Promene linearnih i nelinearnih mera nizova RR i QT intervala posle uzimanja piva

  • Mirjana M Platiša University of Belgrade, Faculty of Medicine, Institute of Biophysics, ‡Institute of Pharmacology, Clinical Pharmacology and Toxicology
  • Vera Gal University of Belgrade, Faculty of Medicine, Institute of Biophysics, ‡Institute of Pharmacology, Clinical Pharmacology and Toxicology
  • Zorica Nestorović University of Belgrade, Faculty of Medicine, Institute of Biophysics, ‡Institute of Pharmacology, Clinical Pharmacology and Toxicology
  • Ida Leskošek-Čukalović Faculty of Agriculture, Department of Food Technology and Biochemistry, Belgrade, Serbia
  • Saša Despotović Faculty of Agriculture, Department of Food Technology and Biochemistry, Belgrade, Serbia
  • Mile Veljović Faculty of Agriculture, Department of Food Technology and Biochemistry, Belgrade, Serbia
  • Aleksandar Petrović Faculty of Agriculture, Department of Food Technology and Biochemistry, Belgrade, Serbia
  • Jovana Rajković Faculty of Agriculture, Department of Food Technology and Biochemistry, Belgrade, Serbia
  • Vladimir Đokić University of Belgrade, Faculty of Medicine, Institute of Pharmacology, Clinical Pharmacology and Toxicology
  • Radmila Novaković University of Belgrade, Faculty of Medicine, Institute of Pharmacology, Clinical Pharmacology and Toxicology
  • Ljiljana Gojković-Bukarica University of Belgrade, Faculty of Medicine, Institute of Pharmacology, Clinical Pharmacology and Toxicology
DOI: https://doi.org/10.2298/VSP150514316P
Ključne reči: alcohol drinking||, ||alkohol, pijenje, beer||, ||pivo, heart rate||, ||srce, frekvencija, electrocardiography||, ||elektrokardiografija, adult||, ||odrasle osobe,

Sažetak


Uvod/Cilj. Akutni efekat uzimanja alkoholnih pića na kardiovaskularne ritmove je fenomen koji još uvek nije dovoljno razjašnjen i u literaturi postoji svega nekoliko radova na tu temu. Cilj rada je bio da se ispita da li se linearnim i nelinearnim merama nizova RR i QT intervala može kvantifikovati akutni efekat male količine piva kod zdravih osoba. Metode. Osamnaest mladih zdravih muškaraca je pilo po 500 mL piva (21 g etanola). Elektrokardiogram (EKG) je beležen u ležećem položaju: 20 minuta pre (u relaksaciji) i 60 minuta neposredno posle uzimanja pića. Iz digitalizovanog zapisa EKG-a izdvojeni su nizovi RR i QT intervala. Iz oba niza smo izračunali kratkodometni (α1) i dugo-dometni skalirajući eksponent (α2), kao i entropiju uzorka (SampEn). Iz nizova RR intervala određene su spektralne komponente niskofrekventnih (LF) i visokofrekventnih (HF) opsega, a iz nizova QT intervala varijabilnost QT intervala (QTV). Krvni pritisak je bio meren svakih 10 minuta. Rezultati. Pokazali smo da pivo menja varijabilnost i korelacione osobine ovih nizova. Neposredni efekat uzimanja piva ogleda se u prolaznim povećanjima QT varijabilnosti, srčane frekvence i krvnog pritiska, a  produženi  u skraćenju dužine RR i QT intervala i smanjenju spektralne komponente HF. Uzimanje piva je takođe dovelo do porasta kratkodometnog skalirajućeg eksponenta (α1) RR niza i dugodometnog skalirajućeg eksponenta (α2) QT niza. Zaključak. Akutni efekat uzimanja piva je redukovana parasimpatička kontrola srca i izmenjena kompleksnost dinamike ventrikularne repolarizacije.

Biografija autora

Mirjana M Platiša, University of Belgrade, Faculty of Medicine, Institute of Biophysics, ‡Institute of Pharmacology, Clinical Pharmacology and Toxicology
Department of Pharmacology, Clinical Pharmacology and Toxicology

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Objavljeno
2018/08/23
Broj časopisa
Vol. 74 Br. 12 (2017)
Rubrika
Originalni članak