Ispitivanje nivoa leptina i grelina u serumu gojazne, normalno uhranjene i mršave dece

Mirjana N Miljković; Ljiljana M Šaranac; Jelena Bašić; Mirjana Ilić; Boris Đinđić; Marija G Stojiljković; Gordana Kocić; Goran Z Cvetanović; Nebojša Dimitrijević

doi:10.2298/VSP151215151M

Mirjana N Miljković General Hospital Leskovac, Leskovac, Serbia
Ljiljana M Šaranac Clinical Centre Niš, Pediatric Clinic, Niš, Serbia; University of Niš, Faculty of Medicine, Niš, Serbia
Jelena Bašić University of Niš, Faculty of Medicine, Niš, Serbia
Mirjana Ilić Clinical Centre Niš, Pediatric Clinic, Niš, Serbia
Boris Đinđić University of Niš, Faculty of Medicine, Niš, Serbia
Marija G Stojiljković General Hospital Leskovac, Leskovac, Serbia
Gordana Kocić University of Niš, Faculty of Medicine, Niš, Serbia
Goran Z Cvetanović
Nebojša Dimitrijević General Hospital Leskovac, Leskovac, Serbia

DOI: https://doi.org/10.2298/VSP151215151M

Ključne reči: nutritional status||, ||uhranjenost, child||, ||deca, leptin||, ||leptin, ghrelin||, ||grelin, obesity||, ||gojaznost,

Sažetak

Uvod/Cilj. Homeostaza energije je balans između energetskog unosa i potrošnje energije. Leptin i grelin su dva oreksitropna hormona sa suprotnim efektom na homeostazu energije. Ispitivane su vrednosti leptina i grelina u serumu dece različititog tipa uhranjenosti. Metode. Kod 30 gojazne dece oba pola, uzrasta od 6 do 17,67 godina (srednja vrednost 13,04 ± 2,95 godine), određivane su vrednosti leptina i grelina u serumu, uz određivanje auksoloških parametara i pubertetskog statusa. Dobijeni rezultati su analizirani i upoređivani sa vrednostima istih parametara kod 33 normalno uhranjene i 25 mršave dece. Rezultati. Vrednosti odnosa grelin/telesna masa (TM) bile su najniže kod gojazne dece (21,75 ± 12,60 pg/mL/kg) što je statistički značajno različito u odnosu na vrednosti kod mršave i normalno ishranjene dece. Vrednost odnosa leptin/TM bila je statistički značajno veća kod gojazne dece (0.62 ± 0.86) u odnosu na normalno uhranjene (p < 0,01) i mršave (p < 0,001). Vrednosti leptina i grelina pokazale su različit profil kod gojazne, normalno uhranjene i mršave dece. U ispitivanim grupama dokazane su inverzne vrednosti odnosa grelin/leptin i leptin/grelin. Zaključak. Gojazna deca imaju značajno više vrednosti leptina, a mršava deca značajno više vrednosti grelina po kilogramu telesne mase u odnosu na ostalu decu. Rezultati ukazuju i na inverzni odnos grelina i leptina koji se pokazao kao klinički pouzdan pokazatelj prisustva gojaznosti ili neuhranjenosti kod dece, što je od velikog značaja, uzimajući u obzir velike varijacije u koncentraciji ovih hormona, ne samo prema telesnoj masi, već i prema uzrastu dece.

Biografije autora

Mirjana N Miljković, General Hospital Leskovac, Leskovac, Serbia

Prim. dr med. spec. pedijatrije

Ljiljana M Šaranac, Clinical Centre Niš, Pediatric Clinic, Niš, Serbia; University of Niš, Faculty of Medicine, Niš, Serbia

Prof.dr med. sci.spec.pedijatrije, subspec. endokrinologije

Jelena Bašić, University of Niš, Faculty of Medicine, Niš, Serbia

doc.dr sci. med. spec biohemije

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