Efekat imunizacije vakcinom protiv gripa na prirodna antitela

  • Irena Živković Institut za virusologiju, vakcine i serume - Torlak
  • Lina Muhandes Institut za virusologiju, vakcine i serume - Torlak
  • Vladimir Petrušić Institut za virusologiju, vakcine i serume- Torlak
  • Rajna Minić Institut za virusologiju, vakcine i serume- Torlak
  • Ljiljana Dimitrijević Institut za virusologiju, vakcine i serume- Torlak
DOI: https://doi.org/10.5937/arhfarm71-30800
Ključne reči: Prirodna antitela, imunizacija, imunološka homeostaza

Sažetak


Prirodna, polireaktivna i slabo afinitetna antitela igraju važnu ulogu ne samo u neposrednoj odbrani od patogena, već i u oblikovanju stečenog imunskog odgovora. S druge strane, indukcija visoko afinitetnih, antigen - specifičnih antitela, može uticati na ravnotežu prirodnih antitela i time dovesti do autoimunskih bolesti. U ovoj studiji analizirali smo da li imunizacija ljudi split ili celovirusnom vakcinom protiv gripa može dovesti do promena u IgM i IgG pulu prirodnih antitela. Za analizu su korišćeni “in-house” razvijeni ELISA testovi. Ispitanici su podeljeni prema vakcinalnom statusu na one koji su prethodnih godina bili imunizovani vakcinom protiv gripa i one koji su prvi put imunizovani. Pokazano je da imunizacijom nije narušen ukupan pul prirodnih antitela ni u jednoj grupi i da je došlo do određenih fluktuacija u nivoima prirodnih antitela kako bi se održala homeostaza imunskog sistema.

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Objavljeno
2021/06/07
Broj časopisa
Vol. 71 Br. Notebook 3 (2021): Arhiv za farmaciju
Rubrika
Originalni naučni rad
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