Endocrine disruption by PFAS: a major concern associated with legacy and replacement substances
Sažetak
Zahvaljujući svojim izuzetnim svojstvima, raznovrsnoj primeni i hemijskoj stabilnosti, per- i poli-fluoralkil supstance (PFAS) se decenijama koriste u najrazličitijim procesima i proizvodima. Međutim, sve se više govori o tome da ove supstance mogu predstavljati ozbiljnu pretnju po zdravlje ljudi i živih organizama usled svoje postojanosti, sposobnosti prenošenja na velikim udaljenostima i tendencije da se akumuliraju u živim organizmima. Iz ovog razloga, širom EU činjeni su određeni napori da se identifikuju alternativni molekuli, kraćeg ugljeničnog lanca i teoretski bezbednijeg profila, koji bi mogli da zamene prethodnu generaciju tradicionalnih PFAS supstanci. Nažalost, ova strategija nije bila u potpunosti uspešna, te PFAS supstance i dalje predstavljaju ozbiljan razlog za zabrinutost. Između ostalog, jedan od aspekata koji dobija na značaju su i štetni efekti koje i tradicionalne i alternativne PFAS supstance mogu imati na endokrini sistem, naročito kod osetljivih podgrupa stanovništva. U ovom preglednom radu je dat kratak rezime svojstava PFAS supstanci, njihove upotrebe i sudbine u životnoj sredini, sa fokusom na njihovo dejstvo na reproduktivnu sposobnost i plodnost ljudi, metabolizam i gojaznost, kao i na tiroidnu funkciju.
Reference
De Silva AO, Armitage JM, Bruton TA, Dassuncao C, Heiger-Bernays W, Hu XC, et al. PFAS Exposure Pathways for Humans and Wildlife: A Synthesis of Current Knowledge and Key Gaps in Understanding. Environ Toxicol Chem. 2021;40:631-57.
Ankley GT, Cureton P, Hoke RA, Houde M, Kumar A, Kurias J, et al. Assessing the Ecological Risks of Per- and Polyfluoroalkyl Substances: Current State-of-the Science and a Proposed Path Forward. Environ Toxicol Chem. 2021;40:564-605.
Lindstrom AB, Strynar MJ, Libelo EL. Polyfluorinated compounds: past, present, and future. Environ Sci Technol. 2011;45:7954-61.
Gluge J, Scheringer M, Cousins IT, DeWitt JC, Goldenman G, Herzke D, et al. An overview of the uses of per- and polyfluoroalkyl substances (PFAS). Environ Sci Process Impacts. 2020;22:2345-73.
Wang W, Rhodes G, Ge J, Yu X, Li H. Uptake and accumulation of per- and polyfluoroalkyl substances in plants. Chemosphere. 2020;261:127584.
Koch A, Jonsson M, Yeung LWY, Karrman A, Ahrens L, Ekblad A, et al. Per- and Polyfluoroalkyl-Contaminated Freshwater Impacts Adjacent Riparian Food Webs. Environ Sci Technol. 2020;54:11951-60.
Tsuda S. Differential toxicity between perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). J Toxicol Sci. 2016;41:SP27-SP36.
Kang H, Choi K, Lee HS, Kim DH, Park NY, Kim S, et al. Elevated levels of short carbon-chain PFCAs in breast milk among Korean women: Current status and potential challenges. Environ Res. 2016;148:351-9.
Nian M, Luo K, Luo F, Aimuzi R, Huo X, Chen Q, et al. Association between Prenatal Exposure to PFAS and Fetal Sex Hormones: Are the Short-Chain PFAS Safer? Environ Sci Technol. 2020:54;8291-9.
Tsai MS, Chang SH, Kuo WH, Kuo CH, Li SY, Wang MY, et al. A case-control study of perfluoroalkyl substances and the risk of breast cancer in Taiwanese women. Environ Int. 2020;142,105850
Mancini FR, Cano-Sancho G, Gambaretti J, Marchand P, Boutron-Ruault MC, Severi G, et al. Perfluorinated alkylated substances serum concentration and breast cancer risk: Evidence from a nested case-control study in the French E3N cohort. Int J Cancer. 2020;146:917-28.
Beans C. News Feature: How "forever chemicals" might impair the immune system. Proc Natl Acad Sci U S A. 2021;118: 1-5
Xu Y, Jurkovic-Mlakar S, Lindh CH, Scott K, Fletcher T, Jakobsson K, et al. Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden. Environ Int. 2020;145: 106148
Kim S, Stroski KM, Killeen G, Smitherman C, Simcik MF, Brooks BW. 8:8 Perfluoroalkyl phosphinic acid affects neurobehavioral development, thyroid disruption, and DNA methylation in developing zebrafish. Sci Total Environ. 2020;736:139600
DeWitt JC, Blossom SJ, Schaider, L. A. Exposure to per-fluoroalkyl and polyfluoroalkyl substances leads to immunotoxicity: epidemiological and toxicological evidence. J Expo Sci Environ Epidemiol. 2019;29:148-56.
Kabir ER, Rahman MS, Rahman I. A review on endocrine disruptors and their possible impacts on human health. Environ Toxicol Pharmacol. 2015;40:241-58.
