl.48.4.342.

Paul M. A large traumatic aneurysm of the hepatic artery. Br J Surg 1951; 39(155): 278–80. DOI: 10.1002/bjs.18003915518.

Davidović LB, Marković MD, Bjelović MM, Cvetković SD. Splanchnic artery aneurysms. Srp Arh Celok Lek 2006; 134(7–8): 283–9. DOI: 10.2298/SARH0608283D. (Serbian)

Popov P, Boskovic S, Sagic D, Radevic B, Ilijevski N, Nenezic D, et al. Treatment of visceral artery aneurysms: retrospective study of 35 cases. Vasa 2007; 36(3): 191–8. DOI: 10.1024/0301-1526.36.3.191.

Ilić N, Banzić I, Šteković J, Končar I, Davidović L, Fatić N. Multi-ple visceral artery aneurysms. Ann Vasc Surg 2015; 29(6): 1318.e7–e10. DOI: 10.1016/j.avsg.2015.02.026.

Miani S, Arpesani A, Giorgetti PL, Rampoldi V, Giordanengo F, Ruberti U. Splanchnic artery aneurysms. J Cardiovasc Surg (Torino) 1993; 34(3): 221–8.

Batagini NC, El Arousy H, Clair DG, Kirksey L. Open versus endovascular treatment of visceral artery aneurysms and pseu-doaneurysms. Ann Vasc Surg 2016; 35: 1–8. DOI: 10.1016/j.avsg.2016.01.035.

Chaer RA, Abularrage CJ, Coleman DM, Eslami MH, Kashyap VS, Rockman C, et al. The Society for Vascular Surgery clinical practice guidelines on the management of visceral aneurysms. J Vasc Surg 2020; 72(Suppl 1): 3S–39S. DOI: 10.1016/j.jvs.2020.01.039.

Carr SC, Mahvi DM, Hoch JR, Archer CW, Turnipseed WD. Vis-ceral artery aneurysm rupture. J Vasc Surg 2001; 33(4): 806–11. DOI: 10.1067/mva.2001.112320.

Barrionuevo P, Malas MB, Nejim B, Haddad A, Morrow A, Ponce O, et al. A systematic review and meta-analysis of the man-agement of visceral artery aneurysms. J Vasc Surg 2019; 70(5): 1694–9. DOI: 10.1016/j.jvs.2019.02.024.

Deterling RA Jr. Aneurysm of the visceral arteries. J Cardio-vasc Surg (Torino) 1971; 12(4): 309–22.

Grego FG, Lepidi S, Ragazzi R, Iurilli V, Stramanà R, Deriu GP. Visceral artery aneurysms: a single center experience. Cardio-vasc Surg 2003; 11(1): 19–25. DOI: 10.1016/S0967-2109(02)00121-7.

Hong Z, Chen F, Yang J, Wu Z, Yan Z. Diagnosis and treatment of splanchnic artery aneurysms: a report of 57 cases. Chin Med J 1999; 112(1): 29–33. DOI: 10.5555/cmj.0366-6999.112.01.p29.01.

Jørgensen BA. Visceral artery aneurysms: a review. Dan Med Bull 1985; 32(4): 237–42.

Bedford PD, Lodge B. Aneurysm of the splenic artery. Gut 1960; 1(4): 312–20. DOI: 10.1136/gut.1.4.312.

Mattar SG, Lumsden AB. The management of splenic artery aneurysms: experience with 23 cases. Am J Surg 1995; 169(6): 580–4. DOI: 10.1016/S0002-9610(99)80225-6.

Manenti F, Williams R. Injection studies of the splenic vascula-ture in portal hypertension. Gut 1966; 7(2): 175–80. DOI: 10.1136/gut.7.2.175.

Stanley JC, Fry WJ. Pathogenesis and clinical significance of splenic artery aneurysms. Surgery 1974; 76(6): 898–909.

Stanley JC, Gewertz BL, Bove EL, Sottiurai V, Fry WJ. Arterial fibrodysplasia: histopathologic character and current etiologic concepts. Arch Surg 1975; 110(5): 561–6. DOI: 10.1001/archsurg.1975.01360110107018.

Boijsen E, Efsing HO. Aneurysm of the splenic artery. Acta Ra-diol Diagn (Stockh) 1969; 8(1): 29–41. DOI: 10.1177/028418516900800105.

Feist JH, Gajaraj A. Extra and intrasplenic artery aneurysms in portal hypertension. Radiology 1977; 125(2): 331–4. DOI: 10.1148/125.2.331.

Gaglio PJ, Regenstein F, Slakey D, Cheng S, Takiff H, Rinker R, et al. Alpha 1 antitrypsin deficiency and splenic artery aneu-rysm rupture: an association? Am J Gastroenterol 2000; 95(6): 1531–4. DOI: 10.1111/j.1572-0241.2000.02090.x.

Scheinin TM, Vänttinen E. Aneurysms of the splenic artery in portal hypertension. Ann Clin Res 1969; 1(3): 165–8.

