Izazovi u lečenju postinfarktnog septalnog defekta i srčane slabosti
Sažetak
Uvod. Stečeni ventrikularni septalni defekt (VSD) je retka ali ozbiljna mehanička komplikacija akutnog infarkta miokarda sa lošom prognozom i visokom stopom mortaliteta kod bolesnika lečenih hirurškim putem ili konzervativno. Prikaz bolesnika. U radu je prikazan bolesnik, star 58 godina, koji je primljen u našu instituciju šest dana nakon akutnog infarkta miokarda, komplikovanim rupturom inferoseptalnog dela septuma i znacima srčane insuficijencije. Koronarografija urađena u regionalnoj bolnici pokazala je trosudovnu koronarnu bolest sa proksimalno okludiranom, dominantnom, desnom koronarnom arterijom. Transtorakalnim ehokardiografskim pregledom ustanovljena je aneurizma vrlo istanjenog inferiornog septuma i bazalnog dela inferiornog zida leve komore, sa rupturom septuma. Jedna od dimenzija defekta bila je 15 mm, sa izračunatim Qp: Qs odnosom od 2 : 1. S obzirom na to da je bolesnik bio pod jako visokim rizikom od hirurške korekcije defekta, odlučeno je da se pristupi transkateterskom zatvaranju VSD, kao boljoj opciji za bolesnika. Pod kratkom intravenskom sedacijom, postavljen je Amplatzer okluder 24 mm, uz neprekidnu transezofagealnu ehokardiografiju. Postproceduralnim ehokardiografskim pregledom ustanovljeno je prisustvo malog rezidualnog šanta, ali uz značajno poboljšanje hemodinamskog statusa. Na bolesnikovom 24-časovnom Holter elektrokardiogramu nisu registrovani poremećaji srčanog ritma. Deset dana nakon intervencije, urađena je ponovna koronarografija i stentiranje cirkumflekne arterije i ramus intermedijusa. Ostijalna lezija na prednjoj descedentnoj arteriji ostavljena je za dalju funckionalnu dijagnostiku. Zaključak. Transkatetersko zatvaranje ventrikularnog septalnog defekta septalnim okluderom može biti definitivni način lečenja bolesnika sa anatomski pogodnim defektima, ali i poslužiti za premošćavanje do hirurškog lečenja.
Reference
Crenshaw BS, Granger CB, Birnbaum Y, Pieper KS, Morris DC, Kleiman NS, et al.. Risk factors, angiographic patterns, and out-comes in patients with ventricular septal defect complicating acute myocardial infarction. GUSTO-I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) Trial Investigators. Circulation 2000; 101(1): 27−32.
Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiolo-gy/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial In-farction). Circulation 2004; 110(5): 588−636.
Bouchart F, Bessou JP, Tabley A, Redonnet M, Mouton-Schleifer D, Haas-Hubscher C, et al. Urgent surgical repair of postinfarction ventricular septal rupture: early and late outcome. J Card Surg 1998; 13(2): 104−12.
Menon V, Webb JG, Hillis LD, Sleeper LA, Abboud R, Dzavik V, et al. Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction: a report from the SHOCK Trial Registry. Should we emergently revascularize Occluded Coronaries in cardiogenic shock. J Am Coll Cardiol 2000; 36(3 Suppl A): 1110−6.
Moore CA, Nygaard TW, Kaiser DL, Cooper AA, Gibson RS. Postinfarction ventricular septal rupture: the importance of lo-cation of infarction and right ventricular function in determin-ing survival. Circulation 1986; 74(1): 45−55.
Mantovani V, Mariscalco G, Leva C, Blanzola C, Sala A. Surgical repair of post-infarction ventricular septal defect: 19 years of experience. Int J Cardiol 2006; 108(2): 202−6.
Deja MA, Szostek J, Widenka K, Szafron B, Spyt TJ, Hickey MS, et al. Post infarction ventricular septal defect - can we do better. Eur J Cardiothorac Surg 2000; 18(2): 194−201.
Maltais S, Ibrahim R, Basmadjian A, Carrier M, Bouchard D, Cartier R, et al. Postinfarction ventricular septal defects: towards a new treatment algorithm. Ann Thorac Surg 2009; 87(3): 687−92.
Thiele H, Kaulfersch C, Daehnert I, Schoenauer M, Eitel I, Borger M, et al. Immediate primary transcatheter closure of postinfarction ventricular septal defects. Eur Heart J 2009; 30(1): 81−8.
Bialkowski J, Szkutnik M, Kusa J, Kalarus Z, Gasior M, Przybylski R, et al. Transcatheter closure of postinfarction ventricular septal defects using Amplatzer devices. Rev Esp Cardiol 2007; 60(5): 548−51. (Spanish)
Attia R, Blauth C. Which patients might be suitable for a septal occluder device closure of postinfarction ventricular septal rupture rather than immediate surgery. Interact Cardiovasc Thorac Surg 2010; 11(5): 626−9.
Holzer R, Balzer D, Amin Z, Ruiz CE, Feinstein J, Bass J, et al. Transcatheter closure of postinfarction ventricular septal defects using the new Amplatzer muscular VSD occluder: Results of a U.S. Registry. Catheter Cardiovasc Interv 2004; 61(2): 196−201.