Sonthithai P, Suriyo T, Thiantanawat A, Watcharasit P, Ruchirawat M, Satayavivad J. Perfluorinated chemicals, PFOS and PFOA, enhance the estrogenic effects of 17beta-estradiol in T47D human breast cancer cells. J Appl Toxicol. 2016;36:790-801.
Du G, Hu J, Huang H, Qin Y, Han X, Wu D, et al. Perfluorooctane sulfonate (PFOS) affects hormone receptor activity, steroidogenesis, and expression of endocrine-related genes in vitro and in vivo. Environ Toxicol Chem. 2013;32:353-360.
Yu WG, Liu W, Jin YH. Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism. Environ Toxicol Chem. 2009;28:990-6.
Mitro SD, Sagiv SK, Fleisch AF, Jaacks LM, Williams PL, Rifas-Shiman SL, et al. Pregnancy Per- and Polyfluoroalkyl Substance Concentrations and Postpartum Health in Project Viva: A Prospective Cohort. J Clin Endocrinol Metab. 2020;105: 3415-3426.
Gardener H, Sun Q, Grandjean P. PFAS concentration during pregnancy in relation to cardiometabolic health and birth outcomes. Environ Res. 2021;192:110287.
Rylander L, Lindh CH, Hansson SR, Broberg K, Kallen K. Per- and Polyfluoroalkyl Substances in Early Pregnancy and Risk for Preeclampsia: A Case-Control Study in Southern Sweden. Toxics. 2020;8: 1-9.
Manea S, Salmaso L, Lorenzoni G, Mazzucato M, Russo F, Mantoan D, et al. Exposure to PFAS and small for gestational age new-borns: A birth records study in Veneto Region (Italy). Environ Res. 2020;184:109282
Anderko L, Pennea E. Exposures to per-and polyfluoroalkyl substances (PFAS): Potential risks to reproductive and children's health. Curr Probl Pediatr Adolesc Health Care. 2020;50:100760
Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, de Voogt P, et al. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag. 2011;7:513-41.
Nickerson A, Rodowa AE, Adamson DT, Field JA, Kulkarni PR, Kornuc JJ, et al. Spatial Trends of Anionic, Zwitterionic, and Cationic PFASs at an AFFF-Impacted Site. Environ Sci Technol. 2021;55:313-23.
Brase RA, Mullin EJ, Spink DC. Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects. Int J Mol Sci. 2021;22: 1-30.
Barzen-Hanson KA, Roberts SC, Choyke S, Oetjen K, McAlees A, Riddell N, et al. Discovery of 40 Classes of Per- and Polyfluoroalkyl Substances in Historical Aqueous Film-Forming Foams (AFFFs) and AFFF-Impacted Groundwater. Environ Sci Technol. 2017;51:2047-57.
Rayne S, Forest K. Perfluoroalkyl sulfonic and carboxylic acids: a critical review of physicochemical properties, levels and patterns in waters and wastewaters, and treatment methods. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2009;44:1145-99.
Cousins IT, DeWitt JC, Gluge J, Goldenman G, Herzke D, Lohmann R, et al. The high persistence of PFAS is sufficient for their management as a chemical class. Environ Sci Process Impacts. 2020;22:2307-12.
Higgins, CP, McLeod PB, MacManus-Spencer LA, Luthy RG. Bioaccumulation of perfluorochemicals in sediments by the aquatic oligochaete Lumbriculus variegatus. Environ Sci Technol. 2007;41:4600-6.
Kannan K, Tao L, Sinclair E, Pastva SD, Jude DJ, Giesy JP. Perfluorinated compounds in aquatic organisms at various trophic levels in a Great Lakes food chain. Arch Environ Contam Toxicol. 2005;48,559-66.
Olsen GW, Church TR, Miller JP, Burris JM, Hansen KJ, Lundberg JK, et al. Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors. Environ Health Perspect. 2003;111:1892-901.
Kannan K, Corsolini S, Falandysz J, Fillmann G, Kumar KS, Loganathan BG, et al. Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries. Environ Sci Technol. 2004;38:4489-95.
Yamashita N, Kannan K, Taniyasu S, Horii Y, Petrick G, Gamo T. A global survey of perfluorinated acids in oceans. Mar Pollut Bull. 2005;51:658-68.
Higgins CP, Field JA, Criddle CS, Luthy RG. Quantitative determination of perfluorochemicals in sediments and domestic sludge. Environ Sci Technol. 2005;39:3946-56.
Bossi R, Riget FF, Dietz R, Sonne C, Fauser P, Dam M, et al. Preliminary screening of perfluorooctane sulfonate (PFOS) and other fluorochemicals in fish, birds and marine mammals from Greenland and the Faroe Islands. Environ Pollut. 2005;136:323-39.
History and Use of Per- and Polyfluoroalkyl Substances (PFAS), 2020.
Sunderland EM, Hu XC, Dassuncao C, Tokranov AK, Wagner CC, Allen JG. A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects. J Expo Sci Environ Epidemiol. 2019;29:131-47.
