Molecular biomarkers in multiple sclerosis

Danica Michaličková; Hatice Kübra  Öztürk; Debanjan Das; Syed Osama  Bukhari; Ondřej  Slanař

doi:10.5937/arhfarm72-36165

Danica Michaličková Charles University - Institute of Pharmacology, First Faculty of Medicine
Hatice Kübra Öztürk Charles University - Institute of Pharmacology, First Faculty of Medicine
Debanjan Das Charles University - Institute of Pharmacology, First Faculty of Medicine
Syed Osama Bukhari Charles University - Institute of Pharmacology, First Faculty of Medicine
Ondřej Slanař Charles University - Institute of Pharmacology, First Faculty of Medicine

DOI: https://doi.org/10.5937/arhfarm72-36165

Ključne reči: multipla skleroza, molekularni biomarker, neurofilament, cerebrospinalna tečnost, dijagnoza, terapijski odgovor

Sažetak

Multipla skleroza (MS) je veoma heterogena bolest u pogledu radioloških, patoloških i kliničkih karakteristika i terapijskog odgovora, uključujući i efikasnost i bezbednosni profil tretmana. Shodno tome, postoji velika potražnja za biomarkerima koji osetljivo i specifično reflektuju specifične aspekte heterogenosti MS, i koji mogu pomoći u boljem razumevanju dijagnoze bolesti, prognoze, predviđanja odgovora na lečenje, kao i u razvoju novih tretmana. Trenutno, kliničke karakteristike (npr. stopa relapsa i progresija bolesti) i snimanje magnetnom rezonancom igraju najvažniju ulogu u kliničkoj klasifikaciji i proceni toka MS. Molekularni biomarkeri (npr. oligoklonalne imunoglobulin G (IgG) trake, IgG indeks, anti-akvaporin-4 antitela, anti-interferon-beta i anti-natalizumab neutrališuća antitela, anti-varicella zoster virus i anti-John Cunningham (JC) antitela) odlično dopunjuju ove markere. U ovom preglednom radu je dat kratak rezime validiranih, klinički korisnih molekularnih biomarkera, kao i biomarkera u fazi istraživanja u MS koji se mogu koristiti za predikciju, dijagnozu, određivanje aktivnosti bolesti i terapijskog odgovora u pogledu efikasnosti i bezbednosti lečenja.

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Molekularni biomarkeri u multiploj sklerozi

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Reference