Prenatalna dijagnoza lizencefalije

  • Nataša Cerovac Clinic for Neurology and Psychiatry for Children and Youth, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Milan Terzić Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia
  • Milan Borković Clinic for Neurology and Psychiatry for Children and Youth, Belgrade, Serbia
  • Nevena Divac Faculty of Medicine, University of Belgrade, Belgrade, Serbia §Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Radan Stojanović Faculty of Medicine, University of Belgrade, Belgrade, Serbia Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Milica Prostran Faculty of Medicine, University of Belgrade, Belgrade, Serbia Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
DOI: https://doi.org/10.2298/6563
Ključne reči: lissencephaly||, ||lizencefalija, fetal monitoring||, ||fetus, praćenje, ultrasonography||, ||ultrazvuk, magnetic resonance imaging||, ||magnetna rezonanca, snimanje, mental retardation||, ||mentalna zaostalost,

Sažetak


Uvod. Lizencefalija („gladak mozak”) predstavlja važnu grupu malformacija mozga koja nastaje zbog poremećaja neuronske migracije. Može uzrokovati teško zaostajanje u intelektualnom i motornom razvoju i epilepsiju kod dece. Prenatalna dijagnostika ovog poremećaja je retka. Prikaz bolesnika. Prikazali smo jedan slučaj prenatalno dijagnostikovane lizencefalije. Trudnica, stara 30 godina, upućena je u bolnicu u 35. nedelji gestacije radi magnetne rezonancije (MR) posle ultrazvučnog pregleda koji je ukazao na fetalnu moždanu ventrikulomegaliju. Fetalni MR pregled mozga pokazao je glatku koru, sa izostankom razvoja vijuga. Dete ženskog pola rođeno je u terminu, telesne mase 2 500 g i Apgar skora 8, a pokazalo je usporen rani razvoj. Postnatalni ultrazvučni i MR pregled mozga potvrdili su dijagnozu lizencefalije. Devojčica sada ima 8 godina i kliničku sliku spastične kvadripareze, mentalne retardacije i epilepsije. Zaključak. Potvrda ultrazvučne dijagnoze putem MR pregleda značajna je za prenatalnu dijagnostiku lizencefalije.

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Objavljeno
2017/01/23
Broj časopisa
Vol. 73 Br. 1 (2016)
Rubrika
Prikaz bolesnika