Abunada Z, Alazaiza MYD, Bashir MJK. An Overview of Per- and Polyfluoroalkyl Substances (PFAS) in the Environment: Source, Fate, Risk and Regulations. Water. 2020;12:3590
Shi Y, Vestergren R, Xu L, Song X, Niu X, Zhang C, et al. Characterizing direct emissions of perfluoroalkyl substances from ongoing fluoropolymer production sources: A spatial trend study of Xiaoqing River, China. Environmental Pollution. 2015;206:104-12.
Bach C, Dauchy X, Boiteux V, Colin A, Hemard J, Sagres V, et al. The impact of two fluoropolymer manufacturing facilities on downstream contamination of a river and drinking water resources with per- and polyfluoroalkyl substances. Environ Sci Pollut Res Int. 2017;24:4916-25.
Semerad J, Hatasova N, Grasserova A, Cerna T, Filipova A, Hanc A, et al. Screening for 32 per- and polyfluoroalkyl substances (PFAS) including GenX in sludges from 43 WWTPs located in the Czech Republic - Evaluation of potential accumulation in vegetables after application of biosolids. Chemosphere. 2020;261:128018
Venkatesan AK, Halden RU. National inventory of perfluoroalkyl substances in archived U.S. biosolids from the 2001 EPA National Sewage Sludge Survey. J Hazard Mater. 2013;252-253:413-8.
Meegoda JN, Kewalramani JA, Li B, Marsh RW. A Review of the Applications, Environmental Release, and Remediation Technologies of Per- and Polyfluoroalkyl Substances. Int J Environ Res Public Health. 2020;17: 1-26.
Stoiber T, Evans S, Naidenko OV. Disposal of products and materials containing per- and polyfluoroalkyl substances (PFAS): A cyclical problem. Chemosphere. 2020;260:127659.
Nguyen TMH, Braunig J, Thompson K, Thompson J, Kabiri S, Navarro DA, et al. Influences of Chemical Properties, Soil Properties, and Solution pH on Soil-Water Partitioning Coefficients of Per- and Polyfluoroalkyl Substances (PFASs). Environ Sci Technol. 2020;54:15883-92.
Hoisaeter A, Pfaff A, Breedveld GD. Leaching and transport of PFAS from aqueous film-forming foam (AFFF) in the unsaturated soil at a firefighting training facility under cold climatic conditions. J Contam Hydrol. 2019;222:112-22.
Le ST, Kibbey TCG, Weber KP, Glamore WC, O'Carroll DM. A group-contribution model for predicting the physicochemical behavior of PFAS components for understanding environmental fate. Sci Total Environ. 2021;764:142882.
Casas G, Martinez-Varela A, Roscales JL, Vila-Costa M, Dachs J, Jimenez B. Enrichment of perfluoroalkyl substances in the sea-surface microlayer and sea-spray aerosols in the Southern Ocean. Environ Pollut. 2020;267:115512.
Mussabek D, Ahrens L, Persson KM, Berndtsson R. Temporal trends and sediment-water partitioning of per- and polyfluoroalkyl substances (PFAS) in lake sediment. 2019;227:624-9.
Liu Y, Zhang Y, Li J, Wu N, Li W, Niu Z. Distribution, partitioning behavior and positive matrix factorization-based source analysis of legacy and emerging polyfluorinated alkyl substances in the dissolved phase, surface sediment and suspended particulate matter around coastal areas of Bohai Bay, China. Environ Pollut. 2019;246:34-44.
Dimzon IK, Westerveld J, Gremmel C, Fromel T, Knepper TP, de Voogt P. Sampling and simultaneous determination of volatile per- and polyfluoroalkyl substances in wastewater treatment plant air and water. Anal Bioanal Chem. 2017;409:1395-404.
Schroeder T, Bond D, Foley J. PFAS soil and groundwater contamination via industrial airborne emission and land deposition in SW Vermont and Eastern New York State, USA. Environ Sci Process Impacts. 2021;23:291-301.
Sharifan H, Bagheri M, Wang D, Burken JG, Higgins CP, Liang Y, et al. Fate and transport of per- and polyfluoroalkyl substances (PFASs) in the vadose zone. Sci Total Environ. 2021;771:145427.
Shin HM, Vieira VM, Ryan PB, Detwiler R, Sanders B, Steenland K, et al. Environmental fate and transport modeling for perfluorooctanoic acid emitted from the Washington Works Facility in West Virginia. Environ Sci Technol. 2011;45:1435-42.
Hunter Anderson R, Adamson DT, Stroo HF. Partitioning of poly- and perfluoroalkyl substances from soil to groundwater within aqueous film-forming foam source zones. J Contam Hydrol. 2019;220:59-65.
Skaar JS, Raeder EM, Lyche JL, Ahrens L, Kallenborn R. Elucidation of contamination sources for poly- and perfluoroalkyl substances (PFASs) on Svalbard (Norwegian Arctic). Environ Sci Pollut Res Int. 2019;26:7356-63.
Knutsen H, Maehlum T, Haarstad K, Slinde GA, Arp HPH. Leachate emissions of short- and long-chain per- and polyfluoralkyl substances (PFASs) from various Norwegian landfills. Environ Sci Process Impacts. 2019;21:1970-9.
Lenka, SP, Kah M, Padhye LP. A review of the occurrence, transformation, and removal of poly- and perfluoroalkyl substances (PFAS) in wastewater treatment plants. Water Res. 2021;199:117187.
