Prognostička vrednost paratireoidnog hormona u serumu kod bolesnika sa infarktom miokarda sa elevacijom ST segmenta

  • Slobodan Obradović Clinic for Emergency and Internal Medicine, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia
  • Snježana Vukotić Clinic for Emergency and Internal Medicine, Military Medical Academy, Belgrade, Serbia
  • Marko Banović Department of Cardiology, University Clinical Center of Serbia, Belgrade, Serbia
  • Boris Džudović Clinic for Emergency and Internal Medicine, Military Medical Academy, Belgrade, Serbia
  • Jelena Marinković Institute of Medical Statistics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Svetlana Vujanić Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia
  • Dragana Obradović Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia; Clinic of Neurology, Military Medical Academy, Belgrade, Serbia
DOI: https://doi.org/10.2298/VSP150816108O
Ključne reči: myocardial infarction||, ||infarkt miokarda, heart failure||, ||srce, insuficijencija, biological markers||, ||biološki pokazatelji, parathyroid hormone||, ||paratireoidni hormoni, natriuretic peptides||, ||natriuretski peptidi, creatine kinase||, ||kreatin kinaza, c-reactive protein||, ||c-reaktivni protein, blood glucose||, ||glikemija, sensitivity and specificity||, ||osetljivost i specifičnost,

Sažetak


Uvod/Cilj. Paratireoidni hormon (PTH) značajan je glasnik u regeneracionim procesima i može uticati na ishod kod bolesnika sa infarktom miokarda sa ST elevacijom (STEMI). Cilj ovog rada bio je da se ispita uloga PTH u poređenju sa drugim uobičajenim markerima za predviđanje srčane slabosti kod bolesnika sa STEMI. Metode. Kod 165 bolesnika sa STEMI, lečenih primarnom perkutanom koronarnom intervencijom, prva tri dana hospitalizacije merene su vrednosti u serumu: PTH, B-tipa natriuretskog peptida (BNP), kreatin-kinaze miokarda (CK-MB), C-reaktivnog proteina (CRP) i glikemije na prijemu, te je ispitivan uticaj na primarni ishod – epizode akutne srčane slabosti u periodu od šest meseci. Rezultati. Površina ispod ROC krive bila je najveća u poređenju sa ostalim markerima (0,867 vs 0,835 vs 0,832 vs 0,627 vs 0,619), za PTH, CRP, BNP, CK-MB i glikemiju na prijemu za predviđanje primarnog ishoda. Maksimalna vrednost PTH imala je nezavisnu vrednost predviđanja za primarni ishod (p < 0,001). Zaključak. Serumske koncentracije PTH u ranoj fazi STEMI mogu predvideti epizode akutne srčane slabosti u prvih šest meseci kod bolesnika lečenih primarnom perkutanom koronarnom intervencijom.

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Objavljeno
2017/06/21
Broj časopisa
Vol. 74 Br. 3 (2017)
Rubrika
Originalni članak