Efikasnost nanokristalnog zamenika kosti bifaznog kalcijum-fosfata-poli-DL-laktid-ko-glikolida za popunjavanje infrakoštanih defekata parodoncijuma

  • Momir Z Stevanović Department of Periodontology, Faculty of Medicine, University of Kragujevac, Kragujevac, Serbia
  • Vladimir M Biočanin Department of Dentistry, Faculty of Pharmacy and Health, University of Travnik, Travnik, Bosnia and Herzegovina
  • Milica Nedić Department of Periodontology, Faculty of Medicine, University of Kragujevac, Kragujevac, Serbia Clinic of Periodontology and Oral Medicine, Faculty of Dentistry, Pančevo, Serbia
  • Nenad L Ignjatovic Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Belgrade, Serbia
DOI: https://doi.org/10.2298/6170
Ključne reči: bone resorption||, ||kost, resorpcija, bone substitutes||, zamenici, oral surgical procedures||, ||hirurgija, oralna, procedure, biocompatible materials||, ||biokompatibilni materijali, nanoparticles||, ||koloidi, treatment outcome||, ||lečenje, ishod,

Sažetak


Uvod/Cilj. Različiti koštani zamenici koriste se za punjenje i reparaciju infrakoštanih defekata. Cilj rada bio je da se uporedi nanokristalni materijal – bifazni kalcijum-fosfat poli-DL-laktid-ko-glikolid (BCP/PLGA) sa deproteinizovanom goveđom kosti (DPBB) i β-trikalcijum fosfatom (β-TCP) u terapiji humanih parodontalnih infrakoštanih defekata. Metode. U studiju su bilа uključenа 24 pacijenata sa bilateralnim, infrakoštanim defektima u regiji gornjeg prvog i drugog premolara i prvog gornjeg molara. Slučajnim izborom defekti su punjeni DPBB (BioOss®) – gornji premolar i β-TCP (RTR®) – prvi gornji molar. BCP/PLGA bio je postavljan u parodontalne defekte gornjih premolara i prvog gornjeg molara sa suprotne strane. Plak indeks (PI), indeks krvarenja gingive (BI), pozicija cementno-gleđnog pripoja (CEJ) i dubina parodontalnog džepa (PPD) mereni su preoperativno i šest meseci nakon operacije. Rezultati. Poređenjem BCP/PLGA i β-TCP grupe utvrđena je statistički značajna redukcija PPD i CEJ šest meseci nakon operacije. Redukcija PPD i CEJ bila je slična u grupama koje su tretirane sa BCP/PLGA i DPBB. Zaključak. Značajno smanjenje PPD i CEJ registrovano je u grupi sa BCP/PLGA u poređenju sa β-TCP grupom.

Reference

Nasr HF, Aichelmann-Reidy ME, Yukna RA. Bone and bone substitutes. Periodontology 2000; 19(1): 74−86.

Hanes PJ. Bone replacement grafts for the treatment of perio-dontal intrabony defects. Oral Maxillofac Surg Clin North Am 2007; 19(4): 499−512.

Baldini N, de Sanctis M, Ferrari M. Deproteinised bovine bone in periodontal and implant surgery. Dent Mater 2007; 27(1): 61−70.

Hammerle CH, Chiantella GC, Karring T, Lang NP. The effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implants. Clin Oral Impl Res 1998; 9(3): 151−62.

Tapety FI, Amizuka N, Uoshima K, Nomura S, Maeda T. A histo-logical evaluation of the involvement of Bio-Oss in osteoblas-tic differentiation and matrix synthesis. Clin Oral Implants Res 2004; 15(3): 315−24.

Richardson CR, Mellonig JT, Brunsvold MA, McDonnell HT, Cochran DL. Clinical evaluation of Bio-Oss: a bovine-derived xenograft for the treatment of periodontal osseous defects in humans. J Clin Periodontol 1999; 26(7): 421−8.

Scabbia A, Trombelli L. A comparative study on the use of a HA/collagen/chondroitin sulphate biomaterial (Biostite) and a bovine-derived HA xenograft (Bio-Oss) in the treatment of deep intra-osseous defects. J Clin Periodontol 2004; 31(5): 348−55.

Neamat A, Gawish A, Gamal-Eldeen AM. beta-Tricalcium phos-phate promotes cell proliferation, osteogenesis and bone regeneration in intrabony defects in dogs. Arch Oral Biol 2009; 54(12): 1083−90.

Jensen SS, Broggini N, Hjørting-Hansen E, Schenk R, Buser D. Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of minipigs. Clin Oral Implants Res 2006; 17(3): 237−43.