Li R, Munoz G, Liu Y, Sauve S, Ghoshal S, Liu J. Transformation of novel polyfluoroalkyl substances (PFASs) as co-contaminants during biopile remediation of petroleum hydrocarbons. J Hazard Mater. 2019;362:140-7.
Ellis DA, Martin JW, De Silva AO, Mabury SA, Hurley MD, Sulbaek Andersen MP, et al. Degradation of fluorotelomer alcohols: a likely atmospheric source of perfluorinated carboxylic acids. Environ Sci Technol. 2004;38:3316-21.
Zhang H, Wang SL, Yu Y. [Concentrations of Typical Perfluoroalkyl Acids and Contributions of Their Precursors in the Water of the Le'an River in China]. Huan Jing Ke Xue. 2020;41,3204-11.
Butt CM, Muir DC, Mabury SA. Biotransformation pathways of fluorotelomer-based polyfluoroalkyl substances: a review. Environ Toxicol Chem. 2014;33:243-67.
Langberg HA, Breedveld GD, Slinde GA, Gronning HM, Hoisaeter A, Jartun M, et al. Fluorinated Precursor Compounds in Sediments as a Source of Perfluorinated Alkyl Acids (PFAA) to Biota. Environ Sci Technol. 2020;54:13077-89.
3M [Internet]. Phase-out plan for PSOF based compounds, 2020.Available from: https://archive.epa.gov/epapages/newsroom_archive/newsreleases/33aa946e6cb11f35852568e1005246b4.html.>
US-EPA [Internet]. Fact Sheet: 2010/2015 PFOA Stewardship Program, 2020.Avaliable from: https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/fact-sheet-20102015-pfoa-stewardship-program.>
EP-CEU [Internet]. REGULATION (EU) 2019/1021 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 20 June 2019 on persistent organic pollutants. Official Journal of the European Union, 2019. Available from: https://eur-lex.europa.eu/eli/reg/2019/1021/oj.>
EP-CEU [Internet]. Amending Annex I to Regulation (EU) 2019/1021 of the European Parliament and of the Council as regards the entry for perfluorooctane sulfonic acid and its derivatives (PFOS). Official Journal of the European Union, 2020. Available from: https://eur-lex.europa.eu/eli/reg_del/2020/1203/oj.>
Chemicalwatch [Internet]. Global ban on PFOA enters into force for most countries, 2020. Available from: https://chemicalwatch.com/189390/global-ban-on-pfoa-enters-into-force-for-most-countries>
EP-CEU [Internet]. Amending Annex I to Regulation (EU) 2019/1021 of the European Parliament and of the Council as regards the listing of perfluorooctanoic acid (PFOA), its salts and PFOA-related compounds. Official Journal of the European Union, 2020. Available from: https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=pi_com%3AAres%282019%296890180.>
Poothong S, Papadopoulou E, Padilla-Sanchez JA, Thomsen C, Haug LS. Multiple pathways of human exposure to poly- and perfluoroalkyl substances (PFASs): From external exposure to human blood. Environ Int. 2020;134:105244.
Arinaitwe K, Keltsch N, Taabu-Munyaho A, Reemtsma T, Berger U. Perfluoroalkyl substances (PFASs) in the Ugandan waters of Lake Victoria: Spatial distribution, catchment release and public exposure risk via municipal water consumption. Sci Total Environ. 2021;783:146970.
Hansen S, Vestergren R, Herzke D, Melhus M, Evenset A, Hanssen L, et al. Exposure to per- and polyfluoroalkyl substances through the consumption of fish from lakes affected by aqueous film-forming foam emissions - A combined epidemiological and exposure modeling approach. The SAMINOR 2 Clinical Study. Environ Int. 2016;94:272-82.
Li N, Ying GG, Hong H, Deng WJ. Perfluoroalkyl substances in the urine and hair of preschool children, airborne particles in kindergartens, and drinking water in Hong Kong. Environ Pollut. 2021;270:116219.
Xu Y, Fletcher T, Pineda D, Lindh CH, Nilsson C, Glynn A, et al. Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam. Environ Health Perspect. 2020;128:77004.
Forsthuber M, Kaiser AM, Granitzer S, Hassl I, Hengstschlager M, Stangl H, et al. Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma. Environ Int. 2020;137:105324.
Kar S, Sepulveda MS, Roy K, Leszczynski J. Endocrine-disrupting activity of per- and polyfluoroalkyl substances: Exploring combined approaches of ligand and structure based modeling. Chemosphere. 2017;184:514-23.
Blake BE, Fenton SE. Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects. Toxicology. 2020;443:152565.
Khazaee M, Christie E, Cheng W, Michalsen M, Field J, Ng C. Perfluoroalkyl Acid Binding with Peroxisome Proliferator-Activated Receptors alpha, gamma, and delta, and Fatty Acid Binding Proteins by Equilibrium Dialysis with a Comparison of Methods. Toxics. 2021;9: 1-15.
Lai TT, Eken Y, Wilson AK. Binding of Per- and Polyfluoroalkyl Substances to the Human Pregnane X Receptor. Environ Sci Technol. 2020;54:15986-95.
Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek NE, Soto AM, et al. Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology. 2012;153:4097-110.
