Hiperkalcemični tip sitnoćelijskog karcinoma jajnika

  • Milena B. Ilić Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Dalibor V. Jovanović Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Miloš Z. Milosavljević Department of Pathology, Clinical Center Kragujevac, Kragujevac, Serbia
  • Vesna Stanković Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Department of Pathology, Clinical Center Kragujevac, Kragujevac, Serbia
  • Gordana Djordjević Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Zoran Protrka Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Department of Gynaecology and Obstretics, Clinical Center Kragujevac, Kragujevac, Serbia
  • Jasmina Nedović Department of Oncology, Clinical Center Kragujevac, Kragujevac, Serbia
  • Slobodanka Lj. Mitrović Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Department of Pathology, Clinical Center Kragujevac, Kragujevac, Serbia
DOI: https://doi.org/10.2298/3215
Ključne reči: carcinoma, small cell||, ||karcinom malih ćelija, ovarian neoplasms||, ||jajnik, neoplazme, diagnosis||, ||dijagnoza, immunohistochemistry||, ||imunohistohemija, neoplasm metastasis||, ||neoplazme, metastaze, treatment outcome||, ||lečenje, ishod,

Sažetak


Uvod. Ekstrapulmonalni sitnoćelijski karcinom je retka, prognostički loša kategorija tumora. Primarno, može da se lokalizuje u skoro svim organima, pa i u jajniku, gde zbog svojih kliničkih specifičnosti, često predstavlja pravi dijagnostički i terapijski izazov. Sitnoćelijski karcinom jajnika (small cell ovarian carcinoma – SCOC)  biološki je vrlo agresivan maligni tumor nepoznate histogeneze. U radu je prikazana bolesnica u post-menopauzi sa sitnoćelijskim karcinomom jajnika i hiperkalcemijom, agresivnog toka i fatalnog ishoda, u International Federation of Gynecology and Obstetrics – FIGO Ia stadijumu. Prikaz bolesnika. Žena stara 60 godina, javila se zbog tegoba u donjem abdomenu praćenih bolom jakog intenziteta. Ultrazvučnim pregledom i kompjuterizovanom tomografijom abdomena ustanovljeno je prisustvo velike adneksalne mase cističnog izgleda sa najvećim promerom od 13 cm, sa urednom strukturom drugih ginekoloških organa i bez prisustva metastatskih depozita. Svi rezultati laboratorijske analize bili su u granicama normalnih vrednosti izuzev povišenih nivoa kalcijuma u serumu. Izvršena je eksplorativna laparotomija sa kompletnom histerektomijom, bileteralnom salpingooforektomijom, disekcijom limfnih čvorova i omentektomijom. Na osnovu patohistološke analize operatvnog materijala postavljena je dijagnoza SCOC stadijuma Ia. U postoperativnom periodu nije bilo komplikacija i bolesnica je otpuštena deset dana posle operacije u dobrom stanju i normalizovanom kalcemijom. Lečenje je nastavljeno istovremenom radio- i hemioterapijom. Međutim, bez obzira na preduzete mere lečenja, bolest je progradirala i bolesnica je umrla zbog diseminovane metastatske bolesti 26 meseci posle postavljanja dijagnoze. Zaključak. Sitnoćelijski karcinom lokalizovan u jajniku najčešće je kategorija tumora sa lošom prognozom u zavisnosti od faze bolesti.

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Objavljeno
2015/07/08
Broj časopisa
Vol. 72 Br. 3 (2015)
Rubrika
Prikaz bolesnika