Najčešći bakterijski uzročnici kod hospitalizovanih bolesnika sa akutnim pogoršanjem hronične opstruktivne bolesti pluća

Violeta Kolarov; Biljana Zvezdin; Mrina Djurić; Mirjana Hadnadjev; Sanja Hromiš; Katarina Nikoletić; Bojana Trivić

doi:10.2298/VSP141219176K

Violeta Kolarov Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia
Biljana Zvezdin Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Mrina Djurić Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Mirjana Hadnadjev Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Sanja Hromiš Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Katarina Nikoletić Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Bojana Trivić Boehringer Ingelheim Serbia, Belgrade, Serbia

DOI: https://doi.org/10.2298/VSP141219176K

Ključne reči: pulmonary disease, chronic obstructive||, ||pluća, opstruktivne bolesti, hronične, acute disease||, ||akutna bolest, diagnostic techniques and procedures||, ||dijagnostičke tehnike i procedure, sputum||, ||ispljuvak, bacteriological techniques||, ||bakteriološke tehnike, pseudomonas aeruginosa||, ||pseudomonas aeruginosa, haemophilus influenzae||, ||haemophilus influenzae, streptococcus pneumoniae||, ||streptococcus pneumoniae, mortality||, ||mortalitet,

Sažetak

Uvod/Cilj. Infekcija je glavni uzročnik akutnog pogoršanja hronične opstruktivne bolesti pluća (AEHOBP). Cilj rada bio je da se odrede najčešći bakterijski uzročnici AEHOBP kod bolesnika koji su hospitalizovani u ustanovi tercijernog ranga. Metode. Ova retrospektivna studija obuhvatila je bolesnike hospitalizovane na Institutu za plućne bolesti Vojvodine zbog infektivne AEHOBP u periodu od jedne godine. Analizirali smo kliničke podatke, spirometriju, bakterteriološki nalaz sputuma i ishod bolesti. Rezultati. U studiju je bio uključen ukupno 81 bolesnik, 47 muškaraca (58,02%) i 34 žene (41,97%), prosečne starosti 65,7 godina, prosečnog trajanja bolesti 14,5 godina. Prosečni forsirani ekspiratorni volumen u jednoj sekundi (FEV₁) bio je 30,12%. Najčešći izolovani patogen bio je Pseudomonas aeruginosa (n = 36, 38,29%), potom Haemophilus influenzae ( n = 25, 26,59%) i Streptococcus pneumoniae (n = 16, 17,02%). Mešana infekcija bila je prisutna kod 9 (9,57%) bolesnika. Prosečni (FEV₁) kod bolesnika sa izolovanim Pseudomonas aeruginosa iznosio je 28,67%, sa izolovanim Haemophilus influenzae 37,23% i sa izolovanim Streptococcus pneumoniae 42,26%. Ukupan letalitet iznosio je 6,2%. Svi (100%) preminuli imali su infekciju uzrokovanu Pseudomonas aeruginosa-om. Postojala je statistički značajna razlika u vrednosti FEV₁ između grupa bolesnika sa ili bez izolovanog Pseudomonas aeruginosa u sputumu (p = 0.016). Zaključak. Najčešći izolovani uzročnici AEHOBP bili su Pseudomonas aeruginosa, Haemophilus influenzae i Streptococcus pneumoniae. Ukupan letalitet iznosio je 6,2%. Svi (100%) preminuli imali su infekciju uzrokovanu Pseudomonas aeruginosa-om.

Biografije autora

Violeta Kolarov, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia

Izabrana u zvanje asistenta decembra 2012. godine

Odbranila doktorsku disertaciju 2014.

Biljana Zvezdin, Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia

Odeljenje za astmu

Prof. dr sc. med.

Mrina Djurić, Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia

Odeljenje za opštu pulmologiju

Prof. dr sc. med.

Mirjana Hadnadjev, Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia

Centar za mikrobiologiju

Doktor mikrobiolog

Sanja Hromiš, Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia

Odeljenje za astmu

Primarijus dr

Katarina Nikoletić, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

Zavod za nuklearnu medicinu

Prim. dr sci. med.

Bojana Trivić, Boehringer Ingelheim Serbia, Belgrade, Serbia

Mr ph spec.

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