Serra H, Beausoleil C, Habert R, Minier C, Picard-Hagen N, Michel C. Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives. Environ Health Perspect. 2019;127:106001.
Boas M, Feldt-Rasmussen U, Main KM. Thyroid effects of endocrine disrupting chemicals. Mol Cell Endocrinol. 2012;355:240-8.
Nowak K, Jablonska E, Ratajczak-Wrona W. Immunomodulatory effects of synthetic endocrine disrupting chemicals on the development and functions of human immune cells. Environ Int. 2019;125:350-64.
Soundararajan A, Prabu P, Mohan V, Gibert Y, Balasubramanyam M. Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes. Mol Cell Biochem. 2019;458:171-83.
Sifakis S, Androutsopoulos VP, Tsatsakis AM, Spandidos DA. Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems. Environ Toxicol Pharmacol. 2017;51:56-70.
Olaniyan LWB, Okoh AI. Determination and ecological risk assessment of two endocrine disruptors from River Buffalo, South Africa. Environ Monit Assess. 2020;192:750.
Filipkowska A, Lubecki L. Endocrine disruptors in blue mussels and sediments from the Gulf of Gdansk (Southern Baltic). Environ Sci Pollut Res Int. 2016;23:13864-13876.
Fellowes R, Fortune F, Bergmeier LA, Lehner T. The effect of immunization with a 14-kDa streptococcal antigen on primate T cell and B cell responses. Eur J Immunol. 1988;18:559-64.
FitzGerald RE. Perspective on Health Effects of Endocrine Disruptors with a Focus on Data Gaps. Chem Res Toxicol. 2020;33:1284-91.
Yilmaz B, Terekeci H, Sandal S, Kelestimur F. Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention. Rev Endocr Metab Disord. 2020;21:127-47.
Cardenas A, Hauser R, Gold DR, Kleinman KP, Hivert MF, Fleisch AF, et al. Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Adiposity. JAMA Netw Open. 2018;1:e181493.
Rodriguez-Jorquera IA, Colli-Dula RC, Kroll K, Jayasinghe BS, Parachu Marco MV, Silva-Sanchez C, et al. Blood Transcriptomics Analysis of Fish Exposed to Perfluoro Alkyls Substances: Assessment of a Non-Lethal Sampling Technique for Advancing Aquatic Toxicology Research. Environ Sci Technol. 2019;53:1441-52.
Kovarich S, Papa E, Li J, Gramatica P. QSAR classification models for the screening of the endocrine-disrupting activity of perfluorinated compounds. SAR QSAR Environ Res. 2012;23:207-20.
Ren XM, Zhang YF, Guo LH, Qin ZF, Lv QY, Zhang LY. Structure-activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor. Arch Toxicol. 2015;89:233-42.
Pelch KE, Reade A, Wolffe TAM, Kwiatkowski CF. PFAS health effects database: Protocol for a systematic evidence map. Environ Int. 2019;130:104851.
(2021) The Endocrine Disruption Exchange [Internet]. Available from: https://endocrinedisruption.org.>
Chen L, Hu C, Tsui MMP, Wan T, Peterson DR, Shi Q, et al. Multigenerational Disruption of the Thyroid Endocrine System in Marine Medaka after a Life-Cycle Exposure to Perfluorobutanesulfonate. Environ Sci Technol. 2018;52:4432-9.
Kim DH, Kim UJ, Kim HY, Choi SD, Oh JE. Perfluoroalkyl substances in serum from South Korean infants with congenital hypothyroidism and healthy infants--Its relationship with thyroid hormones. Environ Res. 2016;147:399-404.
Nian M, Li QQ, Bloom M, Qian ZM, Syberg KM, Vaughn MG, et al. Liver function biomarkers disorder is associated with exposure to perfluoroalkyl acids in adults: Isomers of C8 Health Project in China. Environ Res. 2019;172:81-8.
Conley JM, Lambright CS, Evans N, Strynar MJ, McCord J, McIntyre BS, et al. Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats. Environ Health Perspect. 2019;127:37008.
Ernst A, Brix N, Lauridsen LLB, Olsen J, Parner ET, Liew Z, et al. Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort. Environ Health Perspect. 2019;127:17004.
Di Nisio A, De Rocco Ponce M, Giadone A, Rocca MS, Guidolin D, Foresta C. Perfluoroalkyl substances and bone health in young men: a pilot study. Endocrine. 2020;67:678-84.
Li N, Liu Y, Papandonatos GD, Calafat AM, Eaton CB, Kelsey KT, et al. Gestational and childhood exposure to per- and polyfluoroalkyl substances and cardiometabolic risk at age 12 years. Environ Int. 2021;147:106344.
Houck KA, Patlewicz G, Richard AM, Williams AJ, Shobair MA, Smeltz M, et al. Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure. Toxicology. 2021;457:152789.
Weiss JM, Andersson PL, Lamoree MH, Leonards PE, van Leeuwen SP, Hamers T. Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin. Toxicol Sci. 2009;109:206-16.
Wen LL, Lin CY, Chou HC, Chang CC, Lo HY, Juan SH. Perfluorooctanesulfonate Mediates Renal Tubular Cell Apoptosis through PPARgamma Inactivation. PLoS One. 2016;11:e0155190.