Ignjatovic N, Ajdukovic Z, Uskokovic D. New biocomposite [bi-phasic calcium phosphate/ poly-DL-lactide-co-glycolide/biostimulative agent] filler for reconstruction of bone tissue changed by osteoporosis. J Mater Sci Mater Med 2005; 16(7): 621−6.

Zhang P, Hong Z, Yu T, Chen X, Jing X. In vivo mineralization and osteogenesis of nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide). Biomaterials 2009; 30(1): 58−70.

Ignjatović NL, Liu CZ, Czernuszka JT, Uskoković DP. Micro- and nano-injectable composite biomaterials containing calcium phosphate coated with poly(DL-lactide-co-glycolide). Acta Biomater 2007; 3(6): 927−35.

Ignjatović N, Suljovrujić E, Budinski-Simendić J, Krakovsky I, Us-koković D. Evaluation of Hot-Pressed Hydroxyapatite/Poly-L-lactide Composite Biomaterial Characteristics. J Biomed Mater Res B Appl Biomater 2004; 71(2): 284−94.

Ignjatovic N, Uskokovic D. Biodegradable composites based on nano-crystalline calcium phosphate and bioresorbable poly-mers. Advanced Appl Cer 2008; 107(3): 142−7.

Ignjatovic N, Uskokovic V, Ajdukovic Z, Uskokovic D. Multi-functional hydroxyapatite and poly (D, L-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol. Mater Sci Eng C Mater Biol Appl 2013; 33(2): 943−50.

Ignjatović N, Ninkov P, Kojić V, Bokurov M, Srdić V, Krnojelac D, et al. Cytotoxicity and fibroblast properties during in vitro test of biphasic calcium phosphate/poly-dl-lactide-co-glycolide biocomposites and different phosphate materials. Microsc Res Tech 2006; 69(12): 976−82.

Unger RE, Huang Q, Peters K, Protzer D, Paul D, Kirkpatrick CJ. Growth of human cells on polyethersulfone (PES) hollow fi-ber membranes. Biomaterials 2005; 26(14): 1877−84.

Ignjatovic N, Nastovic A, Latinovic V, Onjia A, Miljkovic M, Kon-stantinovic V. Preparation and properties of polymeric and composite bioresorbable barrier membranes. Mater Sci Forum 2004; 453−4: 537−42. (Serbian)

Vonarbourg A, Passirani C, Saulnier P, Benoit J. Parameters influ-encing the stealthiness of colloidal drug delivery systems. Bio-materials 2006; 27(24): 4356−73.

Saini N, Sikri P, Gupta H. Evaluation of the relative efficacy of autologous platelet-rich plasma in combination with β-tricalcium phosphate alloplast versus an alloplast alone in the treatment of human periodontal infrabony defects: a clinical and radiological study. Indian J Dent Res 2011; 22(1): 107−15.

Merten HA, Wiltfang J, Grohmann U, Hoenig JF. Intraindividual comparative animal study of alpha- and beta-tricalcium phosphate degradation in conjunction with simultaneous in-sertion of dental implants. J Craniofac Surg 2001; 12(1): 59−68.

Kim SS, Kim BS. Comparison of osteogenic potential between apatite-coated poly(lactide-co-glycolide)/hydroxyapatite par-ticulates and Bio-Oss®. Dent Mater J 2008; 27(3): 368−75.

Cordaro L, Bosshardt DD, Palattella P, Rao W, Serino G, Chiapasco M. Maxillary sinus grafting with Bio-Oss or Straumann Bone Ceramic: histomorphometric results from a randomized con-trolled multicenter clinical trial. Clin Oral Implants Res 2008; 19(8): 796−803.

Sartori S, Silvestri M, Forni F, Icaro Comaglia A, Tesei P, Cattaneo V. Ten-year follow-up in a maxillary sinus augmentation using anorganic bovine bone (Bio-Oss). A case report with his-tomorphometric evaluation. Clin Oral Implants Res 2003; 14(3): 369−72.

Schlegel AK, Donath K. BIO-OSS - a resorbable bone substitute. J Long Term Eff Med Implants 1998; 8(3−4): 201−9.

Thaller SR, Hoyt J, Dart A, Borjeson K, Tesluk H. Repair of ex-perimental calvarial defects with Bio-Oss particles and collagen sponges in a rabbit model. J Craniofac Surg 1994; 5(4): 242−6.

Ellegaard B, Löe H. New attachment of periodontal tissues after treatment of intrabony lesions. J Periodontol 1971; 42(10): 648−52.

Objavljeno
2015/11/02
Broj časopisa
Vol. 72 Br. 8 (2015)
Rubrika
Originalni članak