Ukupan broj leukocita, diferencijalna krvna slika i njihovi indeksi u diabetes mellitus-u tip 2-Revijalni članak

  • Aleksandra Klisić Univerzitet Crne Gore - Medicinski fakultet, Dom zdravlja Podgorica
  • Jelena Kotur-Stevuljević Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za medicinsku biohemiju
  • Ana Ninić Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za medicinsku biohemiju
DOI: https://doi.org/10.5937/arhfarm72-36386
Ključne reči: dijabetes, leukociti, gojaznost, neutrofili, inflamacija

Sažetak


Zbog povećane prevalence komplikacija povezanih sa gojaznošću, naročito diabetes mellitus-a tip (DM2), posebna pažnja se posvećuje različitim adipokinima i citokinima, tj. biomarkerima koje luči uvećano visceralno masno tkivo. Pomenuti medijatori inflamacije smanjuju insulinsku senzitivnost vršeći uticaj na signalne puteve insulina. Ukoliko ovi procesi potraju duže dolazi do pojave insulinske rezistencije i DM2, sa tipičnim nalazom hronične inflamacije niskog stepena. Ovaj revijalni članak akcenat stavlja na određene hematološke parametre koji odražavaju stepen inflamacije, kao što je broj leukocita, njihove podvrste, kao i indeksi izvedeni iz istih. Ovi parametri su lako merljivi, ekonomski isplativi i široko dostupni u ambulantama primarne zdravstvene zaštite.Bolje poznavanje promena navedenih hematoloških parametara u DM2, pored biomarkera glikoregulacije, može omogućiti lekarima pravovremenu reakciju kada se radi o pacijentima sa ovim metaboličkim poremećajem.

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Objavljeno
2022/04/28
Broj časopisa
Vol. 72 Br. Notebook 2 (2022): Arhiv za farmaciju
Rubrika
Pregledni (Revijalni) rad
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