Almeida NMS, Eken Y, Wilson AK. Binding of Per- and Polyfluoro-alkyl Substances to Peroxisome Proliferator-Activated Receptor Gamma. ACS Omega. 2021;6:15103-14.
Kjeldsen LS, Bonefeld-Jorgensen EC. Perfluorinated compounds affect the function of sex hormone receptors. Environ Sci Pollut Res Int. 2013;20:8031-44.
Zhang YM, Dong XY, Fan LJ, Zhang ZL, Wang Q, Jiang N, et al. Poly- and perfluorinated compounds activate human pregnane X receptor. Toxicology. 2017;380:23-9.
Di Nisio A, Rocca MS, De Toni L, Sabovic I, Guidolin D, Dall'Acqua S, et al. Endocrine disruption of vitamin D activity by perfluoro-octanoic acid (PFOA). Sci Rep. 2020;10:16789.
Ren XM, Qin WP, Cao LY, Zhang J, Yang Y, Wan B, et al. Binding interactions of perfluoroalkyl substances with thyroid hormone transport proteins and potential toxicological implications. Toxicology. 2016;366-367:32-42.
Bach CC, Vested A, Jorgensen KT, Bonde JP, Henriksen TB, Toft G. Perfluoroalkyl and polyfluoroalkyl substances and measures of human fertility: a systematic review. Crit Rev Toxicol. 2016;46:735-55.
Di Nisio A, Sabovic I, Valente U, Tescari S, Rocca MS, Guidolin D, et al. Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence. J Clin Endocrinol Metab. 2019;104:1259-71.
Shi Z, Ding L, Zhang H, Feng Y, Xu M, Dai J. Chronic exposure to perfluorododecanoic acid disrupts testicular steroidogenesis and the expression of related genes in male rats. Toxicol Lett. 2009;188:192-200.
Lopez-Doval S, Salgado R, Pereiro N, Moyano R, Lafuente A. Perfluorooctane sulfonate effects on the reproductive axis in adult male rats. Environ Res. 2014;134:158-68.
Lopez-Doval S, Salgado R, Lafuente A. The expression of several reproductive hormone receptors can be modified by perfluorooctane sulfonate (PFOS) in adult male rats. Chemosphere. 2016;155:488-97.
Kang JS, Choi JS, Park JW. Transcriptional changes in steroidogenesis by perfluoroalkyl acids (PFOA and PFOS) regulate the synthesis of sex hormones in H295R cells. Chemosphere. 2016;155:436-43.
Chaparro-Ortega A, Betancourt M, Rosas P, Vazquez-Cuevas FG, Chavira R, Bonilla E, et al. Endocrine disruptor effect of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on porcine ovarian cell steroidogenesis. Toxicol In Vitro. 2018;46:86-93.
Toft G, Jonsson BA, Lindh CH, Giwercman A, Spano M, Heederik D, et al. Exposure to perfluorinated compounds and human semen quality in Arctic and European populations. Hum Reprod. 2012;27:2532-40.
Louis GM, Chen Z, Schisterman EF, Kim S, Sweeney AM, Sundaram R, et al. Perfluorochemicals and human semen quality: the LIFE study. Environ Health Perspect. 2015;123:57-63.
Barrett ES, Chen C, Thurston SW, Haug LS, Sabaredzovic A, Fjeldheim FN, et al. Perfluoroalkyl substances and ovarian hormone concentrations in naturally cycling women. Fertil Steril. 2015;103:1261-70.
Tsai MS, Lin CY, Lin CC, Chen MH, Hsu SH, Chien KL, et al. Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults. Int J Hyg Environ Health. 2015;218:437-43.
Velez MP, Arbuckle TE, Fraser WD. Maternal exposure to perfluorinated chemicals and reduced fecundity: the MIREC study. Hum Reprod. 2015;30:701-9.
Fei C, McLaughlin JK, Lipworth L, Olsen J. Maternal levels of perfluorinated chemicals and subfecundity. Hum Reprod. 2009;24:1200-5.
Ding J, Zhou H, Liu Y, Cai J, Longnecker MP. Estimating effect of environmental contaminants on women's subfecundity for the MoBa study data with an outcome-dependent sampling scheme. Biostatistics. 2014;15:636-50.
Jin ML. [Combined UFTM for 140 patients with advanced gastric cancer]. Zhonghua Zhong Liu Za Zhi. 1989;11:130-2.
Wikstrom S, Hussein G, Lingroth Karlsson A, Lindh CH, Bornehag CG. Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage. Sci Rep. 2021;11:3568.
Wang B, Zhang R, Jin F, Lou H, Mao Y, Zhu W, et al. Perfluoroalkyl substances and endometriosis-related infertility in Chinese women. Environ Int. 2017;102:207-12.
Zhang S, Tan R, Pan R, Xiong J, Tian Y, Wu J, et al. Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Premature Ovarian Insufficiency in Chinese Women. J Clin Endocrinol Metab. 2018;103:2543-51.
Di Nisio A, Rocca MS, Sabovic I, De Rocco Ponce M, Corsini C, Guidolin D, et al. Perfluorooctanoic acid alters progesterone activity in human endometrial cells and induces reproductive alterations in young women. Chemosphere. 2020;242:125208.
