The relation between nonspecific hyperreactivity of the airways and atopic constitution in asthmatics

Dobrivoje Novković; Marina Petrović; Vladan Živkovic; Nenad Baletić

doi:10.2298/VSP141029120N

Dobrivoje Novković Clinic for Pulmonary Diseases,Military Medical Academy, Belgrade, Serbia
Marina Petrović Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Vladan Živkovic Clinic for Pulmonary Diseases,Military Medical Academy, Belgrade, Serbia
Nenad Baletić Clinic for Ear, Nose and Throat, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia

DOI: https://doi.org/10.2298/VSP141029120N

Ključne reči: asthma||, ||astma, respiratory hypersensitivity||, ||hipersenzibilnost, respiratorna, immunoglobulin e||, ||ige, hypersensitivity, immediate||, rana, histamine||, ||histamin, skin test||, ||koža, testovi,

Sažetak

Uvod/Cilj. Hiperreaktivnost disajnih puteva uzrokovana inflamacijom kod astmatičara je najznačajnija patofiziološka promena. Ona predstavlja pogodan teren da se u prisustvu faktora rizika i pokretača astme ispolji astmatični napad. Atopijska konstitucija je jedan od najznačajnijih faktora rizika od nastanka i ispoljavanja astme. Cilj našeg rada bio je da se ispita odnos između nespecifične hiperreaktivnosti disajnih puteva i atopijske konstitucije kod astmatičara. Metode. Izvršena je retrospektivna analiza rezultata nespecifičnog bronhoprovokacijskog testa sa histaminom, kožnih proba na inhalacione alergene i nivoa ukupnih IgE u serumu bolesnika sa kontrolisanom bronhijalnom astmom. U analizu su bila uključena 162 astmatičara, ispitivana tokom jednogodišnjeg perioda. Rezultati. Svi bolesnici su bili muškarci, starosti od 18 do 30 godina. Utvrđeno je da su ispitanici sa izraženijom nespecifičnom hiperreaktivnošću imali izraženiju kožnu reakciju na inhalacione alergena i viši nivo ukupnih IgE u serumu. Zaključak. Rezultati našeg istraživanja ukazuju na to da je intenzitet hiperreaktivnosti disajnih puteva na histamin kod astmatičara u direktnoj vezi sa atopijskom konstitucijom.

Biografije autora

Dobrivoje Novković, Clinic for Pulmonary Diseases,Military Medical Academy, Belgrade, Serbia

specijalista pulmolog

Marina Petrović, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

specijalista pulmolog

Vladan Živkovic, Clinic for Pulmonary Diseases,Military Medical Academy, Belgrade, Serbia

lekar na specijalizaciji

Nenad Baletić, Clinic for Ear, Nose and Throat, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia

specijalista otorinolaringolog

Reference

Cockcroft D, Davis B. Direct and indirect challenges in the clini-cal assessment of asthma. Ann Allergy Asthma Immunol 2009; 103(5): 363−9.

Brannan JD, Turton JA. The Inflammatory Basis of Execise In-duced Bronchoconstriction. Phys Sportsmed 2010; 38(4): 67−73.

Busse WW. The relationship of airway hyperresponsiveness and airway inflammation: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 2010; 138(2 Suppl): 4s−10s.

Anderson SD, Brannan JD. Bronchial Provocation Testing: The Future. Curr Opin Allergy Clin Immunol 2011; 11(1): 46−52.

Maurer M, Simonett D, Brutsche MH.. Challenge of exercise-induced asthma and exercise-induced bronchoconstriction. Expert Rev Respir Med 2009; 3(1): 13−9.

McGrath KW1, Fahy JV. Negative methacholine challenge tests in subjects who report physician-diagnosed asthma. Clin Exp Allergy 2011; 41(1): 46−51.

Kim BS, Jin HS, Kim HB, Lee SY, Kim JH, Kwon JW, et al. Air-way hyperresponsiveness is associated with total serum immu-noglobulin E and sensitization to aeroallergens in Korean adolescents. Pediatr Pulmonol 2010; 45(12): 1220−7.

Kim YM, Kim YS, Jeon SG, Kim YK. Immunopathogenesis of Allergic Asthma: More Than the Th2 Hypothesis. Allergy Asthma Immunol Res 2013; 5(4): 189–96.

Kennedy JL, Heymann PW, Platts-Mills TA. The role of allergy in severe asthma. Clin Exp Allergy 2012; 42(5): 659−69.

Backer V, Ulrik CS, Hansen KK, Laursen EM, Dirksen A, Bach-Mortensen N. Atopy and bronchial responsiveness in random population sample of 527 children and adolescents. Ann Allergy 1992; 69(2): 116−22.

Plaschke P, Janson C, Norrman E, Björnsson E, Ellbjär S, Järvholm B. Association between atopic sensitization and asthma and bronchial hyperresponsiveness in swedish adults: pets, and not mites, are the most important allergens. J Allergy Clin Immunol 1999; 104(1): 58−65.

Odnos između nespecifične hiperreaktivnosti disajnih puteva i atopijske konstitucije kod astmatičara

Sažetak

Biografije autora

Reference