Kvantifikacija mastocita u različitim stadijumima parodontalne bolesti

  • Dragan Marjanović Dental Clinic, Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia
  • Zlatibor Anđelković Institute for Histology and Embryology, Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia
  • Zlata Brkić Dental Clinic, Military Medical Academy, Belgrade, Serbia; §Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia
  • Goran Videnović Dental Clinic, Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia
  • Meliha Šehalić Dental Clinic, Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia
  • Vladimir Matvijenko Dental Clinic, Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia
  • Snežana Leštarević Dental Clinic, Military Medical Academy, Belgrade, Serbia
  • Nadica Đorđević Dental Clinic, Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia
DOI: https://doi.org/10.2298/VSP141222030M
Ključne reči: periodontal diseases||, ||periodontalne bolesti, disease progression||, ||bolest, progresija, mast cells||, ||mast ćelije,

Sažetak


Uvod/Cilj. Mastociti su mononukleusne ćelije poreklom iz koštane srži. Oni proizvode brojne biološki aktivne supstance, usled čega aktivno učestvuju u imunim i inflamatornim procesima kod parodontalne bolesti. U istraživanju je praćena distribucija i gustina mastocita u zdravoj gingivi i u različitim fazama parodontalne bolesti. Metode. Materijal je dobijen gingivalnom biopsijom kod 96 bolesnika razvrstanih u 4 grupe: zdrava gingiva, gingivitis, početna parodontopatija i uznapredovala parodontopatija. Za identifikaciju mastocita korišćeno je toluidin plavo bojenje po Spiceru. Rezultati. Prema našem istraživanju gustina mastocita u gingivalnom vezivu raste sa progresijom infekcije, što znači da su mastociti u gingivitisu brojniji u odnosu na zdravu gingivu, a u parodontopatiji brojniji u poređenju sa gingivitisom. Zaključak. Povećanje broja mastocita u inficiranoj gingivi može se dovesti u vezu sa pojačanim influksom inflamatornih ćelija iz cirkulacije u stromu gingive, ali i sa lizom kolagena budući da ove ćelije proizvode supstance sa kolagenolitičkim potencijalom. Na osnovu distribucije mastocita može se zaključiti da u evoluciji parodontalne bolesti postoje značajne dinamičke alteracije u migraciji i lokalizaciji ovih ćelija.

 

 


 

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Objavljeno
2017/03/07
Broj časopisa
Vol. 73 Br. 5 (2016)
Rubrika
Originalni članak