Puttini M, Aseni P, Brambilla G, Belli L. Splenic artery aneu-rysms in portal hypertension. J Cardiovasc Surg (Torino) 1982; 23(6): 490–3.

Lee PC, Rhee RY, Gordon RY, Fung JJ, Webster MW. Manage-ment of splenic artery aneurysms: the significance of portal and essential hypertension. J Am Coll Surg 1999; 189(5): 483–90. DOI: 10.1016/S1072-7515(99)00168-4.

Yoon HK, Lindh M, Uher P, Lindblad B, Ivancev K. Stent graft repair of a splenic artery aneurysm. Cardiovasc Intervent Ra-diol 2001; 24(3): 200–3. DOI: 10.1007/PL00021044.

Patel JV, Weston MJ, Kessel DO, Prasad R, Toogood GJ, Robertson I. Hepatic artery pseudoaneurysm after liver transplantation: treatment with percutaneous thrombin injection. Transplanta-tion 2003; 75(10): 1755–7. DOI: 10.1097/01.TP.0000063936.94587.10.

Cowan S, Kahn MB, Bonn J, Becker GJ, Dimuzio P, Leichter R, et al. Superior mesenteric artery pseudoaneurysm successfully treated with a polytetrafluoroethylene covered stent. J Vasc Surg 2002; 35(4): 805–7. DOI: 10.1067/mva.2002.121754.

Shumacker HB Jr, Siderys H. Excisional treatment of aneurysm of the celiac artery. Ann Surg 1958; 148(6): 885–9. DOI: 10.1097/00000658-195812000-00003.

Violago FC, Downs AR. Ruptured atherosclerotic aneurysm of the superior mesenteric artery with celiac axis occlusion. Ann Surg 1971; 174(2): 207–10. DOI: 10.1097/00000658-197108000-00006.

Stanley JC, Frey CF, Miller TA, Lindenauer SM, Child CG 3rd. Major arterial hemorrhage: a complication of pancreatic pseu-docysts and chronic pancreatitis. Arch Surg 1976; 111(4): 435–40. DOI: 10.1001/archsurg.1976.01360220131022.

De Bakey ME, Cooley DA. Successful resection of a mycotic aneurysm of the superior mesenteric artery: case report and review of the literature. Am Surg 1953; 19(2): 202–12.

Koelemay MJ, Geelkerken RH, Kärkkäinen J, Leone N, de Bruin JL, Gombert A, et al. European Society for Vascular Surgery (ESVS) 2025 clinical practice guidelines on the management of diseases of the mesenteric and renal arteries and veins. Eur J Vasc Endovasc Surg 2025; 70(2): 153–218. DOI: 10.1016/j.ejvs.2025.06.010.

Pratesi C, Esposito D, Martini R, Novali C, Zaninelli A, Annese AL, et al. Guidelines on the diagnosis, treatment and man-agement of visceral and renal arteries aneurysms: a joint as-sessment by the Italian Societies of Vascular and Endovascular Surgery (SICVE) and Medical and Interventional Radiology (SIRM). J Cardiovasc Surg (Torino) 2024; 65(1): 49–63. DOI: 10.23736/S0021-9509.23.12809-6.

Stone WM, Abbas MA, Gloviczki P, Fowl RJ, Cherry KJ. Celiac arterial aneurysms: a critical reappraisal of a rare entity. Arch Surg 2002; 137(6): 670–4. DOI: 10.1001/archsurg.137.6.670.

Rebelo A, Ronellenfitsch U, Partsakhashvili J, Kleeff J, John E, Ukkat J. Visceral aneurysms: systematic review and meta anal-ysis of endovascular versus open repair. Angiology 2024; 75(6): 546–55. DOI: 10.1177/00033197231164286.

Fargion AT, Falso R, Speziali S, Biancofiore B, Esposito D, Giaco-melli E, et al. Results of current endovascular treatments for visceral artery aneurysms. J Vasc Surg 2023; 78(2): 387–93. DOI: 10.1016/j.jvs.2023.04.040.

Khairallah MK, Morgan RA, Das R. Technical considerations of endovascular management of true visceral artery aneurysms. CVIR Endovasc 2023; 6(1): 31. DOI: 10.1186/s42155-023-00368-9.

Gong C, Sun MS, Leng R, Ren HL, Zheng K, Wang SX, et al. Endovascular embolization of visceral artery aneurysm: a ret-rospective study. Sci Rep 2023; 13: 6936. DOI: 10.1038/s41598-023-33789-6.

Yanar F, Canbay Torun B, İlhan B, Gok AFK, Azamat İF, Sengun B, et al. Endovascular and surgical management of splenic ar-tery aneurysms. Ulus Travma Acil Cerrahi Derg 2024; 30(1): 38–42. DOI: 10.14744/tjtes.2023.23793.

Objavljeno
2026/04/27
Rubrika
Kratko saopštenje