Nivoi kadmijuma u humanom tkivu dojke i nivoi estradiola u serumu: Postoji li veza?

  • Aleksandra Buha Djordjevic Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju „Akademik Danilo Soldatović”
  • Milena Andjelković Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Elena Kačavenda Univerzitet u Beogradu– Farmaceutski fakultet, Centar za naučnoistraživački rad studenata
  • Dragana Javorac Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju „Akademik Danilo Soldatović”
  • Evica Antonijević Miljaković Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju „Akademik Danilo Soldatović”
  • Djurdjica Marić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju „Akademik Danilo Soldatović”
  • Katarina Baralić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju „Akademik Danilo Soldatović”
  • Danijela Djukić-Ćosić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju „Akademik Danilo Soldatović”
  • Marijana Ćurčić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju „Akademik Danilo Soldatović”
  • Biljana Antonijević Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju „Akademik Danilo Soldatović”
  • Zorica Bulat Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju „Akademik Danilo Soldatović”
DOI: https://doi.org/10.5937/arhfarm71-34280
Ključne reči: Endokrini ometači, kadmijum, BMD koncept, PROAST softver, humane studije

Sažetak


Kadmijum (Cd), jedan od najzastupljenijih zagađivača životne sredine, dokazan je endokrini ometač. Međutim, podaci o postojanju odnosa između doze Cd i odgovora-nivoa hormona nisu dovoljno istraženi, posebno podaci sakupljeni iz studija na ljudima. Stoga je cilj ove studije bio da se utvrdi mogućnost analize podataka dobijenih iz studije slučaja-kontrole kod pacijentkinja sa benignim/malignim tumorom dojke, primenom koncepta Benčmark doze (BMD). Prikupljeni podaci o nivoima Cd u tkivu dojke i serumskim nivoima estrogena obrađeni su u PROAST softveru uz korišćenje različitih varijabli. Ispitivan je odnos doza-odgovor između unutrašnje doze Cd (koncentracije u tkivu dojke) i estradiola u serumu i izračunati BMD intervali. Utvrđeno je postojanje odnosa između koncentracije Cd u tkivu dojke i nivoa estradiola u serumu koje ukazuje na niže nivoe estradiola u serumu kao posledica veće koncentracije Cd u tkivu dojke. Kao jedno od retkih istraživanja ovog tipa, dobijeni rezultati mogli bi predstavljati početak otkrivanja mogućnosti analize podataka prikupljenih u studijama na ljudima primenom BMD pristupa.

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Objavljeno
2021/12/27
Broj časopisa
Vol. 71 Br. Notebook 6 (2021): Arhiv za farmaciju
Rubrika
Originalni naučni rad
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