Cerebralna paraliza kod prevremeno rođene dece

  • Čila Demeši Drljan Institute for Children and Youth Health Care of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
  • Aleksandra Mikov Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
  • Karmela FilipoviĆ Special Hospital for Rheumathic Diseases,Novi Sad, Serbia
  • SneŽana TomaŠeviĆ TodoroviĆ Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
  • Aleksandar KneŽeviĆ Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
  • Rastislava Krasnik Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
Ključne reči: Cerebral palsy||, ||paraliza, cerebralna, risk factors||, ||faktori rizika, infant, premature||, ||nedonošče.,

Sažetak


Uvod/Cilj. Cerebralna paraliza (CP) jedan je od najčešćih uzroka nastanka neuroloških oštećenja u dečjem uzrastu. Prevremen porođaj je značajan faktor rizika od pojave CP. Kliničke posledice mogu biti oštećenje grube motoričke funkcije, intelektualnih sposobnosti, poremećaj vida i epilepsija. Cilj rada bio je da se istraži odnos između gestacijske starosti, oblika CP, funkcionalnih sposobnosti i pridruženih oboljenja. Metode. Uzorak se sastojao od ukupno 206 dece. Iz medicinske dokumentacije dobijeni su podaci o gestacijskoj starosti, kliničkim karakteristikama CP i pridruženim oboljenjima. Klinički tip CP određivan je prema preporuci Surveillance of Cerebral Palsy in Europe (SCPE) i topografski. Grube motoričke funkcije procenjivane su na osnovu istoimenog klasifikacionog sistema Gross Motor Function Classification System (GMFCS). Rezultati. Više od polovine dece sa CP prevremeno su rođena (54,4%). Registrovana je statistički značajna razlika u distribuciji kliničkih tipova CP u odnosu na gestacijsku starost (p < 0,001); kod dece sa spastičnim bilateralnim tipom CP više su zastupljena prevemeno rođena deca. Utvrđena je statistički značajna razlika u funkcionalnoj klasifikaciji na osnovu GMFCS u odnosu na gestacijsku starost (p = 0,049); deca koja su manje gestacijske starosti imaju viši stepen prema GMFCS-u. Najveći procenat dece (70,0%) koja imaju dva ili više pridruženih oboljenja utvrđen je kod izrazito prevremeno rođene dece i ovaj broj opada što je termin bliži normalnom terminu porođaja. Epilepsija je bila češća kod dece sa većom gestacijskom starosti i ova razlika u distribuciji bila je statistički značajna (p = 0,032). Zaključak. Primena antenatalne i postnatalne zaštite preterminski rođene dece trebalo bi da bude značajna komponenta strategije prevencije CP.

 

 

 

Biografije autora

Čila Demeši Drljan, Institute for Children and Youth Health Care of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Docent
Aleksandra Mikov, Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
Profesor
Karmela FilipoviĆ, Special Hospital for Rheumathic Diseases,Novi Sad, Serbia
Asistent
SneŽana TomaŠeviĆ TodoroviĆ, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Docent
Aleksandar KneŽeviĆ, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Asistent
Rastislava Krasnik, Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
Asistent

Reference

Stelmach T, Pisarev H, Talvik T. Ante- and perinatal factors for cerebral palsy: case-control study in Estonia. J Child Neurol 2005; 20(8): 654−60.

Himmelmann K, Hagberg G, Wiklund LM, Eek MN, Uvebrant P. Dyskinetic cerebral palsy: a population-based study of children born between 1991 and 1998. Dev Med Child Neurol 2007; 49(4): 246−51.

Winter S, Autry A, Boyle C, Yeargin-Allsopp M. Trends in the prevalence of cerebral palsy in a population-based study. Pediatrics 2002; 110(6): 1220−5.

Pakula AT, Van Braun NK, Yeargin-Allsopp M. Cerebral palsy: classification and epidemiology. Phys Med Rehabil Clin N Am 2009; 20(3): 425−52.

Serdaroğlu A, Cansu A, Ozkan S, Tezcan S. Prevalence of cerebral palsy in Turkish children between the ages of 2 and 16 years. Dev Med Child Neurol 2006; 48(6): 413−6.

Dolk H, Parkes J, Hill N. Trends in the prevalence of cerebral palsy in Northern Ireland, 1981-1997. Dev Med Child Neurol 2006; 48(6): 406−12.

O'Callaghan ME, MacLennan AH, Gibson CS, McMichael GL, Haan EA, Broadbent JL, et al. Epidemiologic associations with cerebral palsy. Obstet Gynecol 2011; 118(3): 576−82.

Colvin M, McGuire W, Fowlie PW. Neurodevelopmental out-comes after preterm birth. BMJ 2004; 329(7479): 1390−3.

Venkateswaran S, Shevell MI. Comorbidities and clinical deter-minants of outcome in children with spastic quadriplegic cere-bral palsy. Dev Med Child Neurol 2008; 50(3): 216−22.