Erinc A, Davis MB, Padmanabhan V, Langen E, Goodrich JM. Considering environmental exposures to per- and polyfluoroalkyl substances (PFAS) as risk factors for hypertensive disorders of pregnancy. Environ Res. 2021;197:111113.
Yahia D, El-Nasser MA, Abedel-Latif M, Tsukuba C, Yoshida M, Sato I, et al. Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction. J Toxicol Sci. 2010;35:527-33.
Song P, Li D, Wang X, Zhong X. Effects of perfluorooctanoic acid exposure during pregnancy on the reproduction and development of male offspring mice. 2018;50:e13059.
Das KP, Grey BE, Rosen MB, Wood CR, Tatum-Gibbs KR, Zehr RD, et al. Developmental toxicity of perfluorononanoic acid in mice. Reprod Toxicol. 2015;51:133-44.
Kashino I, Sasaki S, Okada E, Matsuura H, Goudarzi H, Miyashita C, et al. Prenatal exposure to 11 perfluoroalkyl substances and fetal growth: A large-scale, prospective birth cohort study. Environ Int. 2020;136:105355.
Li M, Zeng XW, Qian ZM, Vaughn MG, Sauve S, Paul G, et al. Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study. Environ Int. 2017;102:1-8.
Wang H, Du H, Yang J, Jiang H, O K, Xu L, et al. PFOS, PFOA, estrogen homeostasis, and birth size in Chinese infants. Chemosphere. 2019;221:349-55.
Yao Q, Gao Y, Zhang Y, Qin K, Liew Z, Tian Y. Associations of paternal and maternal per- and polyfluoroalkyl substances exposure with cord serum reproductive hormones, placental steroidogenic enzyme and birth weight. Chemosphere. 2021;285:131521.
Pearce JL, Neelon B, Bloom MS, Buckley JP, Ananth CV, Perera F, et al. Exploring associations between prenatal exposure to multiple endocrine disruptors and birth weight with exposure continuum mapping. Environ Res. 2021;200:111386.
Gundacker C, Graf-Rohrmeister K, Gencik M, Hengstschlager M, Holoman K, Rosa P, et al. Gene Variants Determine Placental Transfer of Perfluoroalkyl Substances (PFAS), Mercury (Hg) and Lead (Pb), and Birth Outcome: Findings From the UmMuKi Bratislava-Vienna Study. Front Genet. 2021;12:664946.
Kung YP, Lin CC, Chen MH, Tsai MS, Hsieh WS, Chen PC. Intrauterine exposure to per- and polyfluoroalkyl substances may harm children's lung function development. Environ Res. 2021;192:110178.
Chen MH, Ha EH, Liao HF, Jeng SF, Su YN, Wen TW, et al. Perfluorinated compound levels in cord blood and neurodevelopment at 2 years of age. Epidemiology. 2013;24:800-8.
Wang Y, Rogan WJ, Chen HY, Chen PC, Su PH, Chen HY, et al. Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study. Int J Hyg Environ Health. 2015;218:639-44.
Vuong AM, Yolton K, Webster GM, Sjodin A, Calafat AM, Braun JM, et al. Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children. Environ Res. 2016;147:556-64.
Oulhote Y, Steuerwald U, Debes F, Weihe P, Grandjean P. Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances. Environ Int. 2016;97:237-45.
Niu J, Liang H, Tian Y, Yuan W, Xiao H, Hu H, et al. Prenatal plasma concentrations of Perfluoroalkyl and polyfluoroalkyl substances and neuropsychological development in children at four years of age. Environ Health. 2019;18:53.
Oh J, Bennett DH, Calafat AM, Tancredi D, Roa DL, Schmidt RJ, et al. Prenatal exposure to per- and polyfluoroalkyl substances in association with autism spectrum disorder in the MARBLES study. Environ Int. 2021;147:106328.
Hines EP, White SS, Stanko JP, Gibbs-Flournoy EA, Lau C, Fenton SE. Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life. Mol Cell Endocrinol. 2009;304:97-105.
Lv Z, Li G, Li Y, Ying C, Chen J, Chen T, et al. Glucose and lipid homeostasis in adult rat is impaired by early-life exposure to perfluorooctane sulfonate. Environ Toxicol. 2013;28:532-42.
Wang L, Wang Y, Liang Y, Li J, Liu Y, Zhang J, et al. PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion. Sci Rep. 2014;4:4582.
Lu Y, Pan Y, Sheng N, Zhao AZ, Dai J. Perfluorooctanoic acid exposure alters polyunsaturated fatty acid composition, induces oxidative stress and activates the AKT/AMPK pathway in mouse epididymis. Chemosphere. 2016;158:143-53.
Watkins AM, Wood CR, Lin MT, Abbott BD. The effects of perfluorinated chemicals on adipocyte differentiation in vitro. Mol Cell Endocrinol. 2015;400:90-101.
Xu J, Shimpi P, Armstrong L, Salter D, Slitt AL. PFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathway. Toxicol Appl Pharmacol. 2016;290:21-30.
Andersen CS, Fei C, Gamborg M, Nohr EA, Sorensen TI, Olsen J. Prenatal exposures to perfluorinated chemicals and anthropometry at 7 years of age. Am J Epidemiol. 2013;178:921-7.
Martinsson M, Nielsen C, Bjork J, Rylander L, Malmqvist E, Lindh C, et al. Intrauterine exposure to perfluorinated compounds and overweight at age 4: A case-control study. PLoS One. 2020;15:e0230137.
Lauritzen HB, Larose TL, Oien T, Sandanger TM, Odland JO, van de Bor M, et al. Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study. Environ Health. 2018;17:9.
Hartman TJ, Calafat AM, Holmes AK, Marcus M, Northstone K, Flanders WD, et al. Prenatal Exposure to Perfluoroalkyl Substances and Body Fatness in Girls. Child Obes. 2017;13:222-30.
Jansen A, Muller MHB, Gronnestad R, Klungsoyr O, Polder A, Skjerve E, et al. Decreased plasma levels of perfluoroalkylated substances one year after bariatric surgery. Sci Total Environ. 2019;657:863-70.
Halldorsson TI, Rytter D, Haug LS, Bech BH, Danielsen I, Becher G, et al. Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study. Environ Health Perspect. 2012;120:668-73.
Braun JM, Chen A, Romano ME, Calafat AM, Webster GM, Yolton K, et al. Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study. Obesity (Silver Spring). 2016;24:231-7.
Mora AM, Oken E, Rifas-Shiman SL, Webster TF, Gillman MW, Calafat AM, et al. Prenatal Exposure to Perfluoroalkyl Substances and Adiposity in Early and Mid-Childhood. Environ Health Perspect. 2017;125:467-73.
Karlsen M, Grandjean P, Weihe P, Steuerwald U, Oulhote Y, Valvi D. Early-life exposures to persistent organic pollutants in relation to overweight in preschool children. Reprod Toxicol. 2017;68:145-53.
Tian YP, Zeng XW, Bloom MS, Lin S, Wang SQ, Yim SHL, et al. Isomers of perfluoroalkyl substances and overweight status among Chinese by sex status: Isomers of C8 Health Project in China. Environ Int. 2019;124:130-8.
Geiger SD, Yao P, Vaughn MG, Qian Z. PFAS exposure and overweight/obesity among children in a nationally representative sample. Chemosphere. 2021;268:128852.
Averina M, Brox J, Huber S, Furberg AS. Exposure to perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in adolescents. The Fit Futures study. Environ Res. 2021;195:110740.
Coperchini F, Croce L, Ricci G, Magri F, Rotondi M, Imbriani M, et al. () Thyroid Disrupting Effects of Old and New Generation PFAS. Front Endocrinol (Lausanne). 2020;11:612320.
Brent GA. Mechanisms of thyroid hormone action. J Clin Invest. 2012;122:3035-43.
Wang J, Hallinger DR, Murr AS, Buckalew AR, Lougee RR, Richard AM, et al. High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition. Environ Int. 2019;126:377-86.
Conti A, Strazzeri C, Rhoden KJ. Perfluorooctane sulfonic acid, a persistent organic pollutant, inhibits iodide accumulation by thyroid follicular cells in vitro. Mol Cell Endocrinol. 2020;515:110922.
Song M, Kim YJ, Park YK, Ryu JC. Changes in thyroid peroxidase activity in response to various chemicals. J Environ Monit. 2012;14:2121-6.
Itoh S, Araki A, Miyashita C, Yamazaki K, Goudarzi H, Minatoya M, et al. Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study. Environ Int. 2019;133:105139.
Webster GM, Venners SA, Mattman A, Martin JW. Associations between perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: a population-based cohort study. Environ Res. 2014;133:338-47.
Guo J, Zhang J, Wang Z, Zhang L, Qi X, Zhang Y, et al. Umbilical cord serum perfluoroalkyl substance mixtures in relation to thyroid function of newborns: Findings from Sheyang Mini Birth Cohort Study. Chemosphere. 2021;273:129664.
Preston EV, Webster TF, Oken E, Claus Henn B, McClean MD, Rifas-Shiman SL, et al. Maternal Plasma per- and Polyfluoroalkyl Substance Concentrations in Early Pregnancy and Maternal and Neonatal Thyroid Function in a Prospective Birth Cohort: Project Viva (USA). Environ Health Perspect. 2018;126:027013.
Preston EV, Webster TF, Claus Henn B, McClean MD, Gennings C, Oken E, et al. Prenatal exposure to per- and polyfluoroalkyl substances and maternal and neonatal thyroid function in the Project Viva Cohort: A mixtures approach. Environ Int. 2020;139:105728.
Caron-Beaudoin E, Ayotte P, Laouan Sidi EA, et al. Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec. Environ Int. 2019;128:13-23.
Lopez-Espinosa MJ, Mondal D, Armstrong B, Bloom MS, Fletcher T. Thyroid function and perfluoroalkyl acids in children living near a chemical plant. Environ Health Perspect. 2012;120:1036-41.
Lin CY, Wen LL, Lin LY, Wen TW, Lien GW, Hsu SH, et al. The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults. J Hazard Mater. 2013;244-245:637-44.
Blake BE, Pinney SM, Hines EP, Fenton SE, Ferguson KK. Associations between longitudinal serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald Community Cohort. Environ Pollut. 2018;242:894-904.
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