Monocyte/HDL-cholesterol ratio as an early prognostic marker of pregnancy complications development

Jovana Vulić; Jelena Radojković; Jelena Vekić; Aleksandra Stefanović; Daniela Ardalić; Željko Miković; Tamara Gojković; Jelena Munjas; Aleksandra Zeljkovic

doi:10.5937/arhfarm75-54675

Jovana Vulić University of Belgrade - Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Jelena Radojković University of Belgrade - Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Jelena Vekić University of Belgrade - Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Aleksandra Stefanović University of Belgrade - Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Daniela Ardalić Gynecology and Obstetrics Clinic Narodni Front, Belgrade, Serbia
Željko Miković Clinic for Gynecology and Obstetrics Narodni Front, Belgrade, Serbia; University of Belgrade - Faculty of Medicine, Belgrade, Serbia
Tamara Gojković University of Belgrade - Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Jelena Munjas University of Belgrade - Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Aleksandra Zeljkovic University of Belgrade - Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia

DOI: https://doi.org/10.5937/arhfarm75-54675

Keywords: pregnancy, complications, monocyte/HDL-C ratio

Abstract

Pregnancy complications increase the long-term cardiovascular risk for both the mother and the child. Inflammation is a common mechanism underlying the development of pregnancy complications and atherosclerosis. This study aims to investigate whether the monocyte/HDL cholesterol ratio can serve as a predictive marker for the risk of pregnancy complications. A total of 84 pregnant women participated in this study, 41 of whom had a normal pregnancy course, while 43 experienced complications. Lipid status parameters were measured using enzymatic methods and total blood count was measured using a hematology analyzer. In the first trimester of pregnancies with complications we observed significantly higher levels of total cholesterol (P < 0.01), low-density lipoprotein cholesterol (LDL-C) (P < 0.01) and triglycerides (P < 0.001) compared to pregnancies without complications, whereas no differences were observed in high-density lipoprotein cholesterol (HDL-C). Pregnant women with complications had a significantly higher proportion of monocytes throughout the entire pregnancy, and lower concentrations of HDL-C in the second trimester (P < 0.05). The risk of developing complications in pregnancy was 11 times higher if the monocyte/HDL-C ratio was elevated in the first trimester (OR: 11.42; 95%CI: 4.05–32.19; P < 0.001). Our results indicate that monocyte/HDL-C ratio could be used as a simple and cost-effective early prognostic biomarker of pregnancy complications.

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