Bax M, Goldstein M, Rosenbaum P, Leviton A, Paneth N, Dan B, et al. Proposed definition and classification of cerebral palsy, April 2005. Dev Med Child Neurol 2005; 47(8): 571−6.

Palisano RJ, Cameron D, Rosenbaum PL, Walter SD, Russell D. Stability of the Gross Motor Function Classification System. Dev Med Child Neurol 2006; 48(6): 424−8.

Bonellie SR, Currie D, Chalmers J. Comparison of risk factors for cerebral palsy in twins and singletons. Dev Med Child Neurol 2005; 47(9): 587−91.

Thorngren-Jerneck K, Herbst A. Perinatal factors associated with cerebral palsy in children born in Sweden. Obstet Gynecol 2006; 108(6): 1499−505.

Himpens E, van den Broeck C, Oostra A, Calders P, Vanhaesebrouck P. Prevalence, type, distribution, and severity of cerebral palsy in relation to gestational age: a meta-analytic review. Dev Med Child Neurol 2008; 50(5): 334−40.

Hoon AH, Stashinko EE, Nagae LM, Lin DD, Keller J, Bastian A, et al. Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnor-malities in thalamocortical pathways. Dev Med Child Neurol 2009; 51(9): 697−704.

Marret S, Zupan V, Gressens P, Lagercrantz H, Evrard P. Periven-tricular leukomalacia. I. Histological and pathophysiological aspects. Arch Pediatr 1998; 5(5): 525−37.

Sigurdardóttir S, Thórkelsson T, Halldórsdóttir M, Thorarensen O, Vik T. Trends in prevalence and characteristics of cerebral palsy among Icelandic children born 1990 to 2003. Dev Med Child Neurol 2009; 51(5): 356−63.

Andersen GL, Irgens LM, Haagaas I, Skranes JS, Meberg AE, Vik T. Cerebral palsy in Norway: prevalence, subtypes and severity. Eur J Paediatr Neurol 2008; 12(1): 4−13.

Himmelman K. Cerebral Palsy in Western Sweden-Epidemiology and Function. Sweden: The Sahlgrenska Academy at Goteborg University; 2006.

Beckung E, Carlsson G, Carlsdotter S, Uvebrant P. The natural his-tory of gross motor development in children with cerebral palsy aged 1 to 15 years. Dev Med Child Neurol 2007; 49(10): 751−6.

Voorman JM, Dallmeijer AJ, Knol DL, Lankhorst GJ, Becher JG. Prospective longitudinal study of gross motor function in children with cerebral palsy. Arch Phys Med Rehabil 2007; 88(7): 871−6.

Caram LH, Funayama CA, Spina CI, Giuliani Ld, de Pina NJM. Investigation of neurodevelopment delay etiology: re-sources and challenges. Arq Neuropsiquiatr 2006; 64(2B): 466−72.

Pfeifer LI, Silva DB, Funayama CA, Santos JL. Classification of cerebral palsy: association between gender, age, motor type, topography and Gross Motor Function. Arq Neuropsiquiatr 2009; 67(4): 1057−61.

Himmelmann K, Beckung E, Hagberg G, Uvebrant P. Gross and fine motor function and accompanying impairments in cere-bral palsy. Dev Med Child Neurol 2006; 48(6): 417−23.

Howard J, Soo B, Graham KH, Boyd RN, Reid S, Lanigan A, et al. Cerebral palsy in Victoria: Motor types, topography and gross motor function. J Paediatr Child Health 2005; 41(9−10): 479−83.

Laptook AR, O'Shea MT, Shankaran S, Bhaskar B. Adverse neu-rodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antece-dents. Pediatrics 2005; 115(3): 673−80.

Marlow N, Wolke D, Bracewell MA, Samara M. Neurologic and developmental disability at six years of age after extremely pre-term birth. N Engl J Med 2005; 352(1): 9−19.

Mongan D, Dunne K, O'Nuallain S, Gaffney G. Prevalence of ce-rebral palsy in the West of Ireland 1990-1999. Dev Med Child Neurol 2006; 48(11): 892−5.

Beckung E, Hagberg G, Uldall P, Cans C. Surveillance of Cerebral Palsy in Europe. Probability of walking in children with cere-bral palsy in Europe. Pediatrics 2008; 121(1): e187−92.

Sigurdardottir S, Eiriksdottir A, Gunnarsdottir E, Meintema M, Ar-nadottir U, Vik T. Cognitive profile in young Icelandic children with cerebral palsy. Dev Med Child Neurol 2008; 50(5): 357−62.

Odding E, Roebroeck ME, Stam HJ. The epidemiology of cerebral palsy: incidence, impairments and risk factors. Disabil Rehabil 2006; 28(4): 183−91.

Pennefather PM, Tin W. Ocular abnormalities associated with ce-rebral palsy after preterm birth. Eye (Lond) 2000; 14(Pt 1): 78−81.

Objavljeno
2017/02/01
Broj časopisa
Rubrika
Originalni članak