Nesimptomatični tok bolesti Rosai-Dorfman

  • Dragan Petrović Department of Maxillofacial Surgery, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
  • Dragan Mihailović Department of Pathology, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
  • Sladjana Petrović Department of Radiology, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
  • Nikola Živković Department of Pathology, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
  • Žaklina Mijović Department of Pathology, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
  • Bojko Bjelaković Department of Pediatrics, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
  • Miloš Kostić Department of Immunology, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
  • Ljiljana Kesić Department of Oral Medicine, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
  • Ana Stanković Clinic of Oncology, Clinical Center of Niš, Serbia
  • Milica Petrović Department of Oral Medicine, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
  • Ivica Vučković Department of Maxillofacial Surgery, Clinic of Stomatology, Faculty of Medicine, University of Niš, Niš, Serbia
DOI: https://doi.org/10.2298/2342
Ključne reči: histiocytosis, sinus||, ||histiocitoza, sinusna, diagnosis, differential||, ||dijagnoza, diferencijalna, immunohistochemistry||, ||imunohistohemija, treatment outcome||, ||lečenje, ishod,

Sažetak


Uvod. Sinusna histiocitoza sa masivnom limfadenopatijom je retka benigna bolest nepoznate etiologije. Zahvaćenost pljuvačnih žlezda ukazuje na ekstramodularni karakter bolesti i često zahvata imunohistohemijsko bojenje hirurški odstranjenog tumora za potvrdu dijagnoze. Prikaz bolesnika. U radu je prikazan bolesnik, star 43 godine, sa bezbolnim tumorom u predelu levog ugla donje vilice. Kliničkim pregledom ustanovljena je bezbolna, pokretna, elastična čvoričasta struktura, promera 4 × 3 cm sa neizmenjenom kožom. Promena istih karakteristika, promera 2 × 2 cm, takođe je primećena u desnoj parotidnoj regiji. Regionalni limfni nodusi su bili urednog izgleda. Makroskopski, promena je bila čvrste konzistencije, kružna, multilobulirana, žućkaste prebojenosti. Mikroskopski, promena je bila uglavnom izgrađena od histiocita svetle citoplazme sa emperipolezom, plazma ćelija i limfocita, koji su bili raspoređeni difuzno i u grupama. Imunohistohemijski, histiociti su bili CD68 i S 100 protein pozitivni. Zaključak. Rosai-Dorfman je benigna bolest, na koju se često ne misli, te može biti pogrešno interpretirana kao neoplastična bolest.

Reference

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Objavljeno
2015/04/23
Broj časopisa
Vol. 71 Br. 8 (2014)
Rubrika
Prikaz bolesnika