Organizovano ispitivanje kolorektalnog karcinoma – prvi ciklus tokom 2013–2014.
Sažetak
Uvod/Cilj. Nacionalni program organizovanog ispitivanja kolorektalnog karcinoma sproveden je u Republici Srbiji tokom 2013. i 2014. godine, obuhvatajući stanovništvo oba pola, starosti 50–74 godine, u 28 od 180 opština, sa ciljnom populacijom od 651 445 ljudi. Program ima za cilj sniženje mortaliteta od kolorektalnog karcinoma u ciljnoj populaciji. Cilj rada bio je da se prikažu rezultati organizovanog ispitivanja kolorektalnog karcinoma tokom dvogodišnjeg perioda u Srbiji. Metode. Izabrani lekari iz domova zdravlja pozivali su pismom i telefonom ciljnu populaciju da urade imunohemijski FOB test za otkrivanje okultnog krvarenja u stolici. Osobe sa pozitivnim nalazom testa upućivane su na kolonoskopiju. Korišćena je baza podataka osiguranika i ostalih građana ciljne populacije u pozivanju na snimanje u domovima zdravlja. Rađena je deskriptivna statistička analiza rezultata u organizovanom ispitivanju kolorektalnog karcinoma u prvom dvogodišnjem ciklusu, za ključne indikatore ispitivanja. Rezultati. U prvom ciklusu bile su pozvane ukupno 99 592 osobe. Odziv na testiranje bio je 62,5%. Kolonoskopija je urađena kod 1 554 osobe. Adenomi su otkriveni kod 586 osoba (0,9% svih testiranih), tj. 37,7% svih kolonoskopiranih. Kod 129 osoba otkriven je kolorektalni karcinom (0,2% svih testiranih), tj. kod 8,3% svih kolonoskopiranih. U levoj polovini kolona (rektumu, sigmoidnom i descedentnom kolonu) bilo je 70,4% dijagnostikovanih polipa i 77,3% karcinoma, dok je 29,6% polipa i 22,7% karcinoma bilo u proksimalnim delovima kolona. Zaključak. U prvom ciklusu organizovanog ispitivanja kolorektalnog karcinoma u Srbiji odziv ciljne populacije na testiranje bio je visok i predstavljao je ohrabrujući rezultat. Očekuje se da će u narednim ciklusima biti postignuta čak i veća pokrivenost ciljne populacije. Pozitivna vrednost predviđanja urađenih kolonoskopija pokazuje da će se daljim radom na praćenju stadijuma otkrivenih adenoma i karcinoma dostići ciljevi očekivanog napretka u ranoj dijagnozi kolorektalnog karcinoma u Srbiji.
Reference
Bastos J, Peleteiro B, Gouveia J, Coleman MP, Lunet N. The state of the art of cancer control in 30 European countries in 2008. Int J Cancer 2010; 126(11): 2700−15.
Altobelli E, Lattanzi A, Paduano R, Varassi G, di Orio F. Colo-rectal cancer prevention in Europe: Burden of disease and sta-tus of screening programs. Prev Med 2014; 62: 132−41.
Institute of Public Health of Serbia “Dr Milan Jovanovic Ba-tut”. Cancer incidence and mortality in central Serbia 2012. In: Cancer registry of central Serbia. Report. Belgrade: Institute of Public Health of Serbia “Dr Milan Jovanovic Batut”; 2012.
von Karsa L, Patnick J, Segnan N. European guidelines for quality assurance in colorectal cancer screening and diagnosis. 1st ed.Executive summary. Endoscopy 2012; 44 Suppl 3: SE1−8.
Regulation on the National Programe on early detection of co-lorectal cancer. “Official Gazette of RS” 2013/73. (Serbian)
Levin TR, Jamieson L, Burley DA, Reyes J, Oehrli M, Caldwell C. Organized Colorectal Cancer Screening in Integrated Health Care Systems. Epidemiol Rev 2011; 33(1): 101−10.
Blom J, Kilpelainen S, Hultcrantz R, Tornberg S. Five-year expe-rience of organized colorectal cancer screening in a Swedish population - increased compliance with age, female gender, and subsequent screening round. J Med Screen 2014; 21(3): 144−50.
Guy GP, Richardson LC, Pignone MP, Plescia M. Costs and bene-fits of an organized fecal immunochemical test-based colorec-tal cancer screening program in the United States. Cancer 2014; 120(15): 2308−15.
Rabeneck L, Tinmouth JM, Paszat LF, Baxter NN, Marrett LD, Ruco A, et al. Ontario's ColonCancerCheck: results from cana-da's first province-wide colorectal cancer screening program. Cancer Epidemiol Biomarkers Prev 2014; 23(3): 508−15.
Stock C, Holleczek B, Hoffmeister M, Stolz T, Stegmaier C, Brenner H. Adherence to Physician Recommendations for Surveillance in Opportunistic Colorectal Cancer Screening: The Necessity of Organized Surveillance. PLoS One 2013; 8(12): e82676.
Charters TJ, Strumpf EC, Sewitch MJ. Effectiveness of an orga-nized colorectal cancer screening program on increasing adhe-rence in asymptomatic average-risk Canadians. BMC Health Serv Res 2013; 13(1): 449.
Spayne M, Rabeneck L, Guerriero L. Successes and Challenges in Population-Based Cancer Screening. Healthc Q 2014; 17(SP): 16−22.
McNamara D, Qasim A, Lee N, Condon C, O'Morain C. Round one of the Adelaide and Meath Hospital/Trinity College Colo-rectal Cancer Screening Programme: programme report and analysis based on established international key performance indices. Ir J Med Sci 2011; 180(2): 549−52.
Leuraud K, Jezewski-Serra D, Viguier J, Salines E. Colorectal can-cer screening by guaiac faecal occult blood test in France: Evaluation of the programme two years after launching. Can-cer Epidemiol 2013; 37(6): 959−67.
Faivre J, Hamza S. Organised screening for colorectal cancer: current position and futureprospects. Oncologie 2010; 12(10): 579−83.
Choi KS, Lee H, Jun JK, Shin A, Park E. Adherence to follow-up after a positive fecal occult blood test in an organized colo-rectal cancer screening program in Korea, 2004-2008. J Ga-stroenterol Hepatol 2012; 27(6): 1070−7.
Katičić M, Antoljak N, Kujundžić M, Stamenić V, Skoko Poljak D, Kramarić D, et al. Results of National Colorectal Cancer Screening Program in Croatia (2007-2011). World J Gastroen-terol 2012; 18(32): 4300−7.
Benson VS, Atkin WS, Green J, Nadel MR, Patnick J, Smith RA, et al. Toward standardizing and reporting colorectal cancer screening indicators on an international level: The international colorectal cancer screening network. Int J Cancer 2011; 130(12): 2961−73.
Segnan N, Senore C, Andreoni B, Azzoni A, Bisanti L, Cardelli A, et al. Comparing Attendance and Detection Rate of Colonos-copy With Sigmoidoscopy and FIT for Colorectal Cancer Screening. Gastroenterology 2007; 132(7): 2304−12.
Major D, Bryant H, Delaney M, Fekete S, Gentile L, Harrison M, et al. Colorectal cancer screening in Canada: results from the first round of screening for five provincial programs. Curr Oncol 2013; 20(5): 252−7.
Logan RF, Patnick J, Nickerson C, Coleman L, Rutter MD, von Wagner C. Outcomes of the Bowel Cancer Screening Pro-gramme (BCSP) in England after the first 1 million tests. Gut 2012; 61(10): 1439−46.