Odnos monociti/HDL-holesterol kao rani prognostički marker razvoja komplikacija u trudnoći

  • Jovana Vulić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za medicinsku biohemiju, Beograd, Srbija
  • Jelena Radojković Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za medicinsku biohemiju, Beograd, Srbija
  • Jelena Vekić Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za medicinsku biohemiju, Beograd, Srbija
  • Aleksandra Stefanović Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za medicinsku biohemiju, Beograd, Srbija
  • Daniela Ardalić Ginekološko-akušerska klinika Narodni Front, Beograd, Srbija
  • Željko Miković Ginekološko-akušerska klinika Narodni Front, Beograd, Srbija; Univerzitet u Beogradu- Medicinski fakultet, Beograd, Srbija
  • Tamara Gojković Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za medicinsku biohemiju, Beograd, Srbija
  • Jelena Munjas Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za medicinsku biohemiju, Beograd, Srbija
  • Aleksandra Zeljkovic Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za medicinsku biohemiju, Beograd, Srbija
DOI: https://doi.org/10.5937/arhfarm75-54675
Ključne reči: trudnoća, komplikacije, odnos monociti/HDL-h

Sažetak


Komplikacije u trudnoći povećavaju rizik za razvoj kardiovaskularnih oboljenja u kasnijem životu majke i deteta. Inflamacija je zajednički mehanizam koji se nalazi u osnovi razvoja komplikacija u trudnoći i ateroskleroze. Cilj rada je bio da se ispita da li se na osnovu odnosa monociti/HDL-holesterol može predvideti rizik za razvoj komplikacija u trudnoći. U istraživanju su učestvovale 84 trudnice, od kojih je 41 imala urednu trudnoću, a 43 trudnoću sa komplikacijama. Parametri lipidnog statusa su određeni enzimskim metodama, a broj i udeo leukocita na hematološkom analizatoru. Tokom prvog trimestra trudnoće sa komplikacijama bile su uočene značajno više koncentracije ukupnog holesterola (P < 0,01), holesterola u česticama lipoproteina niske gustine (LDL-h) (P < 0,01) i triglicerida (P < 0,001) nego u trudnoći bez komplikacija, dok razlike u koncentraciji holesterola u česticama lipoproteina visoke gustine (HDL-h) nisu bile značajne. Trudnice sa komplikacijama su imale značajno viši udeo monocita tokom cele trudnoće, a niže koncentracije HDL-h u drugom trimestru (P < 0,05). Utvrdili smo da je verovatnoća za razvoj komplikacija u trudnoći oko 11 puta veća ukoliko je u prvom trimestru odnos monociti/HDL-h povišen (OR: 11,42; 95%CI: 4,05–32,19; P < 0,001). Naši rezultati ukazuju da bi se odnos monociti/HDL-h mogao koristiti kao jednostavan i ekonomičan rani prognostički biomarker razvoja komplikacija u trudnoći.

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Objavljeno
2025/02/23
Broj časopisa
Vol. 75 Br. Notebook 1 (2025): Arhiv za farmaciju
Rubrika
Originalni naučni rad
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