Primena hijaluronske i aminokapronske kiseline u terapiji alveolitisa

  • Dejan N Dubovina Department of Oral Surgery, Faculty of Medicine, University of Priština Kosovska Mitrovica, Kosovska Mitrovica, Serbia
  • Branko Mihailović Department of Oral Surgery, Faculty of Medicine, University of Priština Kosovska Mitrovica, Kosovska Mitrovica, Serbia
  • Zoran Bukumirić Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Zoran Vlahović Department of Oral Surgery, Faculty of Medicine, University of Priština Kosovska Mitrovica, Kosovska Mitrovica, Serbia
  • Milan Miladinović Department of Oral Surgery, Medical Faculty, University in Pristina, Kosovska Mitrovica, Serbia
  • Nikola Miković Clinic of Maxillofacial Surgery, Faculty of Dentistry, University of Belgrade, Belgrade, Serbia
  • Zoran Lazić Clinic of Dental Medicine, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia
DOI: https://doi.org/10.2298/VSP150304125D
Ključne reči: tooth extraction||, ||zub, ekstrakcija, postoperative complications||, ||postoperativne komplikacije, dry socket||, ||alveolitis, suvi, hyaluronic acid||, ||hijaluronska kiselina, aminocaproic acids||, ||aminokapronske kiseline, curettage||, ||kiretaža,

Sažetak


Uvod/Cilj. Alveolitis je relativno česta postekstrakciona komplikacija. Nastaje, najverovatnije, usled izrazite fibrinolitičke aktivnosti u koagulumu, a karakteriše se pojavom intezivnog bola. Cilj ove kliničke studije bio je da se ispita mogućnost primene hijaluronske i aminokapronske kiseline u terapiji alveolitisa. Metode. Studija je uključila 60 pacijenata sa kliničkom dijagnozom alveolitisa. U odnosu na primenjenu nefarmakološku meru svi pacijenti su bili podeljeni u dve grupe sa po 30 pacijenata: ispiranje – ispiranje obolele alveole sterilnim fiziološkim rastvorom; kiretaža – pažljiva kiretaža. Obe ove grupe, u odnosu na primenjeni tretman [(hijaluronska kiselina, hijaluronska kiselina + aminokapronska kiselina, Alvogyl® (kombinacija anestetika i antiseptika u obliku paste)], bile su podeljene u tri podgrupe sa po 10 pacijenata po sledećem protokolu: 0,2 mL hijaluronske kiseline u obliku 0.8% gela; 2 mL aminokapronske kiseline i hijaluronske kiseline; Alvogyl®. Na kontrolnim pregledima, zakazanim na svaka dva dana do potpunog prestanka bolnih senzacija, pacijentima je ponavljana terapijska opcija sa prvog pregleda. Evidentiran je broj prisutnih simptoma i znakova alveolitisa kod pacijenata, kao i nivo bola (meren pomoću vizuelno-analogne skale). Rezultati. Primenom hijaluronske kiseline, sa ili bez aminokapronske kiseline, postignuto je statistički značajno brže sniženje bolnih senzacija kao i smanjenje broja prisutnih simptoma i znakova alveolitisa u odnosu na upotrebu Alvogyl®-a. Zaključak. Hijaluroska kiselina, samostalno ili u kombinaciji sa aminokapronskom kiselinom, značajno snižava bol, te se može uspešno primenjivati u terapiji alveolitisa.

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Objavljeno
2017/03/13
Broj časopisa
Vol. 73 Br. 11 (2016)
Rubrika
Originalni članak