Pharmacoeconomic evaluation of antimicrobial wound dressings in the treatment of venous leg ulcers

Dragana Dimitrić; Nataša Bogavac Stanojević; Dušanka Krajnović; Dragana Lakić

doi:10.5937/arhfarm75-59726

Dragana Dimitrić University of Belgrade – Faculty of Pharmacy, Department for Social Pharmacy and Pharmaceutical Legislation, Belgrade, Serbia
Nataša Bogavac Stanojević University of Belgrade - Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Dušanka Krajnović University of Belgrade – Faculty of Pharmacy, Department for Social Pharmacy and Pharmaceutical Legislation, Belgrade, Serbia
Dragana Lakić University of Belgrade – Faculty of Pharmacy, Department for Social Pharmacy and Pharmaceutical Legislation, Belgrade, Serbia

DOI: https://doi.org/10.5937/arhfarm75-59726

Keywords: dressing, economic evaluation, venous leg ulcer, cost-effectiveness

Abstract

Venous leg ulcers (VLUs) account for most lower extremity wounds. Wound management include cleansing, debridement, infection control and applying wound dressing. There exist various types of dressings which can maintain adequate moisture, offer protection, and support the reepithelization of VLUs. The aim of this study is to evaluate the cost-effectiveness of the antimicrobial wound dressing containing ionic silver (Aquacel^Ò Ag+Extra^TM) in the treatment of VLUs compared to conventional gauze dressing in Serbia. The data regarding the effectiveness and frequency of dressings for both the Aquacel^Ò Ag+Extra^TM and conventional dressing were obtained from literature sources. Only direct costs were considered, and values were taken from the published price list of health services or procurement procedures. Sensitivity analyses were performed.  The total cost per patient for Aquacel^Ò Ag+Extra^TM was 34,178.76 RSD, while the total cost for gauze was 82,800.90 RSD. Besides lower costs, antimicrobial wound dressing shows higher effectiveness than the gauze, implying that Aquacel^Ò Ag+Extra^TM is the dominant strategy. The sensitivity analysis supports the robustness of the results.  The use of antimicrobial wound dressing containing ionic silver is the preferred option for the treatment of VLUs due to lower costs and the higher curing rate of the